1600014C10Rik MGI Mouse Gene Detail - MGI:1919494

Symbol

1600014C10Rik
Name

RIKEN cDNA 1600014C10 gene

Feature Type

protein coding gene
IDs

MGI:1919494
NCBI Gene: 72244
Alliance

gene page
Transcription Start Sites

9 TSS

Sequence Map

Chr7:37882642-37896992 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 7, 25.36 cM, cytoband B1
Mapping Data

3 experiments

SNPs within 2kb

387 from dbSNP Build 142
Strain Annotations

17

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1919494	protein coding gene	Chr7:37882642-37896992 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0032101	protein coding gene	Chr7:37741740-37755885 (+)
A/J	MGP_AJ_G0032081	protein coding gene	Chr7:36684862-36701446 (+)
AKR/J	MGP_AKRJ_G0032014	protein coding gene	Chr7:37594775-37732026 (+)
BALB/cJ	MGP_BALBcJ_G0032088	protein coding gene	Chr7:36989836-37003984 (+)
C3H/HeJ	MGP_C3HHeJ_G0031805	protein coding gene	Chr7:38482870-38497004 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0032565	protein coding gene	Chr7:39555876-39570240 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0029598	protein coding gene	Chr7:37390881-37405414 (+)
CAST/EiJ	MGP_CASTEiJ_G0031140	protein coding gene	Chr7:29749083-29763180 (+)
CBA/J	MGP_CBAJ_G0031773	protein coding gene	Chr7:40822396-40839473 (+)
DBA/2J	MGP_DBA2J_G0031925	protein coding gene	Chr7:36511811-36526090 (+)
FVB/NJ	no annotation
LP/J	MGP_LPJ_G0032002	protein coding gene	Chr7:38086357-38100519 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0031918	protein coding gene	Chr7:39662812-39733889 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0032580	protein coding gene	Chr7:37201291-37216498 (+)
PWK/PhJ	MGP_PWKPhJ_G0030862	protein coding gene	Chr7:29902862-29917167 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0030697	protein coding gene	Chr7:26755465-26769925 (+)
WSB/EiJ	MGP_WSBEiJ_G0031250	protein coding gene	Chr7:37729677-37743823 (+)

Human Ortholog

C19orf12, chromosome 19 open reading frame 12

Vertebrate Orthologs

6

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

C19orf12, chromosome 19 open reading frame 12
Synonyms

MPAN, NBIA3, NBIA4, SPG43
Links

HGNC:25443

NCBI Gene ID: 83636

neXtProt AC: NX_Q9NSK7

UniProt: Q9NSK7
Chr Location

19q12; chr19:29698886-29715789 (-) GRCh38

MGI Vertebrate Homology

1600014C10Rik stringent orthology
1 human;1 mouse;1 rat;4 zebrafish
HCOP

vertebrate homology predictions: C19orf12
Gene Tree

1600014C10Rik

Diseases

2 with human C19orf12 associations

				Human Disease	Mouse Models
				hereditary spastic paraplegia 43 IDs hereditary spastic paraplegia 43 DOID:0110795 ICD10CM:G11.4 OMIM:615043 ORDO:320370
				neurodegeneration with brain iron accumulation 4 IDs neurodegeneration with brain iron accumulation 4 DOID:0110738 ICD10CM:G23.0 OMIM:614298 ORDO:289560

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

5 phenotype references

All Mutations and Alleles

6
Endonuclease-mediated

1
Gene trapped

4
Targeted

1
Incidental Mutations

CvDC
Find Mice (IMSR)

8 strains or lines available

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All GO Annotations

16
GO References

4

Molecular Function

No experimental evidence to support Molecular Function annotation, following literature review. See J:73796.

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

706
cDNA Data

107
Literature Summary

1

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

ZFIN si:ch211-260e23.7, si:ch211-260e23.8, zgc:101715, zgc:112052

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All Sequences

54
RefSeq

4
UniProt

3

Ensembl

ENSMUSG00000054676 (Evidence)
NCBI Gene

72244

			Length	Strain/Species	Flank
genomic	72244	NCBI Gene Model \| MGI Sequence Detail	14351	C57BL/6J	± kb
transcript	NM_001085385	RefSeq \| MGI Sequence Detail	3357	C57BL/6
polypeptide	Q8WUR0	UniProt \| EBI \| MGI Sequence Detail	141	Not Applicable

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UniProt

3 Sequences
Protein Ontology

PR:000060108 protein C19orf12

(term hierarchy)
InterPro Domains

IPR033369 Protein C19orf12

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All nucleic 107

cDNA 107

Microarray probesets 5

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MGI:2141949

Summaries

All 32

Developmental Gene Expression 1

Gene Ontology 4

Phenotypes 5
Earliest

J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
Latest

J:267911 Timmermans S, et al., Overview of inactivating mutations in the protein-coding genome of the mouse reference strain C57BL/6J. JCI Insight. 2018 Jul 12;3(13)

TSS for 1600014C10Rik:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr65934	Chr7:37882213-37882247 (+)	-412 bp
Tssr65935	Chr7:37882610-37882624 (+)	-25 bp
Tssr65936	Chr7:37882649-37882703 (+)	34 bp
Tssr65937	Chr7:37883072-37883093 (+)	441 bp
Tssr65938	Chr7:37883175-37883182 (+)	537 bp
Tssr65939	Chr7:37883229-37883294 (+)	620 bp
Tssr65940	Chr7:37883301-37883310 (+)	664 bp
Tssr65941	Chr7:37885660-37885674 (+)	3,025 bp
Tssr65942	Chr7:37885679-37885687 (+)	3,041 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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