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Srgap3 Gene Detail
Summary
  • Symbol
    Srgap3
  • Name
    SLIT-ROBO Rho GTPase activating protein 3
  • Synonyms
    Arhgap14, D130026O08Rik, mKIAA0411
  • Feature Type
    protein coding gene
  • IDs
    MGI:2152938
    NCBI Gene: 259302
  • Alliance
    gene page
  • Transcription Start Sites
    7 TSS
Location &
Maps
more
  • Sequence Map
    Chr6:112694932-112924227 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 6, 52.54 cM, cytoband E3
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    13607 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2152938
 protein coding gene Chr6:112694932-112924466 (-)
129S1/SvImJ MGP_129S1SvImJ_G0031110
 protein coding gene Chr6:115174455-115417373 (-)
A/J MGP_AJ_G0031079
 protein coding gene Chr6:110774348-111010492 (-)
AKR/J MGP_AKRJ_G0031010
 protein coding gene Chr6:113761616-113998464 (-)
BALB/cJ MGP_BALBcJ_G0031090
 protein coding gene Chr6:110730140-110962555 (-)
C3H/HeJ MGP_C3HHeJ_G0030618
 protein coding gene Chr6:70303982-70544916 (+)
C57BL/6NJ MGP_C57BL6NJ_G0031549
 protein coding gene Chr6:118173162-118425959 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0028713
 protein coding gene Chr6:107795944-108026256 (-)
CAST/EiJ MGP_CASTEiJ_G0030197
 protein coding gene Chr6:114181993-114421768 (-)
CBA/J MGP_CBAJ_G0030776
 protein coding gene Chr6:122846694-123096206 (-)
DBA/2J MGP_DBA2J_G0030929
 protein coding gene Chr6:109872452-110101744 (-)
FVB/NJ MGP_FVBNJ_G0030883
 protein coding gene Chr6:108863918-109093839 (-)
LP/J MGP_LPJ_G0031009
 protein coding gene Chr6:115228391-115470702 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0030917
 protein coding gene Chr6:127145916-127389471 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0031576
 protein coding gene Chr6:113769338-114010549 (-)
PWK/PhJ MGP_PWKPhJ_G0029913
 protein coding gene Chr6:108809538-109042151 (-)
SPRET/EiJ MGP_SPRETEiJ_G0029741
 protein coding gene Chr6:112576839-112825536 (-)
WSB/EiJ MGP_WSBEiJ_G0030281
 protein coding gene Chr6:114140559-114380520 (-)



Homology
more
  • Human Ortholog
    SRGAP3, SLIT-ROBO Rho GTPase activating protein 3
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SRGAP3, SLIT-ROBO Rho GTPase activating protein 3
  • Synonyms
    ARHGAP14, MEGAP, SRGAP2, WRP
  • Links
    NCBI Gene ID: 9901
    UniProt: O43295

  • Chr Location
    3p25.3; chr3:8980591-9363053 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with Srgap3 mouse models

Human Disease Mouse Models
      
IDs
 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    21 phenotypes from 3 alleles in 4 genetic backgrounds
    15 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit a reduction in spine density in the brain CA1 and cortical layers IV/V. Mice homozygous for a different knock-out allele exhibit a neurodevelopment disorder with schizophrenia-related intermediate phenotypes.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    13
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1070
  • Tissues
    254
  • cDNA Data
    118
  • Literature Summary
    9
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000030257 Ensembl Gene Model | MGI Sequence Detail 229296 C57BL/6J ±  kb
    transcript ENSMUST00000088373 Ensembl | MGI Sequence Detail 8887 Not Applicable  
    polypeptide ENSMUSP00000085712 Ensembl | MGI Sequence Detail 1099 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 122
      cDNA 119
      Primer pair 2
      Other 1

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGI:1889839, MGI:2442214
    References
    more
    • Summaries
      All 53
      Developmental Gene Expression 9
      Diseases 1
      Gene Ontology 7
      Phenotypes 15
    • Earliest
      J:72329 Wong K, et al., Signal transduction in neuronal migration. roles of gtpase activating proteins and the small gtpase cdc42 in the slit-robo pathway. Cell. 2001 Oct 19;107(2):209-21
    • Latest
      J:333727 Rogg M, et al., SRGAP1 Controls Small Rho GTPases To Regulate Podocyte Foot Process Maintenance. J Am Soc Nephrol. 2021 Mar;32(3):563-579
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    03/25/2025
    MGI 6.24     		The Jackson Laboratory