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Cmtr2 Gene Detail
Summary
  • Symbol
    Cmtr2
  • Name
    cap methyltransferase 2
  • Synonyms
    C730036L12Rik, Ftsjd1, MGC:38131
  • Feature Type
    protein coding gene
  • IDs
    MGI:2384580
    NCBI Gene: 234728
  • Alliance
    genome feature page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr8:110942297-110951118 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 8, 57.48 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    347 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2384580
 protein coding gene Chr8:110941977-110951121 (+)
129S1/SvImJ ENSMUSG00200013178
 protein coding gene Chr8:105245843-105254664 (+)
A/J ENSMUSG00195017163
 protein coding gene Chr8:105558412-105567233 (+)
AKR/J ENSMUSG00220014482
 protein coding gene Chr8:105700808-105709629 (+)
BALB/cJ ENSMUSG00180017500
 protein coding gene Chr8:105564133-105572955 (+)
C3H/HeJ ENSMUSG00175023455
 protein coding gene Chr8:105620762-105629583 (+)
C57BL/6NJ ENSMUSG00215026047
 protein coding gene Chr8:105223771-105232592 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0031558
 protein coding gene Chr8:101306565-101315697 (+)
CAST/EiJ ENSTCUG00005032304
 protein coding gene Chr8:104968902-104977777 (+)
CBA/J ENSMUSG00210028115
 protein coding gene Chr8:105547970-105556791 (+)
DBA/2J ENSMUSG00185016389
 protein coding gene Chr8:111657034-111665855 (+)
FVB/NJ ENSMUSG00205020609
 protein coding gene Chr8:104560358-104569179 (+)
JF1/MsJ ENSUMUG00000010077
 protein coding gene Chr8:113990340-113999160 (+)
LP/J ENSMUSG00230035669
 protein coding gene Chr8:115336903-115345724 (+)
NOD/ShiLtJ ENSMUSG00190022553
 protein coding gene Chr8:105698996-105707817 (+)
NZO/HlLtJ ENSMUSG00225017578
 protein coding gene Chr8:118687589-118696410 (+)
PWK/PhJ ENSLUMG00010026648
 protein coding gene Chr8:105435249-105441731 (+)
SPRET/EiJ no annotation
WSB/EiJ ENSIUOG00005027915
 protein coding gene Chr8:106347133-106355954 (+)



Homology
more
  • Human Ortholog
    CMTR2, cap methyltransferase 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CMTR2, cap methyltransferase 2
  • Synonyms
    AFT, FTSJD1, HMTr2, MTr2
  • Links
    NCBI Gene ID: 55783
    UniProt: Q8IYT2

  • Chr Location
    16q22.2; chr16:71281389-71289722 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    21 phenotypes from 2 alleles in 4 genetic backgrounds
    12 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    24
  • GO References
    9
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    651
  • Tissues
    44
  • cDNA Data
    9
  • Literature Summary
    2
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000046441 Ensembl Gene Model | MGI Sequence Detail 8822 C57BL/6J ±  kb
    transcript ENSMUST00000056972 Ensembl | MGI Sequence Detail 3545 Not Applicable  
    polypeptide ENSMUSP00000060558 Ensembl | MGI Sequence Detail 767 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      2 Sequences
    • Protein Ontology
      PR:000030551 cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 2
      (term hierarchy)
    • EC
      2.1.1.296
    • InterPro Domains
      IPR025807 Adrift-type ribose 2-O-methyltransferase domain
      IPR050851 mRNA Cap 2'-O-Ribose Methyltransferase
      IPR002877 Ribosomal RNA methyltransferase, FtsJ domain
      IPR029063 S-adenosyl-L-methionine-dependent methyltransferase superfamily
    Molecular
    Reagents
    less
    • All nucleic 10
      cDNA 9
      Primer pair 1

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGI:2142707, MGI:2443150
    References
    more
    • Summaries
      All 43
      Developmental Gene Expression 2
      Gene Ontology 9
      Phenotypes 12
    • Earliest
      J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
    • Latest
      J:389086 Zheng B, et al., Cap 2'-O-methyltransferase CMTR2 regulates male meiosis independent of its methyltransferase activity. Nucleic Acids Res. 2026 Jul 3;54(13)
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory