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Mlip Gene Detail
Summary
  • Symbol
    Mlip
  • Name
    muscular LMNA-interacting protein
  • Synonyms
    2310046A06Rik, cardiac ISL1-interacting protein, CIP
  • Feature Type
    protein coding gene
  • IDs
    MGI:1916892
    NCBI Gene: 69642
  • Alliance
    genome feature page
  • Transcription Start Sites
    19 TSS
Location &
Maps
more
  • Sequence Map
    Chr9:77009366-77260062 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 9, 42.67 cM, cytoband E1
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    6718 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1916892
 protein coding gene Chr9:77009363-77260251 (-)
129S1/SvImJ ENSMUSG00200018541
 protein coding gene Chr9:74119104-74394348 (-)
A/J ENSMUSG00195010369
 protein coding gene Chr9:73903214-74154088 (-)
AKR/J ENSMUSG00220014688
 protein coding gene Chr9:74038034-74287199 (-)
BALB/cJ ENSMUSG00180015844
 protein coding gene Chr9:74016736-74267600 (-)
C3H/HeJ ENSMUSG00175010854
 protein coding gene Chr9:74049258-74300100 (-)
C57BL/6NJ ENSMUSG00215009960
 protein coding gene Chr9:73968038-74214382 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0032453
 protein coding gene Chr9:74081911-74328467 (-)
CAST/EiJ ENSTCUG00005008679
 protein coding gene Chr9:73721336-73961813 (-)
CBA/J ENSMUSG00210013073
 protein coding gene Chr9:74102224-74353055 (-)
DBA/2J ENSMUSG00185006382
 protein coding gene Chr9:74137512-74388378 (-)
FVB/NJ ENSMUSG00205018526
 protein coding gene Chr9:74406677-74656804 (-)
JF1/MsJ ENSUMUG00000035793
 protein coding gene Chr9:74103550-74352948 (-)
LP/J ENSMUSG00230022146
 protein coding gene Chr9:74293755-74546052 (-)
NOD/ShiLtJ ENSMUSG00190033363
 protein coding gene Chr9:74239410-74490270 (-)
NZO/HlLtJ ENSMUSG00225024817
 protein coding gene Chr9:74434940-74685776 (-)
PWK/PhJ ENSLUMG00010015287
 protein coding gene Chr9:74045874-74288757 (-)
SPRET/EiJ ENSMSPG00010004002
 protein coding gene Chr9:75264515-75518505 (-)
WSB/EiJ ENSIUOG00005024690
 protein coding gene Chr9:73576035-73826023 (-)



Homology
more
  • Human Ortholog
    MLIP, muscular LMNA interacting protein
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    MLIP, muscular LMNA interacting protein
  • Synonyms
    C6orf142, CIP, MMCKR
  • Links
    NCBI Gene ID: 90523
    UniProt: Q5VWP3

  • Chr Location
    6p12.1; chr6:53929982-54266946 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with human MLIP associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    8 phenotypes from 1 allele in 1 genetic background
    5 phenotypes from multigenic genotypes
    14 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele display increased cardiac sensitivity to induced stress.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    17
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    598
  • Tissues
    1
  • cDNA Data
    12
  • Literature Summary
    2
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 69642 NCBI Gene Model | MGI Sequence Detail 250697 C57BL/6J ±  kb
    transcript NM_001368955 RefSeq | MGI Sequence Detail 3002 C57BL/6  
    polypeptide Q5FW52 UniProt | EBI | MGI Sequence Detail 967 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 14
      cDNA 12
      Primer pair 1
      Other 1

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:2143167
    References
    more
    • Summaries
      All 43
      Developmental Gene Expression 2
      Gene Ontology 7
      Phenotypes 14
    • Earliest
      J:12013 Russell LB, Definition of functional units in a small chromosomal segment of the mouse and its use in interpreting the nature of radiation-induced mutations. Mutat Res. 1971 Jan;11(1):107-23
    • Latest
      J:332534 Yan Y, et al., Cardiac ISL1-Interacting Protein, a Cardioprotective Factor, Inhibits the Transition From Cardiac Hypertrophy to Heart Failure. Front Cardiovasc Med. 2022;9:857049
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/15/2026
    MGI 6.29     		The Jackson Laboratory