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Taar1 Gene Detail
Summary
  • Symbol
    Taar1
  • Name
    trace amine-associated receptor 1
  • Synonyms
    Tar1, Trar1
  • Feature Type
    protein coding gene
  • IDs
    MGI:2148258
    NCBI Gene: 111174
  • Alliance
    gene page
Location &
Maps
more
  • Sequence Map
    Chr10:23796304-23797302 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 10, 11.39 cM, cytoband A3
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    15 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2148258
 protein coding gene Chr10:23796254-23797367 (+)
129S1/SvImJ MGP_129S1SvImJ_G0017076
 protein coding gene Chr10:21851357-21852470 (+)
A/J MGP_AJ_G0017054
 protein coding gene Chr10:21212358-21213471 (+)
AKR/J MGP_AKRJ_G0017016
 protein coding gene Chr10:21558504-21559617 (+)
BALB/cJ MGP_BALBcJ_G0017016
 protein coding gene Chr10:21285158-21286271 (+)
C3H/HeJ MGP_C3HHeJ_G0016836
 protein coding gene Chr10:21764824-21765937 (+)
C57BL/6NJ MGP_C57BL6NJ_G0017474
 protein coding gene Chr10:22504496-22505609 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0015175
 protein coding gene Chr10:19940261-19941374 (+)
CAST/EiJ MGP_CASTEiJ_G0016417
 protein coding gene Chr10:21655113-21656226 (+)
CBA/J MGP_CBAJ_G0016809
 protein coding gene Chr10:23507091-23508204 (+)
DBA/2J MGP_DBA2J_G0016915
 protein coding gene Chr10:20954014-20955127 (+)
FVB/NJ MGP_FVBNJ_G0016911
 protein coding gene Chr10:20667844-20668957 (+)
LP/J MGP_LPJ_G0016991
 protein coding gene Chr10:21838823-21839936 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0016941
 protein coding gene Chr10:23641709-23642822 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0017509
 protein coding gene Chr10:21425691-21426804 (+)
PWK/PhJ MGP_PWKPhJ_G0016202
 protein coding gene Chr10:20687121-20688234 (+)
SPRET/EiJ MGP_SPRETEiJ_G0015984
 protein coding gene Chr10:21237002-21238115 (+)
WSB/EiJ MGP_WSBEiJ_G0016480
 protein coding gene Chr10:21525756-21526869 (+)



Homology
more
  • Human Ortholog
    TAAR1, trace amine associated receptor 1
  • Vertebrate Orthologs
    7
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TAAR1, trace amine associated receptor 1
  • Synonyms
    TA1, TAR1, TRAR1
  • Links
    NCBI Gene ID: 134864
    neXtProt AC: NX_Q96RJ0
    UniProt: Q96RJ0

  • Chr Location
    6q23.2; chr6:132643312-132659182 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with Taar1 mouse models

Human Disease Mouse Models
      
IDs
 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    14 phenotypes from 6 alleles in 7 genetic backgrounds
    28 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null mutation display decreased prepulse inhibition and increased sensitivity to amphetamines. Mice homozygous for another knock-out allele exhibit increased sensitivity to MDMA-induced hyperthermia, brain dopamine and serotonin levels, and induced hyperactivity.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    13
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    708
  • Tissues
    2
  • cDNA Data
    6
  • Literature Summary
    1
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 111174 NCBI Gene Model | MGI Sequence Detail 999 C57BL/6J ±  kb
transcript NM_053205 RefSeq | MGI Sequence Detail 999 129X1/SvJ  
polypeptide Q923Y8 UniProt | EBI | MGI Sequence Detail 332 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 7
    cDNA 6
    Primer pair 1

    Microarray probesets 2
References
more
  • Summaries
    All 57
    Developmental Gene Expression 1
    Diseases 1
    Gene Ontology 6
    Phenotypes 28
  • Earliest
    J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
  • Latest
    J:343375 Shang P, et al., Structural and signaling mechanisms of TAAR1 enabled preferential agonist design. Cell. 2023 Nov 22;186(24):5347-5362.e24
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
04/16/2024
MGI 6.23 		The Jackson Laboratory