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Scyl1 Gene Detail
Summary
  • Symbol
    Scyl1
  • Name
    SCY1-like 1 (S. cerevisiae)
  • Synonyms
    2810011O19Rik, mdf, mfd, Ntkl, p105
  • Feature Type
    protein coding gene
  • IDs
    MGI:1931787
    NCBI Gene: 78891
  • Alliance
    gene page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr19:5808450-5821461 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 19, 4.34 cM
  • Mapping Data
    6 experiments
Strain
Comparison
more
  • SNPs within 2kb
    113 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1931787
 protein coding gene Chr19:5808379-5821461 (-)
129S1/SvImJ MGP_129S1SvImJ_G0024728
 protein coding gene Chr19:2748597-2761571 (-)
A/J MGP_AJ_G0024694
 protein coding gene Chr19:2598547-2611527 (-)
AKR/J MGP_AKRJ_G0024667
 protein coding gene Chr19:2667009-2681469 (-)
BALB/cJ MGP_BALBcJ_G0024694
 protein coding gene Chr19:2593793-2606927 (-)
C3H/HeJ MGP_C3HHeJ_G0024462
 protein coding gene Chr19:2688561-2701481 (-)
C57BL/6NJ MGP_C57BL6NJ_G0025141
 protein coding gene Chr19:2815956-2830116 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0022571
 protein coding gene Chr19:2507845-2520522 (-)
CAST/EiJ MGP_CASTEiJ_G0023934
 protein coding gene Chr19:2702657-2716092 (-)
CBA/J MGP_CBAJ_G0024434
 protein coding gene Chr19:2945392-2958323 (-)
DBA/2J MGP_DBA2J_G0024561
 protein coding gene Chr19:2594185-2607139 (-)
FVB/NJ MGP_FVBNJ_G0024527
 protein coding gene Chr19:2590770-2604409 (-)
LP/J MGP_LPJ_G0024647
 protein coding gene Chr19:2720008-2734752 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0024557
 protein coding gene Chr19:2781250-2794211 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0025189
 protein coding gene Chr19:2685556-2700361 (-)
PWK/PhJ MGP_PWKPhJ_G0023680
 protein coding gene Chr19:2618148-2631484 (-)
SPRET/EiJ MGP_SPRETEiJ_G0023485
 protein coding gene Chr19:2673688-2688541 (-)
WSB/EiJ MGP_WSBEiJ_G0023996
 protein coding gene Chr19:2696396-2709278 (-)



Homology
more
  • Human Ortholog
    SCYL1, SCY1 like pseudokinase 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SCYL1, SCY1 like pseudokinase 1
  • Synonyms
    GKLP, HT019, NKTL, NTKL, P105, SCAR21, TAPK, TEIF, TRAP
  • Links
    NCBI Gene ID: 57410
    neXtProt AC: NX_Q96KG9
    UniProt: Q96KG9

  • Chr Location
    11q13.1; chr11:65525077-65538704 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with Scyl1 mouse models; 1 with human SCYL1 associations

Human Disease Mouse Models
      
IDs
 View 1 model
      
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    60 phenotypes from 4 alleles in 7 genetic backgrounds
    11 phenotypes from multigenic genotypes
    19 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a spontaneous mutation or a knock-out allele develop a motoneuron disease characterized by gait ataxia, reduced grip strength, tremors, progressive hindlimb paralysis, muscular atrophy, and motoneuron degeneration.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    28
  • GO References
    9
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    771
  • Tissues
    9
  • cDNA Data
    9
  • Literature Summary
    2
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 78891 NCBI Gene Model | MGI Sequence Detail 13012 C57BL/6J ±  kb
    transcript NR_155264 RefSeq | MGI Sequence Detail 2758 ZRU/MplStud  
    polypeptide Q9EQC5 UniProt | EBI | MGI Sequence Detail 806 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 9
      cDNA 9

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-12162, MGD-MRK-12209, MGI:1926141, MGI:2147799, MGI:96948
    References
    more
    • Summaries
      All 55
      Developmental Gene Expression 2
      Diseases 1
      Gene Ontology 9
      Phenotypes 19
    • Earliest
      J:4479 Womack JE, et al., Muscle deficient, a new mutation in the mouse. J Hered. 1980;71(1):68
    • Latest
      J:342085 Cassidy AM, et al., One-step generation of a conditional allele in mice using a short artificial intron. Heliyon. 2022;8(12):e12630
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/16/2024
    MGI 6.23     		The Jackson Laboratory