About   Help   FAQ
Pip4k2b Gene Detail
Summary
  • Symbol
    Pip4k2b
  • Name
    phosphatidylinositol-5-phosphate 4-kinase, type II, beta
  • Synonyms
    c11, PI5P4Kbeta, Pip5k2b
  • Feature Type
    protein coding gene
  • IDs
    MGI:1934234
    NCBI Gene: 108083
  • Alliance
    genome feature page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:97605983-97635530 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 11, 61.07 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    909 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1934234
 protein coding gene Chr11:97605983-97635530 (-)
129S1/SvImJ ENSMUSG00200050143
 protein coding gene Chr11:94853096-94882646 (-)
A/J ENSMUSG00195046235
 protein coding gene Chr11:94576026-94605471 (-)
AKR/J ENSMUSG00220049992
 protein coding gene Chr11:94835173-94864613 (-)
BALB/cJ ENSMUSG00180048110
 protein coding gene Chr11:94847793-94877222 (-)
C3H/HeJ ENSMUSG00175043749
 protein coding gene Chr11:94833143-94862692 (-)
C57BL/6NJ ENSMUSG00215053493
 protein coding gene Chr11:94424004-94453554 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0017063
 protein coding gene Chr11:93494602-93525749 (-)
CAST/EiJ ENSTCUG00005050393
 protein coding gene Chr11:94286849-94316324 (-)
CBA/J ENSMUSG00210052907
 protein coding gene Chr11:94538098-94567541 (-)
DBA/2J ENSMUSG00185043067
 protein coding gene Chr11:94883051-94912590 (-)
FVB/NJ ENSMUSG00205047130
 protein coding gene Chr11:94750056-94779504 (-)
JF1/MsJ ENSUMUG00000044308
 protein coding gene Chr11:95187892-95217015 (-)
LP/J ENSMUSG00230047172
 protein coding gene Chr11:95936000-95965546 (-)
NOD/ShiLtJ ENSMUSG00190030720
 protein coding gene Chr11:94925272-94954715 (-)
NZO/HlLtJ ENSMUSG00225049348
 protein coding gene Chr11:97989360-98018803 (-)
PWK/PhJ ENSLUMG00010046489
 protein coding gene Chr11:94738011-94767357 (-)
SPRET/EiJ ENSMSPG00010048981
 protein coding gene Chr11:95235723-95263542 (-)
WSB/EiJ ENSIUOG00005042680
 protein coding gene Chr11:94688380-94717855 (-)



Homology
more
  • Human Ortholog
    PIP4K2B, phosphatidylinositol-5-phosphate 4-kinase type 2 beta
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PIP4K2B, phosphatidylinositol-5-phosphate 4-kinase type 2 beta
  • Synonyms
    PI5P4KB, PIP5K2B, PIP5KIIB, PIP5KIIbeta, PIP5P4KB
  • Links
    NCBI Gene ID: 8396
    UniProt: P78356

  • Chr Location
    17q12; chr17:38765691-38800126 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    9 phenotypes from 2 alleles in 2 genetic backgrounds
    8 phenotypes from multigenic genotypes
    19 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for disruptions in this gene are smaller than normal with less body fat and an increased sensitivity to insulin.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    48
  • GO References
    12
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    826
  • Tissues
    146
  • cDNA Data
    80
  • Literature Summary
    7
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 108083 NCBI Gene Model | MGI Sequence Detail 29548 C57BL/6J ±  kb
    transcript NM_054051 RefSeq | MGI Sequence Detail 5068 Not Specified  
    polypeptide Q80XI4 UniProt | EBI | MGI Sequence Detail 416 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      3 Sequences
    • Protein Ontology
      PR:000012742 phosphatidylinositol 5-phosphate 4-kinase type-2 beta
      (term hierarchy)
    • EC
      2.7.1.149
    • InterPro Domains
      IPR023610 Phosphatidylinositol-4/5-phosphate 5/4-kinase
      IPR002498 Phosphatidylinositol-4-phosphate 4/5-kinase, core
      IPR027483 Phosphatidylinositol-4-phosphate 4/5-kinase, C-terminal domain superfamily
      IPR027484 Phosphatidylinositol-4-phosphate 5-kinase, N-terminal
    • GlyGen
      Q80XI4 2 sites, 1 N-linked glycan (1 site), 1 O-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 81
      cDNA 80
      Other 1

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:2144293
    References
    more
    • Summaries
      All 56
      Developmental Gene Expression 7
      Gene Ontology 12
      Phenotypes 19
    • Earliest
      J:38804 Castellino AM, et al., A novel interaction between the juxtamembrane region of the p55 tumor necrosis factor receptor and phosphatidylinositol-4-phosphate 5-kinase. J Biol Chem. 1997 Feb 28;272(9):5861-70
    • Latest
      J:313619 Bedogni F, et al., Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development. Front Mol Neurosci. 2021;14:686034
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
    Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
    Send questions and comments to User Support.     		last database update
    09/01/2026
    MGI 6.24     		The Jackson Laboratory