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Coasy Gene Detail
Summary
  • Symbol
    Coasy
  • Name
    Coenzyme A synthase
  • Synonyms
    1300003G02Rik, Dpck, Ppat, Ukr1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1918993
    NCBI Gene: 71743
  • Alliance
    gene page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:100973391-100977445 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 11, 64.17 cM, cytoband D
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    14 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1918993
 protein coding gene Chr11:100973391-100977445 (+)
129S1/SvImJ MGP_129S1SvImJ_G0019178
 protein coding gene Chr11:103892587-103897441 (+)
A/J MGP_AJ_G0019146
 protein coding gene Chr11:99539843-99543897 (+)
AKR/J MGP_AKRJ_G0019115
 protein coding gene Chr11:102636876-102640930 (+)
BALB/cJ MGP_BALBcJ_G0019120
 protein coding gene Chr11:100034326-100038405 (+)
C3H/HeJ MGP_C3HHeJ_G0018929
 protein coding gene Chr11:102806762-102810852 (+)
C57BL/6NJ MGP_C57BL6NJ_G0019569
 protein coding gene Chr11:107108252-107112560 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0017195
 protein coding gene Chr11:96957918-96961961 (+)
CAST/EiJ MGP_CASTEiJ_G0018483
 protein coding gene Chr11:103793256-103799169 (+)
CBA/J MGP_CBAJ_G0018898
 protein coding gene Chr11:111572344-111576397 (+)
DBA/2J MGP_DBA2J_G0019010
 protein coding gene Chr11:99074871-99078910 (+)
FVB/NJ MGP_FVBNJ_G0019000
 protein coding gene Chr11:98617582-98622255 (+)
LP/J MGP_LPJ_G0019079
 protein coding gene Chr11:104442156-104447300 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0019031
 protein coding gene Chr11:111140898-111144937 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0019607
 protein coding gene Chr11:102955168-102960472 (+)
PWK/PhJ MGP_PWKPhJ_G0018246
 protein coding gene Chr11:100125507-100129593 (+)
SPRET/EiJ MGP_SPRETEiJ_G0018038
 protein coding gene Chr11:102691521-102695584 (+)
WSB/EiJ MGP_WSBEiJ_G0018532
 protein coding gene Chr11:102954421-102958840 (+)



Homology
more
  • Human Ortholog
    COASY, Coenzyme A synthase
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    COASY, Coenzyme A synthase
  • Synonyms
    DPCK, NBIA6, NBP, PCH12, pOV-2, PPAT, UKR1
  • Links
    NCBI Gene ID: 80347
    neXtProt AC: NX_Q13057
    UniProt: Q13057

  • Chr Location
    17q21.2; chr17:42561467-42566277 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with Coasy mouse models; 3 with human COASY associations

Human Disease Mouse Models
      
IDs
 View 1 model
      
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    18 phenotypes from 2 alleles in 2 genetic backgrounds
    9 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a conditional allele activated in the brain exhibit growth retardation after 8 weeks, impaired righting response, positive geotaxis, decreased brain weight, dystonia, increased brain iron, calcium, and magnesium levels, and premature death around P13.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    19
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    814
  • Tissues
    108
  • cDNA Data
    10
  • Literature Summary
    2
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 71743 NCBI Gene Model | MGI Sequence Detail 4055 C57BL/6J ±  kb
    transcript NM_001305982 RefSeq | MGI Sequence Detail 2153 Not Specified  
    polypeptide Q9DBL7 UniProt | EBI | MGI Sequence Detail 563 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 10
      cDNA 10

      Microarray probesets 3
    References
    more
    • Summaries
      All 36
      Developmental Gene Expression 2
      Diseases 1
      Gene Ontology 8
      Phenotypes 9
    • Earliest
      J:56548 Zheng B, et al., Engineering a mouse balancer chromosome. Nat Genet. 1999 Aug;22(4):375-8
    • Latest
      J:299154 Di Meo I, et al., Neuronal Ablation of CoA Synthase Causes Motor Deficits, Iron Dyshomeostasis, and Mitochondrial Dysfunctions in a CoPAN Mouse Model. Int J Mol Sci. 2020 Dec 19;21(24):9707
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/16/2024
    MGI 6.23     		The Jackson Laboratory