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Ythdf1 Gene Detail
Summary
  • Symbol
    Ythdf1
  • Name
    YTH N6-methyladenosine RNA binding protein 1
  • Synonyms
    2210410K23Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1917431
    NCBI Gene: 228994
  • Alliance
    genome feature page
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:180546170-180562729 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 2, 103.50 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    365 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1917431
 protein coding gene Chr2:180546170-180562742 (-)
129S1/SvImJ ENSMUSG00200001497
 protein coding gene Chr2:176568979-176585733 (-)
A/J ENSMUSG00195001067
 protein coding gene Chr2:176805757-176822329 (-)
AKR/J ENSMUSG00220000047
 protein coding gene Chr2:174484397-174500970 (-)
BALB/cJ ENSMUSG00180000372
 protein coding gene Chr2:174608197-174624951 (-)
C3H/HeJ ENSMUSG00175004202
 protein coding gene Chr2:175766349-175782919 (-)
C57BL/6NJ ENSMUSG00215002468
 protein coding gene Chr2:174708010-174724583 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0024790
 protein coding gene Chr2:170445336-170461619 (-)
CAST/EiJ ENSTCUG00005000640
 protein coding gene Chr2:174060666-174077225 (-)
CBA/J ENSMUSG00210001250
 protein coding gene Chr2:175086787-175103541 (-)
DBA/2J ENSMUSG00185019428
 protein coding gene Chr2:176325792-176342362 (-)
FVB/NJ ENSMUSG00205002100
 protein coding gene Chr2:175138125-175154698 (-)
JF1/MsJ ENSUMUG00000017282
 protein coding gene Chr2:177511274-177527842 (-)
LP/J ENSMUSG00230021058
 protein coding gene Chr2:178219922-178236676 (-)
NOD/ShiLtJ ENSMUSG00190015499
 protein coding gene Chr2:174628370-174645124 (-)
NZO/HlLtJ ENSMUSG00225006792
 protein coding gene Chr2:186306305-186322874 (-)
PWK/PhJ ENSLUMG00010000310
 protein coding gene Chr2:174937359-174953934 (-)
SPRET/EiJ ENSMSPG00010003966
 protein coding gene Chr2:177411555-177427778 (-)
WSB/EiJ ENSIUOG00005000046
 protein coding gene Chr2:174651763-174668342 (-)



Homology
more
  • Human Ortholog
    YTHDF1, YTH N6-methyladenosine RNA binding protein F1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    YTHDF1, YTH N6-methyladenosine RNA binding protein F1
  • Synonyms
    C20orf21, DF1
  • Links
    NCBI Gene ID: 54915
    UniProt: Q9BYJ9

  • Chr Location
    20q13.33; chr20:63195429-63216139 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with human YTHDF1 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    13 phenotypes from 2 alleles in 2 genetic backgrounds
    7 phenotypes from multigenic genotypes
    27 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit learning and memory defects as well as impaired hippocampal synaptic transmission and long-term potentiation.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    48
  • GO References
    11
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    610
  • Tissues
    6
  • cDNA Data
    108
  • Literature Summary
    7
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 228994 NCBI Gene Model | MGI Sequence Detail 16560 C57BL/6J ±  kb
transcript NM_173761 RefSeq | MGI Sequence Detail 3199 C57BL/6  
polypeptide P59326 UniProt | EBI | MGI Sequence Detail 559 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 109
    cDNA 108
    Primer pair 1
    Antibodies 1

    Microarray probesets 4
References
more
  • Summaries
    All 69
    Developmental Gene Expression 7
    Gene Ontology 11
    Phenotypes 27
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:387426 Shi Z, et al., mRNA m(6)A modifications and the RNA-binding protein YTHDF1 affect translational control in both normal and pathological learning. Proc Natl Acad Sci U S A. 2026 Apr 21;123(16):e2518250123
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/15/2026
MGI 6.29 		The Jackson Laboratory