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Nampt Gene Detail
Summary
  • Symbol
    Nampt
  • Name
    nicotinamide phosphoribosyltransferase
  • Synonyms
    1110035O14Rik, Pbef1, Visfatin
  • Feature Type
    protein coding gene
  • IDs
    MGI:1929865
    NCBI Gene: 59027
  • Alliance
    gene page
  • Transcription Start Sites
    28 TSS
Location &
Maps
more
  • Sequence Map
    Chr12:32870334-32903368 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 12, 13.74 cM, cytoband B1
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    265 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1929865
 protein coding gene Chr12:32869544-32903368 (+)
129S1/SvImJ MGP_129S1SvImJ_G0019671
 protein coding gene Chr12:30852511-30891954 (+)
A/J MGP_AJ_G0019638
 protein coding gene Chr12:29936406-29969335 (+)
AKR/J MGP_AKRJ_G0019609
 protein coding gene Chr12:30911882-30946114 (+)
BALB/cJ MGP_BALBcJ_G0019615
 protein coding gene Chr12:30158063-30195450 (+)
C3H/HeJ MGP_C3HHeJ_G0019419
 protein coding gene Chr12:30764662-30797070 (+)
C57BL/6NJ MGP_C57BL6NJ_G0020062
 protein coding gene Chr12:31782704-31816635 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0017687
 protein coding gene Chr12:29235147-29269583 (+)
CAST/EiJ MGP_CASTEiJ_G0018974
 protein coding gene Chr12:25797008-25831189 (+)
CBA/J MGP_CBAJ_G0019391
 protein coding gene Chr12:32803193-32837400 (+)
DBA/2J MGP_DBA2J_G0019504
 protein coding gene Chr12:29764823-29798437 (+)
FVB/NJ MGP_FVBNJ_G0019495
 protein coding gene Chr12:29549328-29582843 (+)
LP/J MGP_LPJ_G0019574
 protein coding gene Chr12:30935061-30974387 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0019530
 protein coding gene Chr12:32433023-32474331 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0020102
 protein coding gene Chr12:30417464-30450529 (+)
PWK/PhJ MGP_PWKPhJ_G0018741
 protein coding gene Chr12:24524746-24557580 (+)
SPRET/EiJ MGP_SPRETEiJ_G0018529
 protein coding gene Chr12:25028277-25060704 (+)
WSB/EiJ MGP_WSBEiJ_G0019024
 protein coding gene Chr12:30657614-30692286 (+)



Homology
more
  • Human Ortholog
    NAMPT, nicotinamide phosphoribosyltransferase
  • Vertebrate Orthologs
    6
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    NAMPT, nicotinamide phosphoribosyltransferase
  • Synonyms
    1110035O14Rik, PBEF, PBEF1, VF, VISFATIN
  • Links
    NCBI Gene ID: 10135
    neXtProt AC: NX_P43490
    UniProt: P43490

  • Chr Location
    7q22.3; chr7:106248298-106285966 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with human NAMPT associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    28 phenotypes from 4 alleles in 6 genetic backgrounds
    51 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele exhibit embryonic lethality prior to E10.5. Mice heterozygous for a null allele exhibit increased fasted glucose in male mice and impaired glucose tolerance and decresed glucose-stimulated insulin secretion in female mice.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    30
  • GO References
    11
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    957
  • Tissues
    173
  • cDNA Data
    173
  • Literature Summary
    8
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 59027 NCBI Gene Model | MGI Sequence Detail 33035 C57BL/6J ±  kb
    transcript NM_021524 RefSeq | MGI Sequence Detail 4547 C57BL/6  
    polypeptide Q99KQ4 UniProt | EBI | MGI Sequence Detail 491 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 173
      cDNA 173

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:1915933, MGI:2144781, MGI:2144846
    References
    more
    • Summaries
      All 123
      Developmental Gene Expression 8
      Gene Ontology 11
      Phenotypes 51
    • Earliest
      J:93290 Araki K, et al., Exchangeable gene trap using the Cre/mutated lox system. Cell Mol Biol (Noisy-Le-Grand). 1999 Jul;45(5):737-50
    • Latest
      J:335777 Basse AL, et al., NAMPT-dependent NAD(+) biosynthesis controls circadian metabolism in a tissue-specific manner. Proc Natl Acad Sci U S A. 2023 Apr 4;120(14):e2220102120
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/16/2024
    MGI 6.23     		The Jackson Laboratory