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Lat2 Gene Detail
Summary
  • Symbol
    Lat2
  • Name
    linker for activation of T cells family, member 2
  • Synonyms
    Wbscr15, Wbscr5
  • Feature Type
    protein coding gene
  • IDs
    MGI:1926479
    NCBI Gene: 56743
  • Alliance
    genome feature page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:134628876-134643879 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 5, 74.70 cM
  • Mapping Data
    5 experiments
Strain
Comparison
more
  • SNPs within 2kb
    552 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1926479
 protein coding gene Chr5:134628876-134648637 (-)
129S1/SvImJ ENSMUSG00200043653
 protein coding gene Chr5:128410365-128425375 (-)
A/J ENSMUSG00195050359
 protein coding gene Chr5:127917171-127932153 (-)
AKR/J ENSMUSG00220048807
 protein coding gene Chr5:127402136-127417116 (-)
BALB/cJ ENSMUSG00180041150
 protein coding gene Chr5:128021120-128036122 (-)
C3H/HeJ ENSMUSG00175039139
 protein coding gene Chr5:129947783-129962790 (-)
C57BL/6NJ ENSMUSG00215045278
 protein coding gene Chr5:128066690-128081692 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0027815
 protein coding gene Chr5:127399560-127414175 (-)
CAST/EiJ ENSTCUG00005009318
 protein coding gene Chr5:127289869-127304907 (-)
CBA/J ENSMUSG00210007192
 protein coding gene Chr5:128765476-128780482 (-)
DBA/2J ENSMUSG00185049259
 protein coding gene Chr5:131780638-131795646 (-)
FVB/NJ ENSMUSG00205035385
 protein coding gene Chr5:127669877-127684861 (-)
JF1/MsJ ENSUMUG00000038834
 protein coding gene Chr5:134675730-134691157 (-)
LP/J ENSMUSG00230043458
 protein coding gene Chr5:135895337-135910341 (-)
NOD/ShiLtJ ENSMUSG00190045409
 protein coding gene Chr5:127722111-127737116 (-)
NZO/HlLtJ ENSMUSG00225021934
 protein coding gene Chr5:143576020-143591033 (-)
PWK/PhJ ENSLUMG00010018101
 protein coding gene Chr5:126519659-126534697 (-)
SPRET/EiJ ENSMSPG00010030083
 protein coding gene Chr5:129938518-129950890 (-)
WSB/EiJ ENSIUOG00005033582
 protein coding gene Chr5:130366665-130381645 (-)



Homology
more
  • Human Ortholog
    LAT2, linker for activation of T cells family member 2
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    LAT2, linker for activation of T cells family member 2
  • Synonyms
    HSPC046, LAB, NTAL, WBSCR15, WBSCR5, WSCR5
  • Links
    NCBI Gene ID: 7462
    UniProt: Q9GZY6

  • Chr Location
    7q11.23; chr7:74199652-74234454 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with human LAT2 associations

Human Disease Mouse Models
      
IDs
 View 2 models
Click on a disease name to see all genes associated with that disease.

  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    22 phenotypes from 4 alleles in 6 genetic backgrounds
    7 phenotypes from multigenic genotypes
    35 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele have abnormal mast cell physiology and increased anti-nuclear antigen antibody level. Mice homozygous for another null allele show abnormal mast cell physiology, hyperactivated T cells, higher cytokine production, spleenhyperplasia and increased autoantibody level.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    27
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    609
  • Tissues
    12
  • cDNA Data
    30
  • Literature Summary
    1
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000040751 Ensembl Gene Model | MGI Sequence Detail 15004 C57BL/6J ±  kb
    transcript ENSMUST00000036362 Ensembl | MGI Sequence Detail 1637 Not Applicable  
    polypeptide ENSMUSP00000046900 Ensembl | MGI Sequence Detail 203 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      4 Sequences
    • Protein Ontology
      PR:000009684 linker for activation of T-cells family member 2
      (term hierarchy)
    • InterPro Domains
      IPR031428 Linker for activation of T-cells family member 2
    Molecular
    Reagents
    less
    • All nucleic 33
      Genomic 2
      cDNA 30
      Primer pair 1

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:1890416, MGI:2141162
    References
    more
    • Summaries
      All 73
      Developmental Gene Expression 1
      Diseases 2
      Gene Ontology 7
      Phenotypes 35
    • Earliest
      J:64707 Martindale DW, et al., Comparative genomic sequence analysis of the williams syndrome region (LIMK1-RFC2) of human chromosome 7q11.23. Mamm Genome. 2000 Oct;11(10):890-8
    • Latest
      J:373971 Gutzen R, et al., A modular and adaptable analysis pipeline to compare slow cerebral rhythms across heterogeneous datasets. Cell Rep Methods. 2024 Jan 22;4(1):100681
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory