Tnfsf15 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Tnfsf15
tumor necrosis factor (ligand) superfamily, member 15
MGI:2180140

28 phenotypes from 5 alleles in 4 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Tg(Csf1r-Tnfsf15,-EGFP)#Targ/0 involves: C57BL/6	abnormal ileum morphology	J:169462
	abnormal intestinal goblet cell morphology	J:169462
	abnormal joint morphology	J:169462
	blunted small intestinal villi	J:169462
	hemarthrosis	J:169462
	increased interferon-gamma secretion	J:169462
	increased Paneth cell number	J:169462
	intestinal fibrosis	J:169462
	joint swelling	J:169462
	skin lesions	J:169462
	small intestinal inflammation	J:169462
Tg(Lck-Tnfsf15,-EGFP)#Targ/0 involves: C57BL/6	abnormal ileum morphology	J:169462
	abnormal intestinal goblet cell morphology	J:169462
	abnormal joint morphology	J:169462
	blunted small intestinal villi	J:169462
	hemarthrosis	J:169462
	increased CD4-positive, alpha-beta memory T cell number	J:169462
	increased CD8-positive, alpha-beta memory T cell number	J:169462
	increased interferon-gamma secretion	J:169462
	increased interleukin-17 secretion	J:169462
	increased Paneth cell number	J:169462
	intestinal fibrosis	J:169462
	joint swelling	J:169462
	skin lesions	J:169462
	small intestinal inflammation	J:169462
Tnfsf15^tm1Cdon/Tnfsf15^tm1Cdon B6.129-Tnfsf15^tm1Cdon	abnormal dendritic cell differentiation	J:136280
Tnfsf15^tm1Cdon/Tnfsf15^tm1Cdon B6.129-Tnfsf15^tm1Cdon	decreased susceptibility to experimental autoimmune encephalomyelitis	J:136280
Tnfsf15^tm1Hluo/Tnfsf15^tm1Hluo D1LacJ.129(B6)-Tnfsf15^tm1Hluo	decreased B cell number	J:207029
	decreased germinal center B cell number	J:207029
	decreased IgG2a level	J:207029
	decreased IgG2b level	J:207029
	decreased IgG level	J:207029
	decreased plasma cell number	J:207029
	decreased susceptibility to induced arthritis	J:207029
	decreased T cell number	J:207029
	decreased T follicular helper cell number	J:207029
	normal immune system phenotype	J:207029
	lymph node hypoplasia	J:207029
Tnfsf15^tm1Lex/Tnfsf15^tm1Lex involves: 129S5/SvEvBrd * C57BL/6	increased NK cell number	J:82809

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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