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Notum Gene Detail
Summary
  • Symbol
    Notum
  • Name
    notum palmitoleoyl-protein carboxylesterase
  • Synonyms
    5730593N15Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1924833
    NCBI Gene: 77583
  • Alliance
    gene page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:120544614-120552001 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 11, 84.38 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    166 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1924833
 protein coding gene Chr11:120544614-120552019 (-)
129S1/SvImJ MGP_129S1SvImJ_G0019520
 protein coding gene Chr11:125134725-125142118 (-)
A/J MGP_AJ_G0019488
 protein coding gene Chr11:119563734-119571121 (-)
AKR/J MGP_AKRJ_G0019458
 protein coding gene Chr11:123177853-123185252 (-)
BALB/cJ MGP_BALBcJ_G0019463
 protein coding gene Chr11:119923134-119930541 (-)
C3H/HeJ MGP_C3HHeJ_G0019269
 protein coding gene Chr11:123496518-123503905 (-)
C57BL/6NJ MGP_C57BL6NJ_G0019911
 protein coding gene Chr11:128921390-128928801 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0017537
 protein coding gene Chr11:116553770-116561134 (-)
CAST/EiJ MGP_CASTEiJ_G0018823
 protein coding gene Chr11:125004242-125011601 (-)
CBA/J MGP_CBAJ_G0019240
 protein coding gene Chr11:133955407-133962818 (-)
DBA/2J MGP_DBA2J_G0019352
 protein coding gene Chr11:118932067-118939448 (-)
FVB/NJ MGP_FVBNJ_G0019344
 protein coding gene Chr11:118645955-118653342 (-)
LP/J MGP_LPJ_G0019424
 protein coding gene Chr11:125435411-125442804 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0019377
 protein coding gene Chr11:132794539-132801914 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0019951
 protein coding gene Chr11:123848032-123855415 (-)
PWK/PhJ MGP_PWKPhJ_G0018589
 protein coding gene Chr11:120373259-120380726 (-)
SPRET/EiJ MGP_SPRETEiJ_G0018381
 protein coding gene Chr11:123614551-123621836 (-)
WSB/EiJ MGP_WSBEiJ_G0018875
 protein coding gene Chr11:123840737-123848149 (-)



Homology
more
  • Human Ortholog
    NOTUM, notum, palmitoleoyl-protein carboxylesterase
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    NOTUM, notum, palmitoleoyl-protein carboxylesterase
  • Synonyms
    hNOTUM
  • Links
    NCBI Gene ID: 147111
    UniProt: Q6P988

  • Chr Location
    17q25.3; chr17:81952507-81961840 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    46 phenotypes from 3 alleles in 3 genetic backgrounds
    20 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null mutation display perinatal lethality, abnormal kidney development, and impaired tracheal cartilage development. Mice homozygous for a gene trapped allele exhibit abnormal dentin development, periodontal inflammation, tooth decay and increased bone mineral density.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    14
  • GO References
    3
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

No experimental evidence to support Cellular Component annotation, following literature review. See J:73796.
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    811
  • Tissues
    40
  • cDNA Data
    7
  • Literature Summary
    16
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000042988 Ensembl Gene Model | MGI Sequence Detail 7388 C57BL/6J ±  kb
    transcript ENSMUST00000106177 Ensembl | MGI Sequence Detail 2212 Not Applicable  
    polypeptide ENSMUSP00000101783 Ensembl | MGI Sequence Detail 503 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 12
      cDNA 7
      Primer pair 2
      Other 3

      Microarray probesets 3
    References
    more
    • Summaries
      All 56
      Developmental Gene Expression 16
      Gene Ontology 3
      Phenotypes 20
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:365296 Bottasso-Arias N, et al., Wnt5a and Notum influence the temporal dynamics of cartilaginous mesenchymal condensations in developing trachea. Front Cell Dev Biol. 2025;13:1523833
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    03/25/2025
    MGI 6.24     		The Jackson Laboratory