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Suco Gene Detail
Summary
  • Symbol
    Suco
  • Name
    SUN domain containing ossification factor
  • Synonyms
    AI848100, Opt, osteopotentia
  • Feature Type
    protein coding gene
  • IDs
    MGI:2138346
    NCBI Gene: 226551
  • Alliance
    gene page
  • Transcription Start Sites
    11 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:161643683-161704251 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 1, 69.95 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    368 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2138346
 protein coding gene Chr1:161643681-161704506 (-)
129S1/SvImJ MGP_129S1SvImJ_G0016655
 protein coding gene Chr1:167125430-167186705 (-)
A/J MGP_AJ_G0016636
 protein coding gene Chr1:160318112-160380448 (-)
AKR/J MGP_AKRJ_G0016602
 protein coding gene Chr1:165189756-165251483 (-)
BALB/cJ MGP_BALBcJ_G0016597
 protein coding gene Chr1:160868294-160929013 (-)
C3H/HeJ MGP_C3HHeJ_G0016421
 protein coding gene Chr1:165397014-165459293 (-)
C57BL/6NJ MGP_C57BL6NJ_G0017058
 protein coding gene Chr1:172770545-172837636 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0014767
 protein coding gene Chr1:152408725-152471631 (-)
CAST/EiJ MGP_CASTEiJ_G0016001
 protein coding gene Chr1:165034717-165098331 (-)
CBA/J MGP_CBAJ_G0016396
 protein coding gene Chr1:178912665-178982537 (-)
DBA/2J MGP_DBA2J_G0016502
 protein coding gene Chr1:159283989-159346726 (-)
FVB/NJ MGP_FVBNJ_G0016500
 protein coding gene Chr1:157692718-157753478 (-)
LP/J MGP_LPJ_G0016573
 protein coding gene Chr1:168230081-168301869 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0016525
 protein coding gene Chr1:186431848-186521861 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0017094
 protein coding gene Chr1:165035998-165099744 (-)
PWK/PhJ MGP_PWKPhJ_G0015787
 protein coding gene Chr1:158460812-158522897 (-)
SPRET/EiJ MGP_SPRETEiJ_G0015574
 protein coding gene Chr1:163917225-163977806 (-)
WSB/EiJ MGP_WSBEiJ_G0016063
 protein coding gene Chr1:165202130-165264041 (-)



Homology
more
  • Human Ortholog
    SUCO, SUN domain containing ossification factor
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SUCO, SUN domain containing ossification factor
  • Synonyms
    C1orf9, CH1, OPT, SLP1
  • Links
    NCBI Gene ID: 51430
    neXtProt AC: NX_Q9UBS9
    UniProt: Q9UBS9

  • Chr Location
    1q24.3; chr1:172532349-172611833 (+)  GRCh38.p7
Human Diseases
more
  • Diseases
    1 with Suco mouse models

Human Disease Mouse Models
      
IDs
 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    48 phenotypes from 2 alleles in 3 genetic backgrounds
    3 images
    12 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a mutation in this gene display background strain-dependent neonatal and postnatal lethality, and impaired osteoblast differentiation resulting in impaired bone formation, brittle bones, and impaired fracture repair.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    11
  • GO References
    3
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    706
  • cDNA Data
    87
  • Literature Summary
    1
  • Comparison Matrix
    Gene Expression + Phenotype
    • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000040297 Ensembl Gene Model | MGI Sequence Detail 60569 C57BL/6J ±  kb
    transcript ENSMUST00000048377 Ensembl | MGI Sequence Detail 6327 Not Applicable  
    polypeptide ENSMUSP00000044815 Ensembl | MGI Sequence Detail 1254 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 87
      cDNA 87

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGI:2138413
    References
    more
    • Summaries
      All 35
      Developmental Gene Expression 1
      Diseases 1
      Gene Ontology 3
      Phenotypes 12
    • Earliest
      J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
    • Latest
      J:265628 Gaudet P, et al., Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief Bioinform. 2011 Sep;12(5):449-62
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    05/24/2023
    MGI 6.22     		The Jackson Laboratory