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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Lat2
linker for activation of T cells family, member 2
MGI:1926479
22 phenotypes from 4 alleles in 6 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Lat2tm1Mal/Lat2tm1Mal
B6.129S2-Lat2tm1Mal 		increased anti-nuclear antigen antibody level J:126321
Lat2tm1Mal/Lat2tm1Mal
involves: 129S2/SvPas 		abnormal mast cell physiology J:93950
Lat2tm1Wz/Lat2tm1Wz
B6.Cg-Lat2tm1Wz 		abnormal CD8-positive, alpha-beta T cell physiology J:116157
abnormal cytokine secretion J:116157
abnormal T cell physiology J:116157
increased anti-double stranded DNA antibody level J:116157
increased autoantibody level J:116157
increased T cell proliferation J:116157
spleen hyperplasia J:116157
Lat2tm1Wz/Lat2tm1Wz
involves: C57BL/6 		abnormal mast cell physiology J:93951
Lat2tm1Wz/Lat2tm1Wz
Not Specified 		abnormal T cell physiology J:181866
decreased interleukin-12 secretion J:181866
increased circulating interleukin-6 level J:181866
increased circulating tumor necrosis factor level J:181866
increased interferon-gamma secretion J:181866
increased interleukin-10 secretion J:181866
increased mast cell degranulation J:181866
increased susceptibility to endotoxin shock J:181866
increased susceptibility to xenobiotic induced morbidity/mortality J:181866
Lat2tm2Wz/Lat2tm2Wz
Tg(Lck-cre)548Jxm/0
involves: C57BL/6 		abnormal CD4-positive, alpha-beta T cell physiology J:116157
enlarged spleen J:116157
increased activated T cell number J:116157
increased anti-double stranded DNA antibody level J:116157
Lat2tm3.1Wz/Lat2tm3.1Wz
B6.Cg-Lat2tm3.1Wz 		abnormal T cell physiology J:181866
enlarged spleen J:181866
normal immune system phenotype J:181866
increased interferon-gamma secretion J:181866
increased mast cell degranulation J:181866
increased memory T cell number J:181866
increased susceptibility to endotoxin shock J:181866
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/30/2024
MGI 6.23 		The Jackson Laboratory