Heatr6 Gene Detail

Summary

• Symbol
  Heatr6
• Name
  HEAT repeat containing 6
• Synonyms
  2700008B19Rik

• Feature Type
  protein coding gene
• IDs
  MGI:1919790
  NCBI Gene: 217026
• Alliance
  gene page
• Transcription Start Sites
  2 TSS

Location &
Maps

• Sequence Map
  Chr11:83644522-83674580 bp, + strand

  From Ensembl annotation of GRCm39
  

• View this region in JBrowse
  
  

• Genome Browsers
  Ensembl | UCSC | NCBI

• Genetic Map
  Chromosome 11, 51.23 cM, cytoband B5
• Mapping Data
  3 experiments

Strain
Comparison

• SNPs within 2kb
  322 from dbSNP Build 142
• Strain Annotations
  18

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1919790	protein coding gene	Chr11:83644463-83674580 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0018861	protein coding gene	Chr11:85135421-85166925 (+)
A/J	MGP_AJ_G0018828	protein coding gene	Chr11:81879888-81914965 (+)
AKR/J	MGP_AKRJ_G0018798	protein coding gene	Chr11:84318229-84348616 (+)
BALB/cJ	MGP_BALBcJ_G0018801	protein coding gene	Chr11:82281311-82311161 (+)
C3H/HeJ	MGP_C3HHeJ_G0018615	protein coding gene	Chr11:84367359-84400915 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0019253	protein coding gene	Chr11:87708727-87741260 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0016886	protein coding gene	Chr11:78990710-79021358 (+)
CAST/EiJ	MGP_CASTEiJ_G0018170	protein coding gene	Chr11:84990292-85020023 (+)
CBA/J	MGP_CBAJ_G0018586	protein coding gene	Chr11:91481934-91517655 (+)
DBA/2J	MGP_DBA2J_G0018694	protein coding gene	Chr11:81480023-81510014 (+)
FVB/NJ	MGP_FVBNJ_G0018683	protein coding gene	Chr11:80951093-80981212 (+)
LP/J	MGP_LPJ_G0018764	protein coding gene	Chr11:85669483-85701851 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0018710	protein coding gene	Chr11:91646713-91682021 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0019293	protein coding gene	Chr11:84585984-84617714 (+)
PWK/PhJ	MGP_PWKPhJ_G0017939	protein coding gene	Chr11:82226259-82256717 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0017731	protein coding gene	Chr11:84129929-84160007 (+)
WSB/EiJ	MGP_WSBEiJ_G0018221	protein coding gene	Chr11:84439456-84470021 (+)

Homology

• Human Ortholog
  HEATR6, HEAT repeat containing 6

• Vertebrate Orthologs
  3

Vertebrate Orthology Source

Alliance of Genome Resources

• Human Ortholog
  HEATR6, HEAT repeat containing 6
  
• Synonyms
  ABC1
• Links
  HGNC:24076

  NCBI Gene ID: 63897

  neXtProt AC: NX_Q6AI08

  UniProt: Q6AI08

  
  
• Chr Location
  17q23.1; chr17:60041363-60078931 (-)  GRCh38.p7

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• Alliance of Genome Resources
  Heatr6 stringent orthology
  1 human;1 mouse;1 rat;1 zebrafish
  
• HCOP
  vertebrate homology predictions: HEATR6
• Gene Tree
  Heatr6
  

Mutations,
Alleles, and
Phenotypes

• Phenotype Summary
  13 phenotype references
  

• All Mutations and Alleles
  6
• Chemically induced (other)
  1
• Gene trapped
  3
• Targeted
  2
• Genomic Mutations
  2 involving Heatr6
• Incidental Mutations
  Mutagenetix , APF , CvDC
• Find Mice (IMSR)
  22 strains or lines available

Expression

• Assay Results
  706
• cDNA Data
  93

Tissue x Stage Matrix

• Other Mouse Links
  Allen Institute
  GEO
  Expression Atlas
• Other Vertebrate Links
  Xenbase heatr6

Interactions

• Heatr6 interacts with 223 markers (Mir7-1, Mir9-1, Mir9-2, ...) View All

Sequences &
Gene Models

• All Sequences
  53
• RefSeq
  6
• UniProt
  1
• CCDS
  CCDS36259.1

• Ensembl
  ENSMUSG00000000976 (Evidence)
• NCBI Gene
  217026

Representative Sequences			Length	Strain/Species
genomic	ENSMUSG00000000976	Ensembl Gene Model | MGI Sequence Detail	30059	C57BL/6J
transcript	ENSMUST00000001002	Ensembl | MGI Sequence Detail	5614	Not Applicable
polypeptide	ENSMUSP00000001002	Ensembl | MGI Sequence Detail	1184	Not Applicable

Protein
Information

• UniProt
  1 Sequence
• Protein Ontology
  PR:000008498 HEAT repeat-containing protein 6
  (term hierarchy)
• InterPro Domains
  IPR011989 Armadillo-like helical
  IPR016024 Armadillo-type fold
  IPR025283 Domain of unknown function DUF4042

Molecular
Reagents

• All nucleic 95

  cDNA 95

  
  

  Microarray probesets 8

Other
Accession IDs

MGI:2144604, MGI:3034229

References

• Summaries
  All 37

  Phenotypes 13
• Earliest
  J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
• Latest
  J:174216 Terzian T, et al., Rpl27a mutation in the sooty foot ataxia mouse phenocopies high p53 mouse models. J Pathol. 2011 Aug;224(4):540-52

TSS for Heatr6:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr103760	Chr11:83644515-83644548 (+)	10 bp
Tssr103761	Chr11:83662801-83662805 (+)	18,281 bp