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Dnm1l Gene Detail
Summary
  • Symbol
    Dnm1l
  • Name
    dynamin 1-like
  • Synonyms
    6330417M19Rik, Dnmlp1, Drp1, python
  • Feature Type
    protein coding gene
  • IDs
    MGI:1921256
    NCBI Gene: 74006
  • Alliance
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr16:16130094-16176823 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
  • Genetic Map
    Chromosome 16, 10.12 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    839 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1921256
protein coding gene Chr16:16130092-16176863 (-)
129S1/SvImJ MGP_129S1SvImJ_G0022557
protein coding gene Chr16:13419017-13467437 (-)
A/J MGP_AJ_G0022518
protein coding gene Chr16:12718128-12765486 (-)
AKR/J MGP_AKRJ_G0022495
protein coding gene Chr16:13231033-13286980 (-)
BALB/cJ MGP_BALBcJ_G0022523
protein coding gene Chr16:12889139-12936531 (-)
C3H/HeJ MGP_C3HHeJ_G0022290
protein coding gene Chr16:13332192-13384192 (-)
C57BL/6NJ MGP_C57BL6NJ_G0022972
protein coding gene Chr16:13585054-13634730 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0020492
protein coding gene Chr16:12814698-12862402 (-)
CAST/EiJ MGP_CASTEiJ_G0021817
protein coding gene Chr16:13273976-13323573 (-)
CBA/J MGP_CBAJ_G0022259
protein coding gene Chr16:14219055-14267340 (-)
DBA/2J MGP_DBA2J_G0022391
protein coding gene Chr16:12665388-12712422 (-)
FVB/NJ MGP_FVBNJ_G0022366
protein coding gene Chr16:12701545-12750229 (-)
LP/J MGP_LPJ_G0022458
protein coding gene Chr16:13211677-13263397 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0022388
protein coding gene Chr16:13887961-13956435 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0022985
protein coding gene Chr16:13170019-13218572 (-)
PWK/PhJ MGP_PWKPhJ_G0021559
protein coding gene Chr16:12894839-12942355 (-)
SPRET/EiJ MGP_SPRETEiJ_G0021387
protein coding gene Chr16:13160128-13204121 (-)
WSB/EiJ MGP_WSBEiJ_G0021865
protein coding gene Chr16:13177153-13225696 (-)



Homology
more
  • Human Ortholog
    DNM1L, dynamin 1 like
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    DNM1L, dynamin 1 like
  • Synonyms
    DLP1, DRP1, DVLP, DYMPLE, EMPF, EMPF1, HDYNIV, OPA5
  • Links
    NCBI Gene ID: 10059
    neXtProt AC: NX_O00429
    UniProt: O00429

  • Chr Location
    12p11.21; chr12:32679200-32745650 (+)  GRCh38

Human Diseases
more
  • Diseases
    1 with Dnm1l mouse models; 2 with human DNM1L associations

Human Disease Mouse Models
      
IDs
View 1 model
      
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    80 phenotypes from 7 alleles in 10 genetic backgrounds
    6 images
    92 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit embryonic lethality at E11.5 with internal hemorrhage and small size. Mice heterozygous for an ENU induced allele have dilated cardiomyopathy and congestive heart failure, homozygous are embryonic lethal with posterior truncation at E11.5. Brain isoform-specific KO results in ectopic dendrite growth in the hippocampus and enhanced sensorimotor gating.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000022789 Ensembl Gene Model | MGI Sequence Detail 46730 C57BL/6J ±  kb
    transcript ENSMUST00000230980 Ensembl | MGI Sequence Detail 2151 Not Applicable  
    polypeptide ENSMUSP00000155155 Ensembl | MGI Sequence Detail 716 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 26
      cDNA 26

      Microarray probesets 9
    Other
    Accession IDs
    less
    MGI:1195987, MGI:2146435
    References
    more
    • Summaries
      All 225
      Developmental Gene Expression 17
      Diseases 1
      Gene Ontology 29
      Phenotypes 92
    • Earliest
      J:45166 Kamimoto T, et al., Dymple, a novel dynamin-like high molecular weight GTPase lacking a proline-rich carboxyl-terminal domain in mammalian cells. J Biol Chem. 1998 Jan 9;273(2):1044-51
    • Latest
      J:355498 Piao L, et al., Dynamin-related protein 1 is a critical regulator of mitochondrial calcium homeostasis during myocardial ischemia/reperfusion injury. FASEB J. 2024 Jan;38(1):e23379

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    last database update
    11/19/2024
    MGI 6.24
    The Jackson Laboratory