Slc1a4 MGI Mouse Gene Detail - MGI:2135601 - solute carrier family 1 (glutamate/neutral amino acid transporter), member 4

Symbol

Slc1a4
Name

solute carrier family 1 (glutamate/neutral amino acid transporter), member 4
Synonyms

ASCT1

Feature Type

protein coding gene
IDs

MGI:2135601
NCBI Gene: 55963
Alliance

gene page
Transcription Start Sites

4 TSS

Sequence Map

Chr11:20252180-20282713 bp, - strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 11, 12.97 cM
Mapping Data

3 experiments

SNPs within 2kb

521 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2135601	protein coding gene	Chr11:20252180-20282713 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0018066	protein coding gene	Chr11:17819333-17851105 (-)
A/J	MGP_AJ_G0018039	protein coding gene	Chr11:17226221-17258991 (-)
AKR/J	MGP_AKRJ_G0018003	protein coding gene	Chr11:17835357-17867216 (-)
BALB/cJ	MGP_BALBcJ_G0018007	protein coding gene	Chr11:17343992-17374083 (-)
C3H/HeJ	MGP_C3HHeJ_G0017821	protein coding gene	Chr11:17728756-17758017 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0018459	protein coding gene	Chr11:18630164-18663868 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0016117	protein coding gene	Chr11:16217542-16246773 (-)
CAST/EiJ	MGP_CASTEiJ_G0017382	protein coding gene	Chr11:17688674-17720880 (-)
CBA/J	MGP_CBAJ_G0017795	protein coding gene	Chr11:19440764-19477320 (-)
DBA/2J	MGP_DBA2J_G0017905	protein coding gene	Chr11:17173363-17200657 (-)
FVB/NJ	MGP_FVBNJ_G0017897	protein coding gene	Chr11:16913770-16943265 (-)
LP/J	MGP_LPJ_G0017976	protein coding gene	Chr11:17993137-18025540 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0017923	protein coding gene	Chr11:19892107-19923991 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0018500	protein coding gene	Chr11:17920096-17951706 (-)
PWK/PhJ	MGP_PWKPhJ_G0017162	protein coding gene	Chr11:17182700-17212263 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0016960	protein coding gene	Chr11:17642462-17675036 (-)
WSB/EiJ	MGP_WSBEiJ_G0017436	protein coding gene	Chr11:17578488-17608935 (-)

Human Ortholog

SLC1A4, solute carrier family 1 member 4

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

SLC1A4, solute carrier family 1 member 4
Synonyms

ASCT1, SATT, SPATCCM
Links

HGNC:10942

NCBI Gene ID: 6509

neXtProt AC: NX_P43007

UniProt: P43007
Chr Location

2p14; chr2:64988477-65023865 (+) GRCh38

MGI Vertebrate Homology

Slc1a4 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: SLC1A4
Gene Tree

Slc1a4

Diseases

1 with Slc1a4 mouse models

Human Disease

Mouse Models

spastic tetraplegia, thin corpus callosum, and progressive microcephaly

IDs

View 1 model

Click on a disease name to see all genes associated with that disease.

Mutations/Alleles

1 with disease annotations

References

1 with disease annotations

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Phenotype Summary

10 phenotypes from 2 alleles in 2 genetic backgrounds
14 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

10
Chemically induced (other)

1
Endonuclease-mediated

5
Targeted

4
Genomic Mutations

1 involving Slc1a4
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

39 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

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All GO Annotations

52
GO References

11

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

819
Tissues

26
cDNA Data

90
Literature Summary

7

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase slc1a4

ZFIN slc1a4

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All Sequences

50
RefSeq

4
UniProt

6
CCDS

CCDS24457.1

Ensembl

ENSMUSG00000020142 (Evidence)
NCBI Gene

55963

			Length	Strain/Species	Flank
genomic	55963	NCBI Gene Model \| MGI Sequence Detail	30534	C57BL/6J	± kb
transcript	NM_018861	RefSeq \| MGI Sequence Detail	3901	C57BL/6
polypeptide	O35874	UniProt \| EBI \| MGI Sequence Detail	532	Not Applicable

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UniProt

6 Sequences
Protein Ontology

PR:000014975 neutral amino acid transporter A

(term hierarchy)
InterPro Domains

IPR001991 Sodium:dicarboxylate symporter

IPR018107 Sodium:dicarboxylate symporter, conserved site

IPR036458 Sodium:dicarboxylate symporter superfamily

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All nucleic 93

cDNA 90

Primer pair 2

Other 1

Microarray probesets 4

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MGI:2144477

Summaries

All 55

Developmental Gene Expression 7

Diseases 1

Gene Ontology 11

Phenotypes 14
Earliest

J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
Latest

J:344184 Ratz-Mitchem ML, et al., Generation and characterization of a knock-in mouse model for spastic tetraplegia, thin corpus callosum, and progressive microcephaly (SPATCCM). Mamm Genome. 2023 Dec;34(4):572-585

TSS for Slc1a4:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr107026	Chr11:20282689-20282774 (-)	-19 bp
Tssr107025	Chr11:20282654-20282688 (-)	42 bp
Tssr107024	Chr11:20282570-20282603 (-)	126 bp
Tssr107023	Chr11:20281304-20281308 (-)	1,407 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 04/09/2024 MGI 6.23