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Adamts14 Gene Detail
Summary
  • Symbol
    Adamts14
  • Name
    ADAM metallopeptidase with thrombospondin type 1 motif 14
  • Synonyms
    Adamts-14, TS14
  • Feature Type
    protein coding gene
  • IDs
    MGI:2179942
    NCBI Gene: 237360
  • Alliance
    genome feature page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr10:61032891-61109217 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 10, 32.16 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    2294 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2179942
 protein coding gene Chr10:61032886-61109447 (-)
129S1/SvImJ ENSMUSG00200027990
 protein coding gene Chr10:57699059-57775430 (-)
A/J ENSMUSG00195024997
 protein coding gene Chr10:58011594-58087971 (-)
AKR/J ENSMUSG00220040220
 protein coding gene Chr10:57703757-57780137 (-)
BALB/cJ ENSMUSG00180022846
 protein coding gene Chr10:58053866-58130250 (-)
C3H/HeJ ENSMUSG00175024941
 protein coding gene Chr10:57906274-57982656 (-)
C57BL/6NJ ENSMUSG00215029393
 protein coding gene Chr10:57651979-57728367 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0015363
 protein coding gene Chr10:55689268-55768955 (-)
CAST/EiJ ENSTCUG00005026202
 protein coding gene Chr10:57700173-57776735 (-)
CBA/J ENSMUSG00210030650
 protein coding gene Chr10:57784582-57860955 (-)
DBA/2J ENSMUSG00185039430
 protein coding gene Chr10:58131373-58207756 (-)
FVB/NJ ENSMUSG00205026088
 protein coding gene Chr10:57804975-57881369 (-)
JF1/MsJ ENSUMUG00000020674
 protein coding gene Chr10:59365717-59441668 (-)
LP/J ENSMUSG00230019485
 protein coding gene Chr10:59934495-60010854 (-)
NOD/ShiLtJ ENSMUSG00190032730
 protein coding gene Chr10:58117138-58193517 (-)
NZO/HlLtJ ENSMUSG00225044521
 protein coding gene Chr10:64215435-64291805 (-)
PWK/PhJ ENSLUMG00010021398
 protein coding gene Chr10:57722435-57799089 (-)
SPRET/EiJ ENSMSPG00010023916
 protein coding gene Chr10:59324809-59400364 (-)
WSB/EiJ ENSIUOG00005038366
 protein coding gene Chr10:57688674-57765061 (-)



Homology
more
  • Human Ortholog
    ADAMTS14, ADAM metallopeptidase with thrombospondin type 1 motif 14
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ADAMTS14, ADAM metallopeptidase with thrombospondin type 1 motif 14
  • Links
    NCBI Gene ID: 140766
    UniProt: Q8WXS8

  • Chr Location
    10q22.1; chr10:70672367-70762441 (+)  GRCh38
Human Diseases
more
  • Diseases
    3 with human ADAMTS14 associations

Human Disease Mouse Models
      
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    8 phenotypes from 2 alleles in 3 genetic backgrounds
    24 phenotypes from multigenic genotypes
    22 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele are viable, healthy and fertile and exhibit normal aminoprocollagen processing.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    11
  • GO References
    3
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    617
  • Tissues
    2
  • cDNA Data
    17
  • Literature Summary
    4
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000059901 Ensembl Gene Model | MGI Sequence Detail 76327 C57BL/6J ±  kb
    transcript ENSMUST00000120336 Ensembl | MGI Sequence Detail 3645 Not Applicable  
    polypeptide ENSMUSP00000112723 Ensembl | MGI Sequence Detail 1209 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 18
      cDNA 17
      Primer pair 1

      Microarray probesets 1
    References
    more
    • Summaries
      All 44
      Developmental Gene Expression 4
      Gene Ontology 3
      Phenotypes 22
    • Earliest
      J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
    • Latest
      J:351385 Kaneko N, et al., ADAMTS2 promotes radial migration by activating TGF-beta signaling in the developing neocortex. EMBO Rep. 2024 Jul;25(7):3090-3115
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/01/2026
    MGI 6.24     		The Jackson Laboratory