About   Help   FAQ
Ccdc146 Gene Detail
Summary
  • Symbol
    Ccdc146
  • Name
    coiled-coil domain containing 146
  • Synonyms
    4930528G09Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1922422
    NCBI Gene: 75172
  • Alliance
    gene page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:21497959-21629675 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 5, 9.83 cM, cytoband A3
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    667 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1922422
 protein coding gene Chr5:21496749-21629675 (-)
129S1/SvImJ MGP_129S1SvImJ_G0029315
 protein coding gene Chr5:18837359-18971386 (-)
A/J MGP_AJ_G0029280
 protein coding gene Chr5:18233561-18361531 (-)
AKR/J MGP_AKRJ_G0029231
 protein coding gene Chr5:18922407-19058970 (-)
BALB/cJ MGP_BALBcJ_G0029292
 protein coding gene Chr5:18671956-18799344 (-)
C3H/HeJ MGP_C3HHeJ_G0029011
 protein coding gene Chr5:18995316-19130080 (-)
C57BL/6NJ MGP_C57BL6NJ_G0029745
 protein coding gene Chr5:20230681-20376208 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0026984
 protein coding gene Chr5:16296524-16421361 (-)
CAST/EiJ MGP_CASTEiJ_G0028423
 protein coding gene Chr5:18305388-18443345 (-)
CBA/J MGP_CBAJ_G0028978
 protein coding gene Chr5:20440055-20582108 (-)
DBA/2J MGP_DBA2J_G0029130
 protein coding gene Chr5:18508768-18640935 (-)
FVB/NJ MGP_FVBNJ_G0029088
 protein coding gene Chr5:17925483-18054066 (-)
LP/J MGP_LPJ_G0029214
 protein coding gene Chr5:19247084-19384018 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0029116
 protein coding gene Chr5:21744585-21887282 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0029778
 protein coding gene Chr5:18588895-18720335 (-)
PWK/PhJ MGP_PWKPhJ_G0028146
 protein coding gene Chr5:17565008-17689817 (-)
SPRET/EiJ MGP_SPRETEiJ_G0027979
 protein coding gene Chr5:17943608-18072056 (-)
WSB/EiJ MGP_WSBEiJ_G0028503
 protein coding gene Chr5:18637637-18780645 (-)



Homology
more
  • Human Ortholog
    CCDC146, coiled-coil domain containing 146
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CCDC146, coiled-coil domain containing 146
  • Synonyms
    MBO2
  • Links
    NCBI Gene ID: 57639
    neXtProt AC: NX_Q8IYE0
    UniProt: Q8IYE0

  • Chr Location
    7q11.23; chr7:77122434-77329533 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with Ccdc146 mouse models

Human Disease Mouse Models
      
IDs
 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    15 phenotypes from 1 allele in 1 genetic background
    15 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    3
  • GO References
    2
Molecular Function

No experimental evidence to support Molecular Function annotation, following literature review. See J:73796.
Biological Process

No experimental evidence to support Biological Process annotation, following literature review. See J:73796.
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    706
  • cDNA Data
    3
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000064280 Ensembl Gene Model | MGI Sequence Detail 131717 C57BL/6J ±  kb
    transcript ENSMUST00000115245 Ensembl | MGI Sequence Detail 3389 Not Applicable  
    polypeptide ENSMUSP00000110900 Ensembl | MGI Sequence Detail 977 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      4 Sequences
    Molecular
    Reagents
    less
    • All nucleic 3
      cDNA 3

      Microarray probesets 2
    References
    more
    • Summaries
      All 31
      Diseases 2
      Gene Ontology 2
      Phenotypes 15
    • Earliest
      J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
    • Latest
      J:344445 Ma Y, et al., CCDC146 is required for sperm flagellum biogenesis and male fertility in mice. Cell Mol Life Sci. 2023 Dec 1;81(1):1
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
    Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
    Send questions and comments to User Support.     		last database update
    04/16/2024
    MGI 6.23     		The Jackson Laboratory