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Pds5b Gene Detail
Summary
  • Symbol
    Pds5b
  • Name
    PDS5 cohesin associated factor B
  • Synonyms
    Aprin, AS3, mKIAA0979
  • Feature Type
    protein coding gene
  • IDs
    MGI:2140945
    NCBI Gene: 100710
  • Alliance
    genome feature page
  • Transcription Start Sites
    10 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:150597204-150734155 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 5, 89.61 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    2485 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2140945
 protein coding gene Chr5:150597178-150734174 (+)
129S1/SvImJ ENSMUSG00200010227
 protein coding gene Chr5:144437900-144574856 (+)
A/J ENSMUSG00195004919
 protein coding gene Chr5:144055579-144192572 (+)
AKR/J ENSMUSG00220015221
 protein coding gene Chr5:143062661-143199675 (+)
BALB/cJ ENSMUSG00180002931
 protein coding gene Chr5:144457892-144594867 (+)
C3H/HeJ ENSMUSG00175011238
 protein coding gene Chr5:146298620-146435597 (+)
C57BL/6NJ ENSMUSG00215000045
 protein coding gene Chr5:143988740-144125723 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0028063
 protein coding gene Chr5:144234452-144369565 (+)
CAST/EiJ ENSTCUG00005009677
 protein coding gene Chr5:143567716-143704221 (+)
CBA/J ENSMUSG00210000496
 protein coding gene Chr5:145178755-145315723 (+)
DBA/2J ENSMUSG00185038124
 protein coding gene Chr5:148155327-148292307 (+)
FVB/NJ ENSMUSG00205000130
 protein coding gene Chr5:143837617-143974631 (+)
JF1/MsJ ENSUMUG00000031299
 protein coding gene Chr5:150653345-150791432 (+)
LP/J ENSMUSG00230001116
 protein coding gene Chr5:152154479-152291439 (+)
NOD/ShiLtJ ENSMUSG00190005628
 protein coding gene Chr5:143804793-143941806 (+)
NZO/HlLtJ ENSMUSG00225008623
 protein coding gene Chr5:159901055-160038023 (+)
PWK/PhJ ENSLUMG00010000396
 protein coding gene Chr5:142909548-143046950 (+)
SPRET/EiJ ENSMSPG00010005871
 protein coding gene Chr5:145699215-145841986 (+)
WSB/EiJ ENSIUOG00005013522
 protein coding gene Chr5:146577689-146717965 (+)



Homology
more
  • Human Ortholog
    PDS5B, PDS5 cohesin associated factor B
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PDS5B, PDS5 cohesin associated factor B
  • Synonyms
    APRIN, AS3, CG008
  • Links
    NCBI Gene ID: 23047
    UniProt: Q9NTI5

  • Chr Location
    13q13.1; chr13:32586315-32778022 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    52 phenotypes from 2 alleles in 2 genetic backgrounds
    21 phenotypes from multigenic genotypes
    2 images
    30 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele exhibit embryonic and neonatal lethality with cardiac defects, craniofacial abnormalities, axial skeletal defects, shortening of most of the long bones, abnormal enteric nervous system morphology, and decreased germ cells.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    20
  • GO References
    9
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    815
  • Tissues
    118
  • cDNA Data
    17
  • Literature Summary
    4
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000034021 Ensembl Gene Model | MGI Sequence Detail 136952 C57BL/6J ±  kb
    transcript ENSMUST00000038900 Ensembl | MGI Sequence Detail 7315 Not Applicable  
    polypeptide ENSMUSP00000038421 Ensembl | MGI Sequence Detail 1449 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      2 Sequences
    • Protein Ontology
      PR:000012520 sister chromatid cohesion protein PDS5 homolog B
      (term hierarchy)
    • InterPro Domains
      IPR011989 Armadillo-like helical
      IPR016024 Armadillo-type fold
      IPR039776 Sister chromatid cohesion protein Pds5
    • GlyGen
      Q4VA53 2 sites, 3 N-linked glycans (1 site), 1 O-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 24
      Genomic 2
      cDNA 17
      Primer pair 3
      Other 2
      Antibodies 1

      Microarray probesets 7
    Other
    Accession IDs
    less
    MGI:2141177, MGI:3850476
    References
    more
    • Summaries
      All 65
      Developmental Gene Expression 4
      Gene Ontology 9
      Phenotypes 30
    • Earliest
      J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
    • Latest
      J:360588 Troise F, et al., Prime and pull of T cell responses against cancer-exogenous antigens is effective against CPI-resistant tumors. Mol Ther Oncol. 2024 Mar 21;32(1):200760
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    09/01/2026
    MGI 6.24     		The Jackson Laboratory