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Chit1 Gene Detail
Summary
  • Symbol
    Chit1
  • Name
    chitinase 1
  • Synonyms
    2300002L19Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1919134
    NCBI Gene: 71884
  • Alliance
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:134038980-134079278 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
  • Genetic Map
    Chromosome 1, 58.12 cM, cytoband E4
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1277 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1919134
protein coding gene Chr1:134038980-134079279 (+)
129S1/SvImJ MGP_129S1SvImJ_G0016498
protein coding gene Chr1:137757608-137793942 (+)
A/J MGP_AJ_G0016481
protein coding gene Chr1:132576978-132612168 (+)
AKR/J MGP_AKRJ_G0016446
protein coding gene Chr1:136533853-136568780 (+)
BALB/cJ MGP_BALBcJ_G0016441
protein coding gene Chr1:132909441-132945781 (+)
C3H/HeJ MGP_C3HHeJ_G0016267
protein coding gene Chr1:136630289-136667756 (+)
C57BL/6NJ MGP_C57BL6NJ_G0016902
protein coding gene Chr1:142783415-142819920 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0014613
protein coding gene Chr1:125719361-125755332 (+)
CAST/EiJ MGP_CASTEiJ_G0015847
protein coding gene Chr1:135675002-135718717 (+)
CBA/J MGP_CBAJ_G0016240
protein coding gene Chr1:147706969-147760079 (+)
DBA/2J MGP_DBA2J_G0016346
protein coding gene Chr1:131587410-131622911 (+)
FVB/NJ MGP_FVBNJ_G0016345
protein coding gene Chr1:130216246-130251028 (+)
LP/J MGP_LPJ_G0016417
protein coding gene Chr1:139029594-139066284 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0016370
protein coding gene Chr1:153429005-153466119 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0016938
protein coding gene Chr1:136253487-136295166 (+)
PWK/PhJ MGP_PWKPhJ_G0015633
protein coding gene Chr1:130604255-130642713 (+)
SPRET/EiJ MGP_SPRETEiJ_G0015420
protein coding gene Chr1:135224733-135263486 (+)
WSB/EiJ MGP_WSBEiJ_G0015910
protein coding gene Chr1:136280585-136326387 (+)



Homology
more
  • Human Ortholog
    CHIT1, chitinase 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CHIT1, chitinase 1
  • Synonyms
    CHI3, CHIT, CHITD
  • Links
    NCBI Gene ID: 1118
    neXtProt AC: NX_Q13231
    UniProt: Q13231

  • Chr Location
    1q32.1; chr1:203212827-203273641 (-)  GRCh38

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    1 phenotype from multigenic genotypes
    15 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit reduced pulmonary fibrosis induced by bleomycin or IL13 expression.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000026450 Ensembl Gene Model | MGI Sequence Detail 40299 C57BL/6J ±  kb
transcript ENSMUST00000159963 Ensembl | MGI Sequence Detail 1815 Not Applicable  
polypeptide ENSMUSP00000123979 Ensembl | MGI Sequence Detail 464 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 11
    cDNA 9
    Primer pair 2

    Microarray probesets 3
References
more
  • Summaries
    All 45
    Developmental Gene Expression 2
    Gene Ontology 6
    Phenotypes 15
  • Earliest
    J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
  • Latest
    J:339269 Sklepkiewicz P, et al., Inhibition of CHIT1 as a novel therapeutic approach in idiopathic pulmonary fibrosis. Eur J Pharmacol. 2022 Mar 15;919:174792

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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last database update
10/29/2024
MGI 6.24
The Jackson Laboratory