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Targeted Allele Detail
Symbol: Coasytm1.1Vtr
Name: Coenzyme A synthase; targeted mutation 1.1, Valeria Tiranti
MGI ID: MGI:6491679
Synonyms: Coasyflox
Gene: Coasy  Location: Chr11:100973391-100977445 bp, + strand  Genetic Position: Chr11, 64.17 cM, cytoband D
Alliance: Coasytm1.1Vtr page
Germline Transmission:  Earliest citation of germline transmission: J:299154
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
Mutation detailsThe ETPG00282_Y_2_E03 IMPC vector inserted an FRT site, lacZ reporer gene, loxP site, neomycin resistance cassette, FRT site, and loxP site upstream of exon 2. An additional loxP site was inserted downstream of the coding sequence in exon 9. Flp-mediated recombination removed the reporter/selection cassette and left exons 2 through 9 floxed. (J:299154)
View phenotypes and curated references for all genotypes (concatenated display).
Disease models
In Structures Affected by this Mutation: 2 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Coasy Mutation:  8 strains or lines available
Original:  J:299154 Di Meo I, et al., Neuronal Ablation of CoA Synthase Causes Motor Deficits, Iron Dyshomeostasis, and Mitochondrial Dysfunctions in a CoPAN Mouse Model. Int J Mol Sci. 2020 Dec 19;21(24):9707
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
MGI 6.22
The Jackson Laboratory