Tmem181a MGI Mouse Gene Detail - MGI:1924356

Symbol

Tmem181a
Name

transmembrane protein 181A
Synonyms

5930418K15Rik, C76977, Gpr178, mKIAA1423, Tmem181

Feature Type

protein coding gene
IDs

MGI:1924356
NCBI Gene: 77106
Alliance

gene page
Transcription Start Sites

5 TSS

Sequence Map

Chr17:6307135-6358589 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 17, 3.85 cM
Mapping Data

4 experiments

SNPs within 2kb

72 from dbSNP Build 142
Strain Annotations

8

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1924356	protein coding gene	Chr17:6307001-6358589 (+)
129S1/SvImJ	no annotation
A/J	no annotation
AKR/J	no annotation
BALB/cJ	no annotation
C3H/HeJ	MGP_C3HHeJ_G0022845	protein coding gene	Chr17:3512470-3579062 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0023530	protein coding gene	Chr17:3646820-3653580 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0021030	protein coding gene	Chr17:3139384-3177528 (+)
CAST/EiJ	no annotation
CBA/J	no annotation
DBA/2J	no annotation
FVB/NJ	MGP_FVBNJ_G0022924	protein coding gene	Chr17:3597377-3617073 (-)
LP/J	no annotation
NOD/ShiLtJ	no annotation
NZO/HlLtJ	MGP_NZOHlLtJ_G0023550	protein coding gene	Chr17:3691015-3723816 (-)
PWK/PhJ	MGP_PWKPhJ_G0022109	protein coding gene	Chr17:3546707-3590941 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0021935	protein coding gene	Chr17:3407102-3450898 (+)
WSB/EiJ	no annotation

Human Ortholog

TMEM181, transmembrane protein 181

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

TMEM181, transmembrane protein 181
Synonyms

GPR178, KIAA1423
Links

HGNC:20958

NCBI Gene ID: 57583

neXtProt AC: NX_Q9P2C4

UniProt: Q9P2C4
Chr Location

6q25.3; chr6:158536436-158635429 (+) GRCh38

Alliance of Genome Resources

Tmem181a stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: TMEM181
Gene Tree

Tmem181a

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References

6 with disease annotations

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Phenotype Summary

1 phenotype from 1 allele in 1 genetic background
330 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	immune system	integument	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	neoplasm	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	vision/eye

Click cells to view annotations.

All Mutations and Alleles

3
Radiation induced

1
Targeted

2
Genomic Mutations

1 involving Tmem181a
Find Mice (IMSR)

35 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

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All GO Annotations

2
GO References

2

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

731
Tissues

18
cDNA Data

7
Literature Summary

2

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase tmem181

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Tmem181a interacts with 61 markers (Mir7-1, Mir15a, Mir30a, ...) View All

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All Sequences

49
RefSeq

12
UniProt

2
CCDS

CCDS37425.1, CCDS88983.1

Ensembl

ENSMUSG00000038141 (Evidence)
NCBI Gene

77106

			Length	Strain/Species	Flank
genomic	ENSMUSG00000038141	Ensembl Gene Model \| MGI Sequence Detail	51455	C57BL/6J	± kb
transcript	ENSMUST00000232383	Ensembl \| MGI Sequence Detail	4499	Not Applicable
polypeptide	ENSMUSP00000156382	Ensembl \| MGI Sequence Detail	515	Not Applicable

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UniProt

2 Sequences
InterPro Domains

IPR040416 Transmembrane protein 181

IPR047843 Wntless-like, transmembrane domain

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All nucleic 7

cDNA 7

Microarray probesets 1

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MGI:2147116

Summaries

All 353

Developmental Gene Expression 2

Diseases 6

Gene Ontology 2

Phenotypes 330
Earliest

J:30229 Davisson MT, et al., Segmental trisomy as a mouse model for Down syndrome. Prog Clin Biol Res. 1993;384:117-33
Latest

J:342378 Gautier MK, et al., Maternal choline supplementation protects against age-associated cholinergic and GABAergic basal forebrain neuron degeneration in the Ts65Dn mouse model of Down syndrome and Alzheimer's disease. Neurobiol Dis. 2023 Oct 26;188:106332

TSS for Tmem181a:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr142470	Chr17:6307112-6307133 (+)	-12 bp
Tssr142471	Chr17:6307165-6307213 (+)	54 bp
Tssr142472	Chr17:6320731-6320783 (+)	13,622 bp
Tssr4991	Chr17:6347004-6347007 (+)	39,871 bp
Tssr4992	Chr17:6358268-6358271 (+)	51,135 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/28/2023 MGI 6.22