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Hes7 Gene Detail
Summary
  • Symbol
    Hes7
  • Name
    hes family bHLH transcription factor 7
  • Synonyms
    bHLHb37
  • Feature Type
    protein coding gene
  • IDs
    MGI:2135679
    NCBI Gene: 84653
  • Alliance
    gene page
Location &
Maps
more
  • Sequence Map
    Chr11:69011230-69014881 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 11, 42.38 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    41 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2135679
 protein coding gene Chr11:69009778-69014881 (+)
129S1/SvImJ MGP_129S1SvImJ_G0018520
 protein coding gene Chr11:69525724-69529343 (+)
A/J MGP_AJ_G0018489
 protein coding gene Chr11:66911870-66915463 (+)
AKR/J MGP_AKRJ_G0018458
 protein coding gene Chr11:68915323-68918966 (+)
BALB/cJ MGP_BALBcJ_G0018460
 protein coding gene Chr11:67233411-67237034 (+)
C3H/HeJ MGP_C3HHeJ_G0018273
 protein coding gene Chr11:68931986-68935609 (+)
C57BL/6NJ MGP_C57BL6NJ_G0018912
 protein coding gene Chr11:71637613-71643141 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0016556
 protein coding gene Chr11:63851400-63854940 (+)
CAST/EiJ MGP_CASTEiJ_G0017829
 protein coding gene Chr11:69169268-69172887 (+)
CBA/J MGP_CBAJ_G0018247
 protein coding gene Chr11:74850267-74853890 (+)
DBA/2J MGP_DBA2J_G0018356
 protein coding gene Chr11:66510559-66514200 (+)
FVB/NJ MGP_FVBNJ_G0018346
 protein coding gene Chr11:66132655-66136224 (+)
LP/J MGP_LPJ_G0018427
 protein coding gene Chr11:70112711-70116330 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0018369
 protein coding gene Chr11:75474678-75478315 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0018953
 protein coding gene Chr11:69160636-69164279 (+)
PWK/PhJ MGP_PWKPhJ_G0017604
 protein coding gene Chr11:67147699-67151454 (+)
SPRET/EiJ MGP_SPRETEiJ_G0017392
 protein coding gene Chr11:68993554-68997088 (+)
WSB/EiJ MGP_WSBEiJ_G0017882
 protein coding gene Chr11:68801415-68805054 (+)



Homology
more
  • Human Ortholog
    HES7, hes family bHLH transcription factor 7
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    HES7, hes family bHLH transcription factor 7
  • Synonyms
    bHLHb37, hHes7, SCDO4
  • Links
    NCBI Gene ID: 84667
    neXtProt AC: NX_Q9BYE0
    UniProt: Q9BYE0

  • Chr Location
    17p13.1; chr17:8120592-8126634 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with Hes7 mouse models; 1 with human HES7 associations

Human Disease Mouse Models
      
IDs
 View 1 model
      
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    35 phenotypes from 9 alleles in 5 genetic backgrounds
    4 images
    21 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for a targeted null mutation exhibit disrupted somite formation leading to skeletal defects including short trunk and tail, reduced numbers of ribs, and deformed and fused vertebrae, and neonatal death. Some heterozygotes have tail kinks.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    21
  • GO References
    13
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    970
  • Tissues
    171
  • cDNA Data
    15
  • Literature Summary
    70
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000023781 Ensembl Gene Model | MGI Sequence Detail 3652 C57BL/6J ±  kb
    transcript ENSMUST00000024543 Ensembl | MGI Sequence Detail 1809 Not Applicable  
    polypeptide ENSMUSP00000024543 Ensembl | MGI Sequence Detail 225 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 29
      cDNA 16
      Primer pair 5
      Other 8

      Microarray probesets 2
    References
    more
    • Summaries
      All 107
      Developmental Gene Expression 70
      Diseases 1
      Gene Ontology 13
      Phenotypes 21
    • Earliest
      J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
    • Latest
      J:330342 Falk HJ, et al., Imaging the onset of oscillatory signaling dynamics during mouse embryo gastrulation. Development. 2022 Jul 1;149(13):dev200083
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/16/2024
    MGI 6.23     		The Jackson Laboratory