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Rftn1 Gene Detail
Summary
  • Symbol
    Rftn1
  • Name
    raftlin lipid raft linker 1
  • Synonyms
    2310015N21Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1923688
    NCBI Gene: 76438
  • Alliance
  • Transcription Start Sites
    24 TSS
Location &
Maps
more
  • Sequence Map
    Chr17:50300287-50497525 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
  • Genetic Map
    Chromosome 17, 25.86 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    5591 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1923688
protein coding gene Chr17:50299285-50497702 (-)
129S1/SvImJ MGP_129S1SvImJ_G0023880
protein coding gene Chr17:51388296-51589327 (-)
A/J MGP_AJ_G0023840
protein coding gene Chr17:49994654-50195809 (-)
AKR/J MGP_AKRJ_G0023808
protein coding gene Chr17:50543728-50756970 (-)
BALB/cJ MGP_BALBcJ_G0023842
protein coding gene Chr17:49913674-50109717 (-)
C3H/HeJ MGP_C3HHeJ_G0023605
protein coding gene Chr17:51240990-51444218 (-)
C57BL/6NJ MGP_C57BL6NJ_G0024285
protein coding gene Chr17:53486804-53680541 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0021734
protein coding gene Chr17:46714386-46913739 (-)
CAST/EiJ MGP_CASTEiJ_G0023087
protein coding gene Chr17:51466843-51674306 (-)
CBA/J MGP_CBAJ_G0023581
protein coding gene Chr17:55471609-55688236 (-)
DBA/2J MGP_DBA2J_G0023710
protein coding gene Chr17:48759512-48956162 (-)
FVB/NJ MGP_FVBNJ_G0023676
protein coding gene Chr17:48450235-48646970 (-)
LP/J MGP_LPJ_G0023790
protein coding gene Chr17:52096312-52302286 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0023704
protein coding gene Chr17:54826085-55030980 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0024331
protein coding gene Chr17:50871361-51071213 (-)
PWK/PhJ MGP_PWKPhJ_G0022832
protein coding gene Chr17:48207532-48406380 (-)
SPRET/EiJ MGP_SPRETEiJ_G0022646
protein coding gene Chr17:47800249-48002895 (-)
WSB/EiJ MGP_WSBEiJ_G0023151
protein coding gene Chr17:51472774-51683337 (-)



Homology
more
  • Human Ortholog
    RFTN1, raftlin, lipid raft linker 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    RFTN1, raftlin, lipid raft linker 1
  • Synonyms
    MIG2, PIB10, PIG9, RAFTLIN
  • Links
    NCBI Gene ID: 23180
    neXtProt AC: NX_Q14699
    UniProt: Q14699

  • Chr Location
    3p24.3; chr3:16313574-16514026 (-)  GRCh38

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    16 phenotypes from 2 alleles in 2 genetic backgrounds
    7 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for null mutations have defects in T cell activation, T cell help to B cells, and Th17 differentation.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 76438 NCBI Gene Model | MGI Sequence Detail 197239 C57BL/6J ±  kb
    transcript NM_181397 RefSeq | MGI Sequence Detail 2802 C57BL/6  
    polypeptide Q6A0D4 UniProt | EBI | MGI Sequence Detail 554 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 41
      cDNA 41

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:2146943
    References
    more
    • Summaries
      All 31
      Developmental Gene Expression 1
      Gene Ontology 6
      Phenotypes 7
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:345458 Singh AK, et al., RORgammat-Raftlin1 complex regulates the pathogenicity of Th17 cells and colonic inflammation. Nat Commun. 2023 Aug 17;14(1):4972

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    last database update
    06/12/2024
    MGI 6.13
    The Jackson Laboratory