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Cadm3 Gene Detail
Summary
  • Symbol
    Cadm3
  • Name
    cell adhesion molecule 3
  • Synonyms
    BIgR, Igsf4b, Necl1, Necl-1, SynCAM3, Tsll1
  • Feature Type
    protein coding gene
  • IDs
    MGI:2137858
    NCBI Gene: 94332
  • Alliance
    gene page
  • Transcription Start Sites
    7 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:173160825-173195261 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 1, 80.33 cM, cytoband H3
  • Mapping Data
    5 experiments
Strain
Comparison
more
  • SNPs within 2kb
    323 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2137858
 protein coding gene Chr1:173159459-173195705 (-)
129S1/SvImJ MGP_129S1SvImJ_G0016808
 protein coding gene Chr1:179263770-179298166 (-)
A/J MGP_AJ_G0016785
 protein coding gene Chr1:171914379-171949045 (-)
AKR/J MGP_AKRJ_G0016751
 protein coding gene Chr1:177139388-177174355 (-)
BALB/cJ MGP_BALBcJ_G0016745
 protein coding gene Chr1:172456935-172491369 (-)
C3H/HeJ MGP_C3HHeJ_G0016570
 protein coding gene Chr1:177668784-177703232 (-)
C57BL/6NJ MGP_C57BL6NJ_G0017208
 protein coding gene Chr1:185236816-185274946 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0014914
 protein coding gene Chr1:163542183-163576161 (-)
CAST/EiJ MGP_CASTEiJ_G0016150
 protein coding gene Chr1:177063907-177101487 (-)
CBA/J MGP_CBAJ_G0016544
 protein coding gene Chr1:191846059-191882648 (-)
DBA/2J MGP_DBA2J_G0016651
 protein coding gene Chr1:170875455-170910988 (-)
FVB/NJ MGP_FVBNJ_G0016648
 protein coding gene Chr1:169086530-169125915 (-)
LP/J MGP_LPJ_G0016722
 protein coding gene Chr1:180337625-180372056 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0016674
 protein coding gene Chr1:199061685-199096354 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0017244
 protein coding gene Chr1:177032328-177067797 (-)
PWK/PhJ MGP_PWKPhJ_G0015937
 protein coding gene Chr1:170236906-170271588 (-)
SPRET/EiJ MGP_SPRETEiJ_G0015719
 protein coding gene Chr1:175962500-176005241 (-)
WSB/EiJ MGP_WSBEiJ_G0016214
 protein coding gene Chr1:177129218-177165558 (-)



Homology
more
  • Human Ortholog
    CADM3, cell adhesion molecule 3
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CADM3, cell adhesion molecule 3
  • Synonyms
    BIgR, CMT2FF, IGSF4B, Necl-1, NECL1, synCAM3, TSLL1
  • Links
    NCBI Gene ID: 57863
    neXtProt AC: NX_Q8N126
    UniProt: Q8N126

  • Chr Location
    1q23.2; chr1:159171587-159203142 (+)  GRCh38.p7
Human Diseases
more
  • Diseases
    1 with human CADM3 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    2 phenotypes from 2 alleles in 2 genetic backgrounds
    9 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele exhibit delayed myelination. Other mice with ubiquitous conditional deletion of the gene do not display neurological abnormalities.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    13
  • GO References
    5
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    882
  • Tissues
    62
  • cDNA Data
    55
  • Literature Summary
    13
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000005338 Ensembl Gene Model | MGI Sequence Detail 34437 C57BL/6J ±  kb
transcript ENSMUST00000005470 Ensembl | MGI Sequence Detail 2518 Not Applicable  
polypeptide ENSMUSP00000005470 Ensembl | MGI Sequence Detail 430 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 59
    cDNA 56
    Other 3

    Microarray probesets 6
References
more
  • Summaries
    All 48
    Developmental Gene Expression 13
    Gene Ontology 5
    Phenotypes 9
  • Earliest
    J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
  • Latest
    J:322323 Song W, et al., Putative complement control protein CSMD3 dysfunction impairs synaptogenesis and induces neurodevelopmental disorders. Brain Behav Immun. 2022 Mar 1;102:237-250
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
01/31/2023
MGI 6.22 		The Jackson Laboratory