Zmym2 MGI Mouse Gene Detail - MGI:1923257

Symbol

Zmym2
Name

zinc finger, MYM-type 2
Synonyms

FIM, MGC:51607, MYM, RAMP, SCLL, Zfp198

Feature Type

protein coding gene
IDs

MGI:1923257
NCBI Gene: 76007
Alliance

genome feature page
Transcription Start Sites

7 TSS

Sequence Map

Chr14:57123986-57199815 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 14, 28.99 cM, cytoband C2
Mapping Data

3 experiments

SNPs within 2kb

1414 from dbSNP Build 142
Strain Annotations

19

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1923257	protein coding gene	Chr14:57123986-57200158 (+)
129S1/SvImJ	ENSMUSG00200041593	protein coding gene	Chr14:45709070-45785126 (+)
A/J	ENSMUSG00195027390	protein coding gene	Chr14:45924295-46000361 (+)
AKR/J	ENSMUSG00220023656	protein coding gene	Chr14:45251081-45327142 (+)
BALB/cJ	ENSMUSG00180051468	protein coding gene	Chr14:45546338-45622419 (+)
C3H/HeJ	ENSMUSG00175049334	protein coding gene	Chr14:47251637-47327711 (+)
C57BL/6NJ	ENSMUSG00215047211	protein coding gene	Chr14:45443176-45519240 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0019343	protein coding gene	Chr14:48131848-48198606 (+)
CAST/EiJ	ENSTCUG00005047119	protein coding gene	Chr14:47224232-47300450 (+)
CBA/J	ENSMUSG00210043930	protein coding gene	Chr14:45914763-45990813 (+)
DBA/2J	ENSMUSG00185030430	protein coding gene	Chr14:51038591-51114706 (+)
FVB/NJ	ENSMUSG00205038162	protein coding gene	Chr14:45318375-45394448 (+)
JF1/MsJ	ENSUMUG00000035910	protein coding gene	Chr14:62205335-62281650 (+)
LP/J	ENSMUSG00230051988	protein coding gene	Chr14:63078101-63154160 (+)
NOD/ShiLtJ	ENSMUSG00190045193	protein coding gene	Chr14:45681058-45757109 (+)
NZO/HlLtJ	ENSMUSG00225044620	protein coding gene	Chr14:53371412-53447469 (+)
PWK/PhJ	ENSLUMG00010045747	protein coding gene	Chr14:45141006-45217050 (+)
SPRET/EiJ	ENSMSPG00010041636	protein coding gene	Chr14:48633847-48711463 (+)
WSB/EiJ	ENSIUOG00005037262	protein coding gene	Chr14:45099625-45175722 (+)

Human Ortholog

ZMYM2, zinc finger MYM-type containing 2

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

ZMYM2, zinc finger MYM-type containing 2
Synonyms

FIM, MYM, NECRC, RAMP, SCLL, ZNF198
Links

HGNC:12989

NCBI Gene ID: 7750

UniProt: Q9UBW7
Chr Location

13q12.11; chr13:19863840-20091829 (+) GRCh38

MGI Vertebrate Homology

Zmym2 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: ZMYM2
Gene Tree

Zmym2

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Phenotype Summary

66 phenotypes from 4 alleles in 4 genetic backgrounds
4 images
25 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

52
Chemically induced (ENU)

1
Chemically induced (other)

1
Endonuclease-mediated

9
Gene trapped

38
Targeted

2
Transposon induced

1
Genomic Mutations

1 involving Zmym2
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

80 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Homozygous inactivation of this gene results in decreased embryo size, embryonic growth retardation, and complete lethality during organogenesis. Mice homozygous for a knock-out allele exhibit embryo turning and branchial arch/pouch defects, an abnormally shaped head, heart and tail, incomplete cranial neural tube closure, abnormal yolk sac vasculature, and an expanded spongiotrophoblast layer. Mice heterozygous for a transposon induced mutation show genitourinary defects, increased anxiety and aggressive-like behaviors, and glucose metabolism disorders.

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All GO Annotations

15
GO References

6

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

683
Tissues

60
cDNA Data

22
Literature Summary

11

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

GEISHA ZMYM2

Xenbase zmym2

ZFIN zmym2

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All Sequences

70
RefSeq

14
UniProt

4
CCDS

CCDS49506.1, CCDS88674.1

Ensembl

ENSMUSG00000021945 (Evidence)
NCBI Gene

76007

			Length	Strain/Species	Flank
genomic	76007	NCBI Gene Model \| MGI Sequence Detail	75830	C57BL/6J	± kb
transcript	NM_001360643	RefSeq \| MGI Sequence Detail	6785	C57BL/6
polypeptide	Q9CU65	UniProt \| EBI \| MGI Sequence Detail	1376	Not Applicable

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UniProt

4 Sequences
Protein Ontology

PR:000017687 zinc finger MYM-type protein 2

(term hierarchy)
InterPro Domains

IPR057926 QRICH1-like domain

IPR011017 TRASH domain

IPR010507 Zinc finger, MYM-type

IPR051284 Zinc finger MYM-type/QRICH1

IPR021893 ZMYM2-like/QRICH1, C-terminal domain
GlyGen

Q9CU65 1 site

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All nucleic 25

cDNA 22

Primer pair 2

Other 1

Antibodies 1

Microarray probesets 4

Summaries

All 65

Developmental Gene Expression 11

Gene Ontology 6

Phenotypes 25
Earliest

J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
Latest

J:386951 Guertin TM, et al., Onset of embryonic and placental defects coincide in 19 of 22 novel mid-gestation lethal murine knockout lines. Development. 2026 May 15;153(10):dev205276

TSS for Zmym2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr125856	Chr14:57124029-57124059 (+)	58 bp
Tssr125857	Chr14:57141371-57141396 (+)	17,398 bp
Tssr125858	Chr14:57146006-57146011 (+)	22,023 bp
Tssr125859	Chr14:57157206-57157210 (+)	33,222 bp
Tssr125860	Chr14:57162371-57162375 (+)	38,387 bp
Tssr125861	Chr14:57166615-57166630 (+)	42,637 bp
Tssr125862	Chr14:57176015-57176020 (+)	52,032 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 09/08/2026 MGI 6.24