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Rhot2 Gene Detail
Summary
  • Symbol
    Rhot2
  • Name
    ras homolog family member T2
  • Synonyms
    Arht2, Miro2
  • Feature Type
    protein coding gene
  • IDs
    MGI:2384892
    NCBI Gene: 214952
  • Alliance
    genome feature page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr17:26057431-26063499 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 17, 12.93 cM, cytoband A3.3
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    167 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2384892
 protein coding gene Chr17:26057431-26063825 (-)
129S1/SvImJ ENSMUSG00200049737
 protein coding gene Chr17:21502424-21508812 (-)
A/J ENSMUSG00195048217
 protein coding gene Chr17:22519617-22526011 (-)
AKR/J ENSMUSG00220053218
 protein coding gene Chr17:21566374-21572768 (-)
BALB/cJ ENSMUSG00180047277
 protein coding gene Chr17:21800430-21806818 (-)
C3H/HeJ ENSMUSG00175053664
 protein coding gene Chr17:21558674-21565064 (-)
C57BL/6NJ ENSMUSG00215053033
 protein coding gene Chr17:21567016-21573410 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0021258
 protein coding gene Chr17:21672889-21679573 (-)
CAST/EiJ ENSTCUG00005047035
 protein coding gene Chr17:22148517-22154894 (-)
CBA/J ENSMUSG00210049286
 protein coding gene Chr17:21397515-21403905 (-)
DBA/2J ENSMUSG00185040685
 protein coding gene Chr17:23607881-23614275 (-)
FVB/NJ ENSMUSG00205037159
 protein coding gene Chr17:21863336-21869734 (-)
JF1/MsJ ENSUMUG00000055619
 protein coding gene Chr17:23063190-23069581 (-)
LP/J ENSMUSG00230054501
 protein coding gene Chr17:25006959-25013347 (-)
NOD/ShiLtJ ENSMUSG00190054080
 protein coding gene Chr17:21496596-21502990 (-)
NZO/HlLtJ ENSMUSG00225052818
 protein coding gene Chr17:26926946-26933340 (-)
PWK/PhJ ENSLUMG00010039098
 protein coding gene Chr17:20982325-20988744 (-)
SPRET/EiJ ENSMSPG00010047165
 protein coding gene Chr17:22300338-22307570 (-)
WSB/EiJ ENSIUOG00005046621
 protein coding gene Chr17:22240261-22246642 (-)



Homology
more
  • Human Ortholog
    RHOT2, ras homolog family member T2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    RHOT2, ras homolog family member T2
  • Synonyms
    ARHT2, C16orf39, MIRO-2, MIRO2, RASL
  • Links
    NCBI Gene ID: 89941
    UniProt: Q8IXI1

  • Chr Location
    16p13.3; chr16:668083-674174 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    5 phenotypes from 1 allele in 2 genetic backgrounds
    12 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele are viable and fertile with normal mitochondria distribution in neurons.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    41
  • GO References
    10
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    732
  • Tissues
    20
  • cDNA Data
    7
  • Literature Summary
    4
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 214952 NCBI Gene Model | MGI Sequence Detail 6069 C57BL/6J ±  kb
    transcript NM_001364950 RefSeq | MGI Sequence Detail 2838 C57BL/6  
    polypeptide Q8JZN7 UniProt | EBI | MGI Sequence Detail 620 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 9
      cDNA 8
      Primer pair 1
      Antibodies 3

      Microarray probesets 3
    References
    more
    • Summaries
      All 47
      Developmental Gene Expression 4
      Gene Ontology 10
      Phenotypes 12
    • Earliest
      J:86784 Bergstrom DE, et al., Overlapping deletions spanning the proximal two-thirds of the mouse t complex. Mamm Genome. 2003 Dec;14(12):817-29
    • Latest
      J:386400 Froese N, et al., RHOT Proteins Link Mitochondrial Motility to Cardiomyocyte Sarcomere Maturation. Circ Res. 2026 Apr 24;138(9):e327297
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory