Serpina3f MGI Mouse Gene Detail - MGI:2182838 - serine (or cysteine) peptidase inhibitor, clade A, member 3F

Symbol

Serpina3f
Name

serine (or cysteine) peptidase inhibitor, clade A, member 3F
Synonyms

2A1, alpha-1 antiproteinasin, antitrypsin

Feature Type

protein coding gene
IDs

MGI:2182838
NCBI Gene: 238393
Alliance

gene page
Transcription Start Sites

2 TSS

Sequence Map

Chr12:104180803-104187388 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 12, 53.65 cM, cytoband F1
Mapping Data

2 experiments

SNPs within 2kb

188 from dbSNP Build 142
Strain Annotations

13

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2182838	protein coding gene	Chr12:104180803-104187388 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0020070	protein coding gene	Chr12:105973293-105981894 (+)
A/J	MGP_AJ_G0020024	protein coding gene	Chr12:101975910-101981904 (+)
AKR/J	MGP_AKRJ_G0020001	protein coding gene	Chr12:104844692-104886196 (+)
BALB/cJ	MGP_BALBcJ_G0020012	protein coding gene	Chr12:102355888-102377843 (+)
C3H/HeJ	no annotation
C57BL/6NJ	no annotation
CAROLI/EiJ	no annotation
CAST/EiJ	MGP_CASTEiJ_G0019355	protein coding gene	Chr12:100148593-100154552 (+)
CBA/J	no annotation
DBA/2J	MGP_DBA2J_G0019898	protein coding gene	Chr12:101487622-101539923 (+)
FVB/NJ	no annotation
LP/J	MGP_LPJ_G0019973	protein coding gene	Chr12:105838944-105856386 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0019922	protein coding gene	Chr12:116972318-116990202 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0020485	protein coding gene	Chr12:104329536-104348299 (+)
PWK/PhJ	MGP_PWKPhJ_G0019117	protein coding gene	Chr12:95964127-95978285 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0018920	protein coding gene	Chr12:98585357-98620646 (+)
WSB/EiJ	MGP_WSBEiJ_G0019414	protein coding gene	Chr12:105256193-105317524 (+)

Human Ortholog

SERPINA3, serpin family A member 3

Vertebrate Orthologs

7

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

SERPINA3, serpin family A member 3
Synonyms

AACT, ACT, GIG24, GIG25
Links

HGNC:16

NCBI Gene ID: 12

neXtProt AC: NX_P01011

UniProt: P01011
Chr Location

14q32.13; chr14:94612384-94624055 (+) GRCh38

MGI Vertebrate Homology

Serpina3f stringent orthology
1 human;1 mouse;1 rat;5 zebrafish
HCOP

vertebrate homology predictions: SERPINA3
Gene Tree

Serpina3f

Diseases

3 with human SERPINA3 associations

				Human Disease	Mouse Models
				chronic obstructive pulmonary disease IDs chronic obstructive pulmonary disease DOID:3083 DOID:11500 DOID:6144 EFO:0000341 ICD10CM:J44.9 MESH:D029424 NCI:C3199 OMIM:606963 UMLS_CUI:C0024117
				cystic fibrosis IDs cystic fibrosis DOID:1485 DOID:12447 DOID:13383 DOID:14395 DOID:1484 ICD10CM:E84 ICD9CM:277.0 MESH:D003550 NCI:C2975 OMIM:219700 ORDO:586 UMLS_CUI:C0010674
				vasculitis IDs vasculitis DOID:865 MESH:D014657 NCI:C26912 UMLS_CUI:C0042384

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

2 phenotype references

All Mutations and Alleles

1
Chemically induced (other)

1
Genomic Mutations

1 involving Serpina3f
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

28 strains or lines available

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All GO Annotations

7
GO References

4

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

706
cDNA Data

6
Literature Summary

1

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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All Sequences

38
RefSeq

6
UniProt

4
CCDS

CCDS26149.1

Ensembl

ENSMUSG00000066363 (Evidence)
NCBI Gene

238393

			Length	Strain/Species	Flank
genomic	238393	NCBI Gene Model \| MGI Sequence Detail	6586	C57BL/6J	± kb
transcript	NM_001168294	RefSeq \| MGI Sequence Detail	2254	C57BL/6
polypeptide	Q80X76	UniProt \| EBI \| MGI Sequence Detail	445	Not Applicable

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UniProt

4 Sequences
Protein Ontology

PR:000015936 serine protease inhibitor A3F

(term hierarchy)
InterPro Domains

IPR023795 Serpin, conserved site

IPR023796 Serpin domain

IPR000215 Serpin family

IPR036186 Serpin superfamily

IPR042178 Serpin superfamily, domain 1

IPR042185 Serpin superfamily, domain 2

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All nucleic 8

Genomic 2

cDNA 6

Microarray probesets 1

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MGI:2681849

Summaries

All 25

Developmental Gene Expression 1

Gene Ontology 4

Phenotypes 2
Earliest

J:25107 Inglis JD, et al., The murine Spi-2 proteinase inhibitor locus: a multigene family with a hypervariable reactive site domain. EMBO J. 1991 Feb;10(2):255-61
Latest

J:239279 Kidoya H, et al., APJ Regulates Parallel Alignment of Arteries and Veins in the Skin. Dev Cell. 2015 May 04;33(3):247-59

TSS for Serpina3f:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr114833	Chr12:104180771-104180791 (+)	-22 bp
Tssr114834	Chr12:104180797-104180808 (+)	0 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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