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Vipas39 Gene Detail
Summary
  • Symbol
    Vipas39
  • Name
    VPS33B interacting protein, apical-basolateral polarity regulator, spe-39 homolog
  • Synonyms
    SPE-39, Vipar
  • Feature Type
    protein coding gene
  • IDs
    MGI:2144805
    NCBI Gene: 104799
  • Alliance
    gene page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr12:87285642-87313030 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 12, 41.44 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    97 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2144805
 protein coding gene Chr12:87285642-87313426 (-)
129S1/SvImJ MGP_129S1SvImJ_G0019983
 protein coding gene Chr12:88138889-88165930 (-)
A/J MGP_AJ_G0019941
 protein coding gene Chr12:84789143-84817112 (-)
AKR/J MGP_AKRJ_G0019916
 protein coding gene Chr12:87093924-87121845 (-)
BALB/cJ MGP_BALBcJ_G0019920
 protein coding gene Chr12:85122606-85150298 (-)
C3H/HeJ MGP_C3HHeJ_G0019726
 protein coding gene Chr12:87582624-87610980 (-)
C57BL/6NJ MGP_C57BL6NJ_G0020372
 protein coding gene Chr12:90678432-90708383 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0017990
 protein coding gene Chr12:81667311-81697062 (-)
CAST/EiJ MGP_CASTEiJ_G0019276
 protein coding gene Chr12:82606334-82641504 (-)
CBA/J MGP_CBAJ_G0019698
 protein coding gene Chr12:94152368-94179707 (-)
DBA/2J MGP_DBA2J_G0019811
 protein coding gene Chr12:84284651-84312742 (-)
FVB/NJ MGP_FVBNJ_G0019798
 protein coding gene Chr12:83277603-83306859 (-)
LP/J MGP_LPJ_G0019885
 protein coding gene Chr12:88018590-88046910 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0019837
 protein coding gene Chr12:96915185-96942607 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0020404
 protein coding gene Chr12:86720977-86748307 (-)
PWK/PhJ MGP_PWKPhJ_G0019040
 protein coding gene Chr12:78838841-78866991 (-)
SPRET/EiJ MGP_SPRETEiJ_G0018835
 protein coding gene Chr12:81228967-81255995 (-)
WSB/EiJ MGP_WSBEiJ_G0019329
 protein coding gene Chr12:87496502-87526013 (-)



Homology
more
  • Human Ortholog
    VIPAS39, VPS33B interacting protein, apical-basolateral polarity regulator, spe-39 homolog
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    VIPAS39, VPS33B interacting protein, apical-basolateral polarity regulator, spe-39 homolog
  • Synonyms
    C14orf133, hSPE-39, SPE39, SPE-39, VIPAR, VPS16B
  • Links
    NCBI Gene ID: 63894
    neXtProt AC: NX_Q9H9C1
    UniProt: Q9H9C1

  • Chr Location
    14q24.3; chr14:77426675-77457952 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with Vipas39 mouse models; 1 with human VIPAS39 associations

Human Disease Mouse Models
      
IDs
 View 1 model
      
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    5 phenotypes from 1 allele in 1 genetic background
    2 images
    9 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a conditional allele activated by an inducible cre exhibit dry and scaly skin, hair loss, and defects in tail tendon collagen I structure.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    29
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    723
  • Tissues
    11
  • cDNA Data
    87
  • Literature Summary
    1
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000021038 Ensembl Gene Model | MGI Sequence Detail 27389 C57BL/6J ±  kb
    transcript ENSMUST00000072744 Ensembl | MGI Sequence Detail 2524 Not Applicable  
    polypeptide ENSMUSP00000072527 Ensembl | MGI Sequence Detail 491 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 88
      cDNA 88

      Microarray probesets 3
    References
    more
    • Summaries
      All 37
      Developmental Gene Expression 1
      Diseases 1
      Gene Ontology 7
      Phenotypes 9
    • Earliest
      J:86696 Zambrowicz BP, et al., Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Proc Natl Acad Sci U S A. 2003 Nov 25;100(24):14109-14
    • Latest
      J:318904 Rogerson C, et al., VPS33B and VIPAR are essential for epidermal lamellar body biogenesis and function. Biochim Biophys Acta Mol Basis Dis. 2018 May;1864(5 Pt A):1609-1621
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/16/2024
    MGI 6.23     		The Jackson Laboratory