Lat2^tm1Wz
Targeted Allele Detail

Summary

• Symbol: Lat2^tm1Wz
• Name: linker for activation of T cells family, member 2; targeted mutation 1, Weiguo Zhang
• MGI ID: MGI:3510962
• Synonyms: LAB^-, NLAT^KO
• Gene: Lat2 Location: Chr5:134628876-134643879 bp, - strand Genetic Position: Chr5, 74.7 cM
• Alliance: Lat2^tm1Wz page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:93951
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exons 2-8 were replaced with a neomycin resistance gene. The deleted region encoded the 5' terminal from residues 1-113, including the transmembrane domain and palmitoylation site. Immunoprecipitation of protein from splenocyte and mast cell lysates followed by immunoblot confirmed the absence of protein in mutants. (J:93951)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Lat2 Mutation: 17 strains or lines available

References

• Original: J:93951 Zhu M, et al., Positive and negative regulation of FcepsilonRI-mediated signaling by the adaptor protein LAB/NTAL. J Exp Med. 2004 Oct 18;200(8):991-1000
• All: 9 reference(s)