Marveld1 MGI Mouse Gene Detail - MGI:2147570 - MARVEL (membrane-associating) domain containing 1

Symbol

Marveld1
Name

MARVEL (membrane-associating) domain containing 1
Synonyms

Mrvldc1

Feature Type

protein coding gene
IDs

MGI:2147570
NCBI Gene: 277010
Alliance

gene page
Transcription Start Sites

4 TSS

Sequence Map

Chr19:42135879-42140137 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 19, 35.84 cM
Mapping Data

1 experiment

SNPs within 2kb

23 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2147570	protein coding gene	Chr19:42135839-42140142 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0025141	protein coding gene	Chr19:41470257-41474568 (+)
A/J	MGP_AJ_G0025118	protein coding gene	Chr19:39474139-39478469 (+)
AKR/J	MGP_AKRJ_G0025086	protein coding gene	Chr19:40766142-40770489 (+)
BALB/cJ	MGP_BALBcJ_G0025112	protein coding gene	Chr19:39540958-39545279 (+)
C3H/HeJ	MGP_C3HHeJ_G0024872	protein coding gene	Chr19:40916022-40920333 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0025555	protein coding gene	Chr19:42535512-42539815 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0022969	protein coding gene	Chr19:38829694-38834166 (+)
CAST/EiJ	MGP_CASTEiJ_G0024337	protein coding gene	Chr19:40598366-40602710 (+)
CBA/J	MGP_CBAJ_G0024852	protein coding gene	Chr19:44614451-44618762 (+)
DBA/2J	MGP_DBA2J_G0024984	protein coding gene	Chr19:39322812-39327133 (+)
FVB/NJ	MGP_FVBNJ_G0024945	protein coding gene	Chr19:39096935-39101577 (+)
LP/J	MGP_LPJ_G0025070	protein coding gene	Chr19:41456561-41460872 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0024976	protein coding gene	Chr19:44237252-44241554 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0025613	protein coding gene	Chr19:40811885-40816187 (+)
PWK/PhJ	MGP_PWKPhJ_G0024086	protein coding gene	Chr19:39206144-39210469 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0023890	protein coding gene	Chr19:39552599-39556873 (+)
WSB/EiJ	MGP_WSBEiJ_G0024407	protein coding gene	Chr19:40962965-40967276 (+)

Human Ortholog

MARVELD1, MARVEL domain containing 1

Vertebrate Orthologs

2

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

MARVELD1, MARVEL domain containing 1
Synonyms

bA548K23.8, GB14, MARVD1, MRVLDC1
Links

HGNC:28674

NCBI Gene ID: 83742

neXtProt AC: NX_Q9BSK0

UniProt: Q9BSK0
Chr Location

10q24.2; chr10:97713173-97718150 (+) GRCh38

MGI Vertebrate Homology

Marveld1 stringent orthology
1 human;1 mouse;1 zebrafish
HCOP

vertebrate homology predictions: MARVELD1
Gene Tree

Marveld1

less

Phenotype Summary

24 phenotypes from 2 alleles in 3 genetic backgrounds
3 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

9
Gene trapped

7
Targeted

2
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

4 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

less

All GO Annotations

8
GO References

3

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

less

Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

719
Tissues

7
cDNA Data

61
Literature Summary

2

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase marveld1

ZFIN marveld1

less

All Sequences

37
RefSeq

2
UniProt

2
CCDS

CCDS50439.1

Ensembl

ENSMUSG00000044345 (Evidence)
NCBI Gene

277010

			Length	Strain/Species	Flank
genomic	277010	NCBI Gene Model \| MGI Sequence Detail	4259	C57BL/6J	± kb
transcript	NM_183195	RefSeq \| MGI Sequence Detail	3021	C57BL/6
polypeptide	Q7TQJ1	UniProt \| EBI \| MGI Sequence Detail	173	Not Applicable

less

UniProt

2 Sequences
Protein Ontology

PR:000032194 MARVEL domain-containing protein 1

(term hierarchy)
InterPro Domains

IPR008253 Marvel domain

less

All nucleic 62

cDNA 61

Primer pair 1

Microarray probesets 5

Summaries

All 25

Developmental Gene Expression 2

Gene Ontology 3

Phenotypes 3
Earliest

J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
Latest

J:280829 Chen Y, et al., The depletion of MARVELD1 leads to murine placenta accreta via integrin beta4-dependent trophoblast cell invasion. J Cell Physiol. 2018 Mar;233(3):2257-2269

TSS for Marveld1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr156484	Chr19:42135812-42135827 (+)	-59 bp
Tssr156485	Chr19:42135852-42135865 (+)	-20 bp
Tssr156486	Chr19:42135871-42135893 (+)	3 bp
Tssr5518	Chr19:42135905-42135910 (+)	29 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 04/16/2024 MGI 6.23