Anapc7^tm1.1Azbi
Targeted Allele Detail

Summary

• Symbol: Anapc7^tm1.1Azbi
• Name: anaphase promoting complex subunit 7; targeted mutation 1.1, Azad Bonni
• MGI ID: MGI:6887761
• Gene: Anapc7 Location: Chr5:122559756-122582975 bp, + strand Genetic Position: Chr5, 62.36 cM
• Alliance: Anapc7^tm1.1Azbi page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:320745
• Parent Cell Line: EDJ22 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Not Applicable)
• Mutations: Insertion, Intragenic deletion, Single point mutation
• Mutation details: The targeting construct deleted exons 4 through 6 and inserted a G to A point mutation in exon 7 that results in a premature stop codon and a floxed neomycin resistance cassette downstream of exon 7. Cre-mediated recombination removed the selection cassette. (J:320745)

Disease models

Expression

In Mice Carrying this Mutation:

62 assay results

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Anapc7 Mutation: 24 strains or lines available

References

• Original: J:320745 Ferguson CJ, et al., APC7 mediates ubiquitin signaling in constitutive heterochromatin in the developing mammalian brain. Mol Cell. 2022 Jan 6;82(1):90-105.e13
• All: 2 reference(s)