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Tnfsf15 Gene Detail
Summary
  • Symbol
    Tnfsf15
  • Name
    tumor necrosis factor (ligand) superfamily, member 15
  • Synonyms
    TL1, TL1A, VEGI
  • Feature Type
    protein coding gene
  • IDs
    MGI:2180140
    NCBI Gene: 326623
  • Alliance
    gene page
  • Transcription Start Sites
    11 TSS
Location &
Maps
more
  • Sequence Map
    Chr4:63642837-63663296 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 4, 34.06 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    230 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2180140
 protein coding gene Chr4:63642837-63663350 (-)
129S1/SvImJ MGP_129S1SvImJ_G0028373
 protein coding gene Chr4:62755543-62774122 (-)
A/J MGP_AJ_G0028334
 protein coding gene Chr4:60498390-60516415 (-)
AKR/J MGP_AKRJ_G0028283
 protein coding gene Chr4:62140245-62158263 (-)
BALB/cJ MGP_BALBcJ_G0028354
 protein coding gene Chr4:60686453-60704452 (-)
C3H/HeJ MGP_C3HHeJ_G0028069
 protein coding gene Chr4:62667438-62685463 (-)
C57BL/6NJ MGP_C57BL6NJ_G0028794
 protein coding gene Chr4:64892887-64912587 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0026097
 protein coding gene Chr4:57837842-57855872 (-)
CAST/EiJ MGP_CASTEiJ_G0027508
 protein coding gene Chr4:60669086-60686409 (-)
CBA/J MGP_CBAJ_G0028038
 protein coding gene Chr4:67181250-67199270 (-)
DBA/2J MGP_DBA2J_G0028187
 protein coding gene Chr4:60340175-60358141 (-)
FVB/NJ MGP_FVBNJ_G0028153
 protein coding gene Chr4:59625759-59643708 (-)
LP/J MGP_LPJ_G0028286
 protein coding gene Chr4:63050384-63068247 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0028182
 protein coding gene Chr4:70260958-70279796 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0028830
 protein coding gene Chr4:62261762-62279768 (-)
PWK/PhJ MGP_PWKPhJ_G0027237
 protein coding gene Chr4:58899250-58917469 (-)
SPRET/EiJ MGP_SPRETEiJ_G0027063
 protein coding gene Chr4:59729419-59747312 (-)
WSB/EiJ MGP_WSBEiJ_G0027587
 protein coding gene Chr4:62297026-62314977 (-)



Homology
more
  • Human Ortholog
    TNFSF15, TNF superfamily member 15
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TNFSF15, TNF superfamily member 15
  • Synonyms
    TL1, TL1A, TNLG1B, VEGI, VEGI192A
  • Links
    NCBI Gene ID: 9966
    neXtProt AC: NX_O95150
    UniProt: O95150

  • Chr Location
    9q32; chr9:114784635-114806039 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with Tnfsf15 mouse models

Human Disease Mouse Models
      
IDs
 View 2 models
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    2 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    28 phenotypes from 5 alleles in 4 genetic backgrounds
    22 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous targeted mutants display decreased clinical severity in experimental autoimmune encephalomyelitis (EAE) and collagen-induced arthritis.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    12
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    706
  • cDNA Data
    5
  • Literature Summary
    1
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 326623 NCBI Gene Model | MGI Sequence Detail 20460 C57BL/6J ±  kb
    transcript NM_177371 RefSeq | MGI Sequence Detail 5777 C57BL/6  
    polypeptide Q5UBV8 UniProt | EBI | MGI Sequence Detail 252 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 7
      Genomic 2
      cDNA 5

      Microarray probesets 1
    References
    more
    • Summaries
      All 64
      Developmental Gene Expression 1
      Diseases 1
      Gene Ontology 6
      Phenotypes 22
    • Earliest
      J:75557 Migone TS, et al., TL1A is a TNF-like ligand for DR3 and TR6/DcR3 and functions as a T cell costimulator. Immunity. 2002 Mar;16(3):479-92
    • Latest
      J:344363 Zhang D, et al., Identification of a novel role for TL1A/DR3 deficiency in acute respiratory distress syndrome that exacerbates alveolar epithelial disruption. Respir Res. 2023 Jul 11;24(1):182
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/16/2024
    MGI 6.23     		The Jackson Laboratory