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Targeted Allele Detail
Symbol: Vipas39tm1c(KOMP)Mbp
Name: VPS33B interacting protein, apical-basolateral polarity regulator, spe-39 homolog; targeted mutation 1c, Mouse Biology Program, UC Davis
MGI ID: MGI:5816979
Synonyms: Vipas39fl
Gene: Vipas39  Location: Chr12:87285642-87313030 bp, - strand  Genetic Position: Chr12, 41.44 cM
Alliance: Vipas39tm1c(KOMP)Mbp page
IMPC: Vipas39 gene page
Abnormal collagen structure in Vipas39tm1c(KOMP)Mbp/Vipas39tm1c(KOMP)Mbp Gt(ROSA)26Sortm1(cre/ERT2)Tyj/Gt(ROSA)26Sor+, and Vps33btm1.1Arte/Vps33btm1.1Arte Gt(ROSA)26Sortm1(cre/ERT2)Tyj/Gt(ROSA)26Sor+ mouse tail tendon

Show the 2 phenotype image(s) involving this allele.

Germline Transmission:  Earliest citation of germline transmission: J:236095
Parent Cell Line:  JM8A3.N1 (ES Cell)
Strain of Origin:  C57BL/6N-Atm1Brd
Project Collection: KOMP-CSD
Allele Type:    Targeted (Conditional ready)
Mutation:    Insertion
Mutation detailsThe L1L2_Bact_P cassette was inserted at position 87298249 of Chromosome 12 upstream of the critical exon(s) (Build GRCm39). The cassette is composed of an FRT site followed by lacZ sequence and a loxP site. This first loxP site is followed by neomycin resistance gene under the control of the human beta-actin promoter, SV40 polyA, a second FRT site and a second loxP site. A third loxP site is inserted downstream of the targeted exon(s) at position 87299141. The critical exon 10 is thus flanked by loxP sites. A "conditional ready" (floxed) allele was created by flp recombinase expression in mice carrying this allele to remove the lacZ sequence and neo selection cassette, leaving loxP sites flanking exon 10. (J:236095)
View phenotypes and curated references for all genotypes (concatenated display).
Disease models
In Structures Affected by this Mutation: 1 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Vipas39 Mutation:  31 strains or lines available
Original:  J:236095 Banushi B, et al., Regulation of post-Golgi LH3 trafficking is essential for collagen homeostasis. Nat Commun. 2016 Jul 20;7:12111
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
MGI 6.13
The Jackson Laboratory