Thap11 MGI Mouse Gene Detail - MGI:1930964

Symbol

Thap11
Name

THAP domain containing 11
Synonyms

2810036E22Rik, CTG-B45d, Ronin

Feature Type

protein coding gene
IDs

MGI:1930964
NCBI Gene: 59016
Alliance

genome feature page
Transcription Start Sites

1 TSS

Sequence Map

Chr8:106581764-106583582 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 8, 53.05 cM, cytoband D2
Mapping Data

2 experiments

SNPs within 2kb

89 from dbSNP Build 142
Strain Annotations

19

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1930964	protein coding gene	Chr8:106581735-106583582 (+)
129S1/SvImJ	ENSMUSG00200013939	protein coding gene	Chr8:100861625-100863443 (+)
A/J	ENSMUSG00195016287	protein coding gene	Chr8:101184105-101185923 (+)
AKR/J	ENSMUSG00220014867	protein coding gene	Chr8:101326743-101328561 (+)
BALB/cJ	ENSMUSG00180021403	protein coding gene	Chr8:101189906-101191724 (+)
C3H/HeJ	ENSMUSG00175024884	protein coding gene	Chr8:101246618-101248436 (+)
C57BL/6NJ	ENSMUSG00215019535	protein coding gene	Chr8:100860965-100862783 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0031498	protein coding gene	Chr8:96988715-96990568 (+)
CAST/EiJ	ENSTCUG00005022449	protein coding gene	Chr8:100628123-100629941 (+)
CBA/J	ENSMUSG00210031028	protein coding gene	Chr8:101174337-101176155 (+)
DBA/2J	ENSMUSG00185005573	protein coding gene	Chr8:107283095-107284913 (+)
FVB/NJ	ENSMUSG00205013564	protein coding gene	Chr8:100158659-100160477 (+)
JF1/MsJ	ENSUMUG00000007606	protein coding gene	Chr8:109616283-109618101 (+)
LP/J	ENSMUSG00230029971	protein coding gene	Chr8:110963501-110965319 (+)
NOD/ShiLtJ	ENSMUSG00190027911	protein coding gene	Chr8:101313516-101315334 (+)
NZO/HlLtJ	ENSMUSG00225021339	protein coding gene	Chr8:114314043-114315861 (+)
PWK/PhJ	ENSLUMG00010003977	protein coding gene	Chr8:101102725-101104543 (+)
SPRET/EiJ	ENSMSPG00010035508	protein coding gene	Chr8:103175875-103177693 (+)
WSB/EiJ	ENSIUOG00005030192	protein coding gene	Chr8:101994373-101996191 (+)

Human Ortholog

THAP11, THAP domain containing 11

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

THAP11, THAP domain containing 11
Synonyms

CTG-B43a, CTG-B45d, HRIHFB2206, MAHCL, RONIN, SCA51
Links

HGNC:23194

NCBI Gene ID: 57215

UniProt: Q96EK4
Chr Location

16q22.1; chr16:67842320-67844195 (+) GRCh38

MGI Vertebrate Homology

Thap11 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: THAP11
Gene Tree

Thap11

Diseases

1 with Thap11 mouse models

Human Disease

Mouse Models

methylmalonic aciduria and homocystinuria type cblC

IDs

View 1 model

Click on a disease name to see all genes associated with that disease.

Mutations/Alleles

1 with disease annotations

References

1 with disease annotations

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Phenotype Summary

25 phenotypes from 3 alleles in 6 genetic backgrounds
8 phenotypes from multigenic genotypes
10 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

9
Endonuclease-mediated

5
Gene trapped

1
Targeted

3
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

11 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Homozygous inactivation of this gene leads to peri-implantation lethality and defects in the inner cell mass. Homozygous null ES cells are not viable.

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All GO Annotations

38
GO References

10

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

660
Tissues

21
cDNA Data

74
Literature Summary

6

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase thap11

ZFIN thap11

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All Sequences

39
RefSeq

2
UniProt

1
CCDS

CCDS22616.1

Ensembl

ENSMUSG00000036442 (Evidence)
NCBI Gene

59016

			Length	Strain/Species	Flank
genomic	ENSMUSG00000036442	Ensembl Gene Model \| MGI Sequence Detail	1819	C57BL/6J	± kb
transcript	ENSMUST00000040445	Ensembl \| MGI Sequence Detail	1819	Not Applicable
polypeptide	ENSMUSP00000048994	Ensembl \| MGI Sequence Detail	305	Not Applicable

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UniProt

1 Sequence
Protein Ontology

PR:000016304 THAP domain-containing protein 11

(term hierarchy)
InterPro Domains

IPR006612 THAP-type zinc finger

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All nucleic 77

cDNA 74

Primer pair 3

Antibodies 1

Microarray probesets 5

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MGI:1924091

Summaries

All 43

Developmental Gene Expression 6

Diseases 1

Gene Ontology 10

Phenotypes 10
Earliest

J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
Latest

J:326541 Cyagen Biosciences Inc., Cyagen Biosciences Website. 2022;

TSS for Thap11:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr79193	Chr8:106581718-106581781 (+)	-14 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 09/08/2026 MGI 6.24