Dnm1l^Py
Chemically induced Allele Detail

Summary

• Symbol: Dnm1l^Py
• Name: dynamin 1-like; Python
• MGI ID: MGI:4818906
• Synonyms: Py
• Gene: Dnm1l Location: Chr16:16130094-16176823 bp, - strand Genetic Position: Chr16, 10.12 cM
• Alliance: Dnm1l^Py page

Dnm1l^Py/Dnm1l⁺ mice exhibit dilated cardiomyopathy

Show the 4 phenotype image(s) involving this allele.

Mutation origin

• Strain of Origin: BALB/cAnNCrl

Mutation description

• Allele Type: Chemically induced (ENU)
• Mutation: Single point mutation
• Mutation details: This ENU induced mutation has a G/C to T/A transversion in exon 11, which alters amino acid 452 from the cysteine into the phenylalanine (C452F). (J:161510)

Disease models

Expression

In Structures Affected by this Mutation:

14 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Dnm1l Mutation: 43 strains or lines available

References

• Original: J:161510 Ashrafian H, et al., A mutation in the mitochondrial fission gene Dnm1l leads to cardiomyopathy. PLoS Genet. 2010;6(6):e1001000
• All: 2 reference(s)