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Cyp2d22 Gene Detail
Summary
  • Symbol
    Cyp2d22
  • Name
    cytochrome P450, family 2, subfamily d, polypeptide 22
  • Synonyms
    2D22
  • Feature Type
    protein coding gene
  • IDs
    MGI:1929474
    NCBI Gene: 56448
  • Member of
    Cyp2d cluster
  • Alliance
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr15:82254728-82264461 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
  • Genetic Map
    Chromosome 15, 38.57 cM, cytoband E2
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    66 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1929474
protein coding gene Chr15:82254728-82264461 (-)
129S1/SvImJ MGP_129S1SvImJ_G0022146
protein coding gene Chr15:82879889-82889609 (-)
A/J MGP_AJ_G0022106
protein coding gene Chr15:79941059-79951389 (-)
AKR/J MGP_AKRJ_G0022082
protein coding gene Chr15:82161307-82171011 (-)
BALB/cJ MGP_BALBcJ_G0022112
protein coding gene Chr15:79992080-80001811 (-)
C3H/HeJ MGP_C3HHeJ_G0021883
protein coding gene Chr15:82186643-82196261 (-)
C57BL/6NJ MGP_C57BL6NJ_G0022555
protein coding gene Chr15:86126413-86136216 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0020084
protein coding gene Chr15:76373493-76381739 (-)
CAST/EiJ MGP_CASTEiJ_G0021403
protein coding gene Chr15:82974302-82984026 (-)
CBA/J MGP_CBAJ_G0021848
protein coding gene Chr15:88836125-88845915 (-)
DBA/2J MGP_DBA2J_G0021976
protein coding gene Chr15:79411453-79421134 (-)
FVB/NJ MGP_FVBNJ_G0021953
protein coding gene Chr15:78479337-78489375 (-)
LP/J MGP_LPJ_G0022045
protein coding gene Chr15:83034689-83044425 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0021974
protein coding gene Chr15:93715578-93725369 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0022569
protein coding gene Chr15:82272990-82282793 (-)
PWK/PhJ MGP_PWKPhJ_G0021145
protein coding gene Chr15:79468400-79478277 (-)
SPRET/EiJ MGP_SPRETEiJ_G0020984
protein coding gene Chr15:82049174-82058915 (-)
WSB/EiJ MGP_WSBEiJ_G0021454
protein coding gene Chr15:82703000-82712781 (-)



Homology
more
  • Human Ortholog
    CYP2D6, cytochrome P450 family 2 subfamily D member 6
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CYP2D6, cytochrome P450 family 2 subfamily D member 6
  • Synonyms
    CPD6, CYP2D, CYP2D7AP, CYP2D7BP, CYP2D7P2, CYP2D8P2, CYP2DL1, CYPIID6, P450C2D, P450DB1, P450-DB1
  • Links
    NCBI Gene ID: 1565
    neXtProt AC: NX_P10635
    UniProt: P10635

  • Chr Location
    22q13.2; chr22:42126499-42130865 (-)  GRCh38

  • Human Ortholog
    CYP2D7, cytochrome P450 family 2 subfamily D member 7 (gene/pseudogene)
  • Synonyms
    CYP2D, CYP2D@, CYP2D6, CYP2D7AP, CYP2D7P, CYP2D7P1, P450C2D, P450DB1, RNA40057
  • Links
    NCBI Gene ID: 1564
    neXtProt AC: NX_A0A087X1C5
    UniProt: A0A087X1C5

  • Chr Location
    22q13.2; chr22:42139576-42149455 (-)  GRCh38

Human Diseases
more
  • Diseases
    9 with human CYP2D6 associations

Human Disease Mouse Models
      
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    3 phenotypes from 1 allele in 1 genetic background
    29 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 56448 NCBI Gene Model | MGI Sequence Detail 9734 C57BL/6J ±  kb
    transcript NM_001163472 RefSeq | MGI Sequence Detail 2788 C57BL/6  
    polypeptide NP_062797 RefSeq | MGI Sequence Detail 500 C57BL/6  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 100
      cDNA 98
      Primer pair 2

      Microarray probesets 4
    References
    more
    • Summaries
      All 49
      Developmental Gene Expression 2
      Diseases 1
      Gene Ontology 4
      Phenotypes 29
    • Earliest
      J:7688 Lane PW, et al., Association of megacolon with a new dominant spotting gene (Dom) in the mouse. J Hered. 1984 Nov-Dec;75(6):435-9
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    last database update
    07/02/2024
    MGI 6.13
    The Jackson Laboratory