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Suco Gene Detail
Summary
  • Symbol
    Suco
  • Name
    SUN domain containing ossification factor
  • Synonyms
    AI848100, Opt, osteopotentia
  • Feature Type
    protein coding gene
  • IDs
    MGI:2138346
    NCBI Gene: 226551
  • Alliance
    genome feature page
  • Transcription Start Sites
    11 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:161643683-161704251 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 1, 69.95 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1130 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2138346
 protein coding gene Chr1:161643681-161704506 (-)
129S1/SvImJ ENSMUSG00200005195
 protein coding gene Chr1:159148588-159209172 (-)
A/J ENSMUSG00195018851
 protein coding gene Chr1:158464843-158525435 (-)
AKR/J ENSMUSG00220013182
 protein coding gene Chr1:158254486-158315069 (-)
BALB/cJ ENSMUSG00180034482
 protein coding gene Chr1:158727835-158789347 (-)
C3H/HeJ ENSMUSG00175039210
 protein coding gene Chr1:158783565-158844133 (-)
C57BL/6NJ ENSMUSG00215015593
 protein coding gene Chr1:158662695-158723265 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0014767
 protein coding gene Chr1:152408725-152471631 (-)
CAST/EiJ ENSTCUG00005020225
 protein coding gene Chr1:157314218-157374714 (-)
CBA/J ENSMUSG00210020297
 protein coding gene Chr1:158681584-158742168 (-)
DBA/2J ENSMUSG00185010918
 protein coding gene Chr1:162945291-163006813 (-)
FVB/NJ ENSMUSG00205009870
 protein coding gene Chr1:157749505-157810087 (-)
JF1/MsJ ENSUMUG00000009190
 protein coding gene Chr1:162106446-162168006 (-)
LP/J ENSMUSG00230011893
 protein coding gene Chr1:162546423-162607006 (-)
NOD/ShiLtJ ENSMUSG00190024203
 protein coding gene Chr1:158501215-158561787 (-)
NZO/HlLtJ ENSMUSG00225004041
 protein coding gene Chr1:166154045-166214615 (-)
PWK/PhJ ENSLUMG00010037361
 protein coding gene Chr1:157488909-157550385 (-)
SPRET/EiJ ENSMSPG00010041943
 protein coding gene Chr1:160875349-160934922 (-)
WSB/EiJ ENSIUOG00005015209
 protein coding gene Chr1:158060022-158120608 (-)



Homology
more
  • Human Ortholog
    SUCO, SUN domain containing ossification factor
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SUCO, SUN domain containing ossification factor
  • Synonyms
    C1orf9, CH1, OPT, SLP1
  • Links
    NCBI Gene ID: 51430
    UniProt: Q9UBS9

  • Chr Location
    1q24.3; chr1:172532349-172611833 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with Suco mouse models

Human Disease Mouse Models
      
IDs
 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    47 phenotypes from 2 alleles in 3 genetic backgrounds
    3 images
    14 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a mutation in this gene display background strain-dependent neonatal and postnatal lethality, and impaired osteoblast differentiation resulting in impaired bone formation, brittle bones, and impaired fracture repair.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    10
  • GO References
    4
Molecular Function

No experimental evidence to support Molecular Function annotation, following literature review. See J:73796.
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    623
  • Tissues
    15
  • cDNA Data
    87
  • Literature Summary
    1
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000040297 Ensembl Gene Model | MGI Sequence Detail 60569 C57BL/6J ±  kb
    transcript ENSMUST00000048377 Ensembl | MGI Sequence Detail 6327 Not Applicable  
    polypeptide ENSMUSP00000044815 Ensembl | MGI Sequence Detail 1254 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      4 Sequences
    • Protein Ontology
      PR:000032354 SUN domain-containing ossification factor
      (term hierarchy)
    • InterPro Domains
      IPR008979 Galactose-binding-like domain superfamily
      IPR012919 SUN domain
      IPR045120 SUN domain-containing Suco/Slp1-like
    • GlyGen
      Q8C341 12 sites, 12 N-linked glycans (11 sites), 1 O-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 89
      cDNA 87
      Primer pair 1
      Other 1
      Antibodies 1

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGI:2138413
    References
    more
    • Summaries
      All 39
      Developmental Gene Expression 1
      Diseases 1
      Gene Ontology 4
      Phenotypes 14
    • Earliest
      J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/15/2026
    MGI 6.29     		The Jackson Laboratory