Shoc2 MGI Mouse Gene Detail - MGI:1927197 - Shoc2, leucine rich repeat scaffold protein

About Help FAQ

Shoc2 Gene Detail

Symbol

Shoc2
Name

Shoc2, leucine rich repeat scaffold protein
Synonyms

mKIAA0862, soc-2 (suppressor of clear) homolog (C. elegans), Sur-8

Feature Type

protein coding gene
IDs

MGI:1927197
NCBI Gene: 56392
Alliance

genome feature page
Transcription Start Sites

7 TSS
Candidate for QTL

1 QTL

more

Sequence Map

Chr19:53932737-54021564 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 19, 48.83 cM
Mapping Data

3 experiments

more

SNPs within 2kb

1742 from dbSNP Build 142
Strain Annotations

19

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates	Select Strains
C57BL/6J	MGI_C57BL6J_1927197	protein coding gene	Chr19:53932018-54021711 (+)
129S1/SvImJ	ENSMUSG00200014081	protein coding gene	Chr19:50628814-50717668 (+)
A/J	ENSMUSG00195002544	protein coding gene	Chr19:50803533-50892422 (+)
AKR/J	ENSMUSG00220017564	protein coding gene	Chr19:50573427-50662300 (+)
BALB/cJ	ENSMUSG00180017415	protein coding gene	Chr19:51043179-51132081 (+)
C3H/HeJ	ENSMUSG00175021508	protein coding gene	Chr19:50578874-50667748 (+)
C57BL/6NJ	ENSMUSG00215015961	protein coding gene	Chr19:50667342-50756193 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0023078	protein coding gene	Chr19:50449239-50534185 (+)
CAST/EiJ	ENSTCUG00005016521	protein coding gene	Chr19:50232134-50318427 (+)
CBA/J	ENSMUSG00210021039	protein coding gene	Chr19:50658367-50747237 (+)
DBA/2J	ENSMUSG00185027879	protein coding gene	Chr19:51156830-51245704 (+)
FVB/NJ	ENSMUSG00205018311	protein coding gene	Chr19:50042122-50130998 (+)
JF1/MsJ	ENSUMUG00000036638	protein coding gene	Chr19:51348162-51433368 (+)
LP/J	ENSMUSG00230026070	protein coding gene	Chr19:51910468-51999322 (+)
NOD/ShiLtJ	ENSMUSG00190012874	protein coding gene	Chr19:50525512-50614377 (+)
NZO/HlLtJ	ENSMUSG00225024806	protein coding gene	Chr19:55512770-55601634 (+)
PWK/PhJ	ENSLUMG00010017963	protein coding gene	Chr19:50397059-50485989 (+)
SPRET/EiJ	ENSMSPG00010006722	protein coding gene	Chr19:50282991-50328089 (+)
WSB/EiJ	ENSIUOG00005005701	protein coding gene	Chr19:50023976-50112824 (+)

more

Human Ortholog

SHOC2, SHOC2 leucine rich repeat scaffold protein

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

SHOC2, SHOC2 leucine rich repeat scaffold protein
Synonyms

NSLH1, SIAA0862, SOC2, SUR8
Links

HGNC:15454

NCBI Gene ID: 8036

UniProt: Q9UQ13
Chr Location

10q25.2; chr10:110917932-111017307 (+) GRCh38

MGI Vertebrate Homology

Shoc2 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: SHOC2
Gene Tree

Shoc2

more

Diseases

2 with human SHOC2 associations

				Human Disease	Mouse Models
				atopic dermatitis IDs atopic dermatitis DOID:3310 EFO:0000274 ICD10CM:L20 MESH:D003876 NCI:C211594 OMIM:603165 OMIM:PS603165 UMLS_CUI:C0011615
				Noonan syndrome-like disorder with loose anagen hair 1 IDs Noonan syndrome-like disorder with loose anagen hair 1 DOID:0080692 OMIM:607721

Click on a disease name to see all genes associated with that disease.

less

Phenotype Summary

19 phenotypes from 2 alleles in 3 genetic backgrounds
11 phenotype references

Phenotype Overview

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

31
Endonuclease-mediated

1
Gene trapped

26
Targeted

4
Find Mice (IMSR)

46 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Shoc2 is essential for embryonic development, as germline deletion results in early embryonic lethality. Endothelial cell-specific deletion causes defects in cardiac development, and results in late embryonic/early fetal lethality.

less

All GO Annotations

44
GO References

7

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

less

Expression Overview

Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

628
Tissues

7
cDNA Data

106
Literature Summary

3

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase shoc2

ZFIN shoc2

less

All Sequences

63
RefSeq

14
UniProt

4
CCDS

CCDS29904.1

Ensembl

ENSMUSG00000024976 (Evidence)
NCBI Gene

56392

Representative Sequences				Length	Strain/Species	Flank
	genomic	ENSMUSG00000024976	Ensembl Gene Model \| MGI Sequence Detail	88828	C57BL/6J	± kb
	transcript	ENSMUST00000025932	Ensembl \| MGI Sequence Detail	3965	Not Applicable
	polypeptide	ENSMUSP00000025932	Ensembl \| MGI Sequence Detail	582	Not Applicable

less

UniProt

4 Sequences
Protein Ontology

PR:000032078 leucine-rich repeat protein SHOC-2

(term hierarchy)
InterPro Domains

IPR055414 Disease resistance R13L4/SHOC-2-like, LRR domain

IPR001611 Leucine-rich repeat

IPR050216 Leucine-rich repeat domain-containing protein

IPR032675 Leucine-rich repeat domain superfamily

IPR003591 Leucine-rich repeat, typical subtype

less

All nucleic 106

cDNA 106

Microarray probesets 5

less

MGI:2147642

more

Summaries

All 45

Developmental Gene Expression 3

Gene Ontology 7

Phenotypes 11
Earliest

J:48584 Sieburth DS, et al., SUR-8, a conserved Ras-binding protein with leucine-rich repeats, positively regulates Ras-mediated signaling in C. elegans. Cell. 1998 Jul 10;94(1):119-30
Latest

J:378488 You X, et al., SHOC2 plays an oncogenic or tumor-suppressive role by differentially targeting the MAPK and mTORC1 signals in liver cancer. Life Med. 2024 Jun;3(3):lnae023

TSS for Shoc2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr157049	Chr19:53932494-53932527 (+)	-226 bp
Tssr157050	Chr19:53933271-53933298 (+)	548 bp
Tssr157051	Chr19:53933301-53933338 (+)	583 bp
Tssr157052	Chr19:53934347-53934349 (+)	1,611 bp
Tssr157053	Chr19:53938466-53938483 (+)	5,738 bp
Tssr157054	Chr19:53938821-53938866 (+)	6,107 bp
Tssr157055	Chr19:54008812-54008817 (+)	76,078 bp

Shoc2 is Candidate Gene for:

QTL	Genetic Location*	Genome Location (GRCm39)	Reference	QTL Note
Alcdp2	Chr19, syntenic		J:98587	Microarray analysis was used to identify genes showing alcohol-induced differential expression between inbred strains C57BL/6J and DBA/2J. These genes were then correlated to 6 previously identified alcohol-related QTLs to identify potential candidate genes. Two different Affymetrix microarrays were used in the analysis. Brain expression data from parental strains and 56 (DBA/2J x C57BL/6J)F2 intercross animals were used for analysis. On mouse Chromosome 19, candidate genes for Alcdp2 at 40 cM were identified with modest priority status. These candidate genes are Scd1 (43 cM), Shoc2, Prdx3 (50 cM), and 3 other yet unidentified expressed sequences (ESTs).

*cM position of peak correlated region/marker

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 09/01/2026 MGI 6.24