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Cyp3a25 Gene Detail
Summary
  • Symbol
    Cyp3a25
  • Name
    cytochrome P450, family 3, subfamily a, polypeptide 25
  • Feature Type
    protein coding gene
  • IDs
    MGI:1930638
    NCBI Gene: 56388
  • Alliance
    genome feature page
  • Transcription Start Sites
    12 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:145914004-145946428 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 5, 85.17 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1418 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1930638
 protein coding gene Chr5:145914002-145946454 (-)
129S1/SvImJ ENSMUSG00200041248
 protein coding gene Chr5:139742706-139775322 (-)
A/J ENSMUSG00195043661
 protein coding gene Chr5:139272625-139305281 (-)
AKR/J no annotation
BALB/cJ ENSMUSG00180028081
 protein coding gene Chr5:139618038-139650696 (-)
C3H/HeJ ENSMUSG00175038437
 protein coding gene Chr5:141544846-141577498 (-)
C57BL/6NJ ENSMUSG00215040065
 protein coding gene Chr5:139415249-139447863 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0028019
 protein coding gene Chr5:138790680-138797302 (+)
CAST/EiJ ENSTCUG00005034863
 protein coding gene Chr5:138801611-138834790 (-)
CBA/J ENSMUSG00210022958
 protein coding gene Chr5:140497027-140529639 (-)
DBA/2J ENSMUSG00185039405
 protein coding gene Chr5:143347586-143380232 (-)
FVB/NJ ENSMUSG00205031639
 protein coding gene Chr5:139128747-139161361 (-)
JF1/MsJ ENSUMUG00000028595
 protein coding gene Chr5:145938681-145971401 (-)
LP/J ENSMUSG00230026146
 protein coding gene Chr5:147459695-147492313 (-)
NOD/ShiLtJ ENSMUSG00190029342
 protein coding gene Chr5:139075032-139107658 (-)
NZO/HlLtJ ENSMUSG00225008185
 protein coding gene Chr5:155075549-155108176 (-)
PWK/PhJ ENSLUMG00010017994
 protein coding gene Chr5:138242953-138276496 (-)
SPRET/EiJ ENSMSPG00010006341
 protein coding gene Chr5:141137531-141174227 (-)
WSB/EiJ ENSIUOG00005030589
 protein coding gene Chr5:141860919-141893579 (-)



Homology
more
  • Human Ortholog
    CYP3A43, cytochrome P450 family 3 subfamily A member 43
  • Vertebrate Orthologs
    7
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CYP3A43, cytochrome P450 family 3 subfamily A member 43
  • Links
    NCBI Gene ID: 64816
    UniProt: Q9HB55

  • Chr Location
    7q22.1; chr7:99827922-99867305 (+)  GRCh38
  • Human Ortholog
    CYP3A5, cytochrome P450 family 3 subfamily A member 5
  • Synonyms
    CP35, CYPIIIA5, P450PCN3, PCN3
  • Links
    NCBI Gene ID: 1577
    UniProt: P20815

  • Chr Location
    7q22.1; chr7:99648194-99679997 (-)  GRCh38
Human Diseases
more
  • Diseases
    6 with human CYP3A4,CYP3A5 associations

Human Disease Mouse Models
      
IDs
IDs
IDs
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    22 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    20
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    703
  • Tissues
    106
  • cDNA Data
    5
  • Literature Summary
    3
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000029630 Ensembl Gene Model | MGI Sequence Detail 32425 C57BL/6J ±  kb
transcript ENSMUST00000068317 Ensembl | MGI Sequence Detail 2000 Not Applicable  
polypeptide ENSMUSP00000065585 Ensembl | MGI Sequence Detail 503 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 7
    Genomic 1
    cDNA 5
    Primer pair 1

    Microarray probesets 4
Other
Accession IDs
less
MGI:2140847
References
more
  • Summaries
    All 53
    Developmental Gene Expression 3
    Gene Ontology 8
    Phenotypes 22
  • Earliest
    J:65712 Dai D, et al., Cloning, sequencing, heterologous expression, and characterization of murine cytochrome P450 3a25*(Cyp3a25), a testosterone 6beta-hydroxylase. J Biochem Mol Toxicol. 2001;15(2):90-9
  • Latest
    J:387287 Stromatt JC, et al., Drug-Drug Interaction Liabilities with BTK Inhibitor TL-895. Cancer Res Commun. 2025 Sep 1;5(9):1621-1630
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/08/2026
MGI 6.24 		The Jackson Laboratory