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Anapc7 Gene Detail
Summary
  • Symbol
    Anapc7
  • Name
    anaphase promoting complex subunit 7
  • Synonyms
    APC7, prediabetic NOD sera-reactive autoantigen
  • Feature Type
    protein coding gene
  • IDs
    MGI:1929711
    NCBI Gene: 56317
  • Alliance
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:122559756-122582975 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
  • Genetic Map
    Chromosome 5, 62.36 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    727 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1929711
protein coding gene Chr5:122559646-122582978 (+)
129S1/SvImJ MGP_129S1SvImJ_G0030052
protein coding gene Chr5:126052333-126076598 (+)
A/J MGP_AJ_G0030017
protein coding gene Chr5:120831149-120853990 (+)
AKR/J MGP_AKRJ_G0029953
protein coding gene Chr5:124725509-124748677 (+)
BALB/cJ MGP_BALBcJ_G0030028
protein coding gene Chr5:122177437-122201317 (+)
C3H/HeJ MGP_C3HHeJ_G0029745
protein coding gene Chr5:125347076-125368213 (+)
C57BL/6NJ MGP_C57BL6NJ_G0030481
protein coding gene Chr5:130899541-130927660 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0027707
protein coding gene Chr5:115440664-115463837 (+)
CAST/EiJ MGP_CASTEiJ_G0029154
protein coding gene Chr5:124436897-124459426 (+)
CBA/J MGP_CBAJ_G0029715
protein coding gene Chr5:136031262-136058779 (+)
DBA/2J MGP_DBA2J_G0029865
protein coding gene Chr5:120887701-120910908 (+)
FVB/NJ MGP_FVBNJ_G0029821
protein coding gene Chr5:119878671-119902995 (+)
LP/J MGP_LPJ_G0029954
protein coding gene Chr5:126599533-126623092 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0029852
protein coding gene Chr5:139775370-139800335 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0030522
protein coding gene Chr5:124319625-124348780 (+)
PWK/PhJ MGP_PWKPhJ_G0028868
protein coding gene Chr5:119665660-119690100 (+)
SPRET/EiJ MGP_SPRETEiJ_G0028705
protein coding gene Chr5:122012497-122044253 (+)
WSB/EiJ MGP_WSBEiJ_G0029229
protein coding gene Chr5:124980540-125005531 (+)



Homology
more
  • Human Ortholog
    ANAPC7, anaphase promoting complex subunit 7
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ANAPC7, anaphase promoting complex subunit 7
  • Synonyms
    APC7, FERBON
  • Links
    NCBI Gene ID: 51434
    neXtProt AC: NX_Q9UJX3
    UniProt: Q9UJX3

  • Chr Location
    12q24.11; chr12:110372900-110403730 (-)  GRCh38

Human Diseases
more
  • Diseases
    1 with Anapc7 mouse models

Human Disease Mouse Models
      
IDs
View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    18 phenotypes from 2 alleles in 2 genetic backgrounds
    14 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele exhibit impaired swimming,difficulty moving on a pole, increased contextual freezing, and juvenile growth retardation.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000029466 Ensembl Gene Model | MGI Sequence Detail 23220 C57BL/6J ±  kb
    transcript ENSMUST00000122010 Ensembl | MGI Sequence Detail 2950 Not Applicable  
    polypeptide ENSMUSP00000113928 Ensembl | MGI Sequence Detail 565 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      3 Sequences
    • Protein Ontology
      PR:000004019 anaphase-promoting complex subunit 7
    • InterPro Domains
      IPR011990 Tetratricopeptide-like helical domain superfamily
      IPR019734 Tetratricopeptide repeat
    • GlyGen
      Q9WVM3 2 sites, 1 N-linked glycan (1 site), 1 O-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 20
      cDNA 17
      Primer pair 3

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGI:2141217
    References
    more
    • Summaries
      All 41
      Developmental Gene Expression 3
      Diseases 1
      Gene Ontology 5
      Phenotypes 14
    • Earliest
      J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    last database update
    11/19/2024
    MGI 6.24
    The Jackson Laboratory