About   Help   FAQ
Oas1e Gene Detail
Summary
  • Symbol
    Oas1e
  • Name
    2'-5' oligoadenylate synthetase 1E
  • Synonyms
    2'-5' oligoadenylate synthetase-like 7
Location &
Maps
more
  • Sequence Map
    Chr5:120924377-120933595 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 5, 60.64 cM, cytoband F
  • Mapping Data
    5 experiments
Strain
Comparison
more
  • SNPs within 2kb
    290 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2180856
 protein coding gene Chr5:120924291-120933595 (-)
129S1/SvImJ ENSMUSG00200023206
 protein coding gene Chr5:114663538-114672839 (-)
A/J ENSMUSG00195010885
 protein coding gene Chr5:114184724-114194025 (-)
AKR/J ENSMUSG00220044745
 protein coding gene Chr5:113685676-113694979 (-)
BALB/cJ ENSMUSG00180030403
 protein coding gene Chr5:114299320-114308622 (-)
C3H/HeJ ENSMUSG00175027915
 protein coding gene Chr5:116297373-116306677 (-)
C57BL/6NJ ENSMUSG00215043042
 protein coding gene Chr5:114331223-114340527 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0027675
 protein coding gene Chr5:113867945-113890421 (+)
CAST/EiJ ENSTCUG00005040165
 protein coding gene Chr5:113503437-113512731 (-)
CBA/J ENSMUSG00210007307
 protein coding gene Chr5:115048245-115057549 (-)
DBA/2J ENSMUSG00185053236
 protein coding gene Chr5:118107565-118116869 (-)
FVB/NJ ENSMUSG00205042261
 protein coding gene Chr5:113961367-113970675 (-)
JF1/MsJ ENSUMUG00000048971
 protein coding gene Chr5:120943705-120953004 (-)
LP/J ENSMUSG00230038993
 protein coding gene Chr5:122185736-122195037 (-)
NOD/ShiLtJ ENSMUSG00190024728
 protein coding gene Chr5:113995452-114004753 (-)
NZO/HlLtJ ENSMUSG00225014078
 protein coding gene Chr5:129862851-129872155 (-)
PWK/PhJ ENSLUMG00010030081
 protein coding gene Chr5:112846434-112855781 (-)
SPRET/EiJ ENSMSPG00010034138
 protein coding gene Chr5:116168589-116177684 (-)
WSB/EiJ ENSIUOG00005015467
 protein coding gene Chr5:116684159-116693458 (-)



Homology
more
  • Human Ortholog
    OAS1, 2'-5'-oligoadenylate synthetase 1
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    OAS1, 2'-5'-oligoadenylate synthetase 1
  • Synonyms
    E18/E16, IFI-4, IMD100, OIAS, OIASI
  • Links
    NCBI Gene ID: 4938
    UniProt: P00973

  • Chr Location
    12q24.13; chr12:112905856-112933219 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with human OAS1 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    9 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    44
  • GO References
    5
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    615
  • Tissues
    18
  • cDNA Data
    20
  • Literature Summary
    2
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 231699 NCBI Gene Model | MGI Sequence Detail 9219 C57BL/6J ±  kb
transcript NM_145210 RefSeq | MGI Sequence Detail 1715 ZRU/MplStud  
polypeptide NP_001334379 RefSeq | MGI Sequence Detail 386 ZRU/MplStud  
For the selected sequence
Protein
Information
less
  • UniProt
    7 Sequences
  • InterPro Domains
    IPR006116 2-5OAS/ClassI-CCAase, nucleotidyltransferase domain
    IPR018952 2'-5'-oligoadenylate synthetase 1, domain 2/C-terminal
    IPR043519 Nucleotidyltransferase superfamily
Molecular
Reagents
less
  • All nucleic 26
    Genomic 5
    cDNA 20
    Primer pair 1

    Microarray probesets 2
Other
Accession IDs
less
MGI:2141342
References
more
  • Summaries
    All 37
    Developmental Gene Expression 2
    Gene Ontology 5
    Phenotypes 9
  • Earliest
    J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
  • Latest
    J:307968 He Y, et al., Single-cell RNA-Seq reveals a highly coordinated transcriptional program in mouse germ cells during primordial follicle formation. Aging Cell. 2021 Jul;20(7):e13424
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
09/08/2026
MGI 6.24 		The Jackson Laboratory