Coq6 MGI Mouse Gene Detail - MGI:1924408 - coenzyme Q6 monooxygenase

Symbol

Coq6
Name

coenzyme Q6 monooxygenase
Synonyms

5930427M12Rik

Feature Type

protein coding gene
IDs

MGI:1924408
NCBI Gene: 217707
Alliance

gene page
Transcription Start Sites

3 TSS

Sequence Map

Chr12:84408530-84420570 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 12, 39.18 cM
Mapping Data

1 experiment

SNPs within 2kb

59 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1924408	protein coding gene	Chr12:84408431-84420570 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0019934	protein coding gene	Chr12:85065298-85077432 (+)
A/J	MGP_AJ_G0019891	protein coding gene	Chr12:81845340-81857531 (+)
AKR/J	MGP_AKRJ_G0019867	protein coding gene	Chr12:84063703-84075640 (+)
BALB/cJ	MGP_BALBcJ_G0019871	protein coding gene	Chr12:82179003-82191016 (+)
C3H/HeJ	MGP_C3HHeJ_G0019677	protein coding gene	Chr12:84527099-84538903 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0020322	protein coding gene	Chr12:87510371-87522815 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0017940	protein coding gene	Chr12:78747958-78759824 (+)
CAST/EiJ	MGP_CASTEiJ_G0019226	protein coding gene	Chr12:79480152-79492026 (+)
CBA/J	MGP_CBAJ_G0019648	protein coding gene	Chr12:90891745-90903823 (+)
DBA/2J	MGP_DBA2J_G0019763	protein coding gene	Chr12:81374438-81386582 (+)
FVB/NJ	MGP_FVBNJ_G0019749	protein coding gene	Chr12:80326045-80338062 (+)
LP/J	MGP_LPJ_G0019835	protein coding gene	Chr12:84943469-84955602 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0019788	protein coding gene	Chr12:93802892-93818756 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0020356	protein coding gene	Chr12:83657398-83669503 (+)
PWK/PhJ	MGP_PWKPhJ_G0018990	protein coding gene	Chr12:75861987-75874274 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0018785	protein coding gene	Chr12:78146153-78158185 (+)
WSB/EiJ	MGP_WSBEiJ_G0019278	protein coding gene	Chr12:84368624-84382065 (+)

Human Ortholog

COQ6, coenzyme Q6, monooxygenase

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

COQ6, coenzyme Q6, monooxygenase
Synonyms

CGI10, CGI-10, COQ10D6
Links

HGNC:20233

NCBI Gene ID: 51004

neXtProt AC: NX_Q9Y2Z9

UniProt: Q9Y2Z9
Chr Location

14q24.3; chr14:73949926-73963670 (+) GRCh38

MGI Vertebrate Homology

Coq6 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: COQ6
Gene Tree

Coq6

Diseases

1 with human COQ6 associations

				Human Disease	Mouse Models
				primary coenzyme Q10 deficiency 6 IDs primary coenzyme Q10 deficiency 6 DOID:0070243 OMIM:614650 ORDO:280406

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

35 phenotypes from 3 alleles in 4 genetic backgrounds
9 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

7
Chemically induced (other)

1
Gene trapped

2
Targeted

4
Genomic Mutations

1 involving Coq6
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

29 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a knock-out allele are embryonic lethal.

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All GO Annotations

23
GO References

12

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

809
Tissues

99
cDNA Data

55
Literature Summary

3

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase coq6

ZFIN coq6

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All Sequences

64
RefSeq

7
UniProt

4
CCDS

CCDS26044.1

Ensembl

ENSMUSG00000021235 (Evidence)
NCBI Gene

217707

			Length	Strain/Species	Flank
genomic	217707	NCBI Gene Model \| MGI Sequence Detail	12041	C57BL/6J	± kb
transcript	NM_172582	RefSeq \| MGI Sequence Detail	1602	Not Specified
polypeptide	Q8R1S0	UniProt \| EBI \| MGI Sequence Detail	476	Not Applicable

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UniProt

4 Sequences
Protein Ontology

PR:000005755 ubiquinone biosynthesis monooxygenase COQ6, mitochondrial

(term hierarchy)
EC

1.14.13.-
InterPro Domains

IPR002938 FAD-binding domain

IPR036188 FAD/NAD(P)-binding domain superfamily

IPR010971 Ubiquinone biosynthesis hydroxylase UbiH/COQ6

IPR018168 Ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6, conserved site

IPR000689 Ubiquinone biosynthesis monooxygenase COQ6

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All nucleic 56

cDNA 55

Primer pair 1

Microarray probesets 6

Summaries

All 44

Developmental Gene Expression 3

Gene Ontology 12

Phenotypes 9
Earliest

J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
Latest

J:305946 Xu M, et al., The SRCAP chromatin remodeling complex promotes oxidative metabolism during prenatal heart development. Development. 2021 Apr 15;148(8):dev199026

TSS for Coq6:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr114338	Chr12:84408410-84408417 (+)	-116 bp
Tssr114339	Chr12:84408775-84408792 (+)	254 bp
Tssr114340	Chr12:84408803-84408830 (+)	287 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 04/16/2024 MGI 6.23