Nampt Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Nampt
nicotinamide phosphoribosyltransferase
MGI:1929865

28 phenotypes from 4 alleles in 6 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Nampt^{Gt(RRR084)Byg}/Nampt⁺ involves: 129P2/OlaHsd * C57BL/6	decreased interleukin-6 secretion	J:194883
	decreased neutrophil cell number	J:194883
	decreased susceptibility to injury	J:194883
Nampt^{Gt(RRR084)Byg}/Nampt^{Gt(RRR084)Byg} involves: 129P2/OlaHsd * C57BL/6	preweaning lethality, complete penetrance	J:194883
Nampt^{Gt(RRT307)Byg}/Nampt⁺ B6.129P2-Nampt^{Gt(RRT307)Byg}	decreased circulating glucose level	J:130534
	decreased insulin secretion	J:130534
	impaired glucose tolerance	J:130534
Nampt^{Gt(RRT307)Byg}/Nampt^{Gt(RRT307)Byg} B6.129P2-Nampt^{Gt(RRT307)Byg}	embryonic lethality, complete penetrance	J:130534
Nampt^{tm1.1(KOMP)Vlcg}/Nampt⁺ C57BL/6N-Nampt^{tm1.1(KOMP)Vlcg}/Ucd	abnormal brain morphology	J:211773
	hydrocephaly	J:211773
Nampt^{tm1.1(KOMP)Vlcg}/Nampt^{tm1.1(KOMP)Vlcg} C57BL/6N-Nampt^{tm1.1(KOMP)Vlcg}/Ucd	embryonic lethality prior to tooth bud stage	J:211773
	preweaning lethality, complete penetrance	J:211773
Nampt^tm1Oleo/Nampt^tm1Oleo Tg(CD2-icre)4Kio/0 involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/10 * CBA/Ca	decreased B cell number	J:141448
	decreased double-negative T cell number	J:141448
	decreased T cell number	J:141448
	thymus hypoplasia	J:141448
Nampt^tm1Oleo/Nampt^tm1Oleo Tg(OPN1LW-cre)4Yzl/0 involves: 129P2/OlaHsd * FVB/N	abnormal cone electrophysiology	J:265592
	abnormal rod electrophysiology	J:265592
	retina cone cell degeneration	J:265592
	retina pigment epithelium atrophy	J:265592
Nampt^tm1Oleo/Nampt^tm1Oleo Tg(Rho-icre)1Ck/0 involves: 129P2/OlaHsd * C57BL/6 * SJL	abnormal cone electrophysiology	J:265592
	abnormal mitochondrial crista morphology	J:265592
	abnormal mitochondrial morphology	J:265592
	abnormal photoreceptor inner segment morphology	J:265592
	abnormal photoreceptor outer segment morphology	J:265592
	abnormal retina morphology	J:265592
	abnormal rod electrophysiology	J:265592
	decreased total retina thickness	J:265592
	optic nerve atrophy	J:265592
	retina photoreceptor degeneration	J:265592
	retina pigment epithelium atrophy	J:265592
	thin retina outer nuclear layer	J:265592

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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