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Mlip Gene Detail
Summary
  • Symbol
    Mlip
  • Name
    muscular LMNA-interacting protein
  • Synonyms
    2310046A06Rik, cardiac ISL1-interacting protein, CIP
  • Feature Type
    protein coding gene
  • IDs
    MGI:1916892
    NCBI Gene: 69642
  • Alliance
    gene page
  • Transcription Start Sites
    19 TSS
Location &
Maps
more
  • Sequence Map
    Chr9:77009366-77260062 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 9, 42.67 cM, cytoband E1
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1535 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1916892
 protein coding gene Chr9:77009363-77260251 (-)
129S1/SvImJ MGP_129S1SvImJ_G0035051
 protein coding gene Chr9:77517449-77781609 (-)
A/J MGP_AJ_G0035032
 protein coding gene Chr9:74805629-75063564 (-)
AKR/J MGP_AKRJ_G0034961
 protein coding gene Chr9:76584185-76839292 (-)
BALB/cJ MGP_BALBcJ_G0035024
 protein coding gene Chr9:74492933-74743732 (-)
C3H/HeJ MGP_C3HHeJ_G0034733
 protein coding gene Chr9:77086479-77349673 (-)
C57BL/6NJ MGP_C57BL6NJ_G0035542
 protein coding gene Chr9:79580493-79846967 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0032453
 protein coding gene Chr9:74081911-74328467 (-)
CAST/EiJ MGP_CASTEiJ_G0034055
 protein coding gene Chr9:77440847-77700974 (-)
CBA/J MGP_CBAJ_G0034705
 protein coding gene Chr9:82339592-82628480 (-)
DBA/2J MGP_DBA2J_G0034865
 protein coding gene Chr9:74470695-74721658 (-)
FVB/NJ MGP_FVBNJ_G0034807
 protein coding gene Chr9:73734353-73976109 (-)
LP/J MGP_LPJ_G0034946
 protein coding gene Chr9:77749386-78016115 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0034848
 protein coding gene Chr9:83533329-83829439 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0035565
 protein coding gene Chr9:76758038-77028907 (-)
PWK/PhJ MGP_PWKPhJ_G0033759
 protein coding gene Chr9:74726295-74976899 (-)
SPRET/EiJ MGP_SPRETEiJ_G0033592
 protein coding gene Chr9:77021612-77279330 (-)
WSB/EiJ MGP_WSBEiJ_G0034167
 protein coding gene Chr9:76678482-76937329 (-)



Homology
more
  • Human Ortholog
    MLIP, muscular LMNA interacting protein
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    MLIP, muscular LMNA interacting protein
  • Synonyms
    C6orf142, CIP, MMCKR
  • Links
    NCBI Gene ID: 90523
    neXtProt AC: NX_Q5VWP3
    UniProt: Q5VWP3

  • Chr Location
    6p12.1; chr6:53929982-54266280 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    8 phenotypes from 1 allele in 1 genetic background
    5 phenotypes from multigenic genotypes
    14 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele display increased cardiac sensitivity to induced stress.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    13
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    707
  • Tissues
    1
  • cDNA Data
    12
  • Literature Summary
    2
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 69642 NCBI Gene Model | MGI Sequence Detail 250697 C57BL/6J ±  kb
    transcript NM_001368955 RefSeq | MGI Sequence Detail 3002 C57BL/6  
    polypeptide Q5FW52 UniProt | EBI | MGI Sequence Detail 967 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 14
      cDNA 12
      Primer pair 1
      Other 1

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:2143167
    References
    more
    • Summaries
      All 40
      Developmental Gene Expression 2
      Gene Ontology 6
      Phenotypes 14
    • Earliest
      J:12013 Russell LB, Definition of functional units in a small chromosomal segment of the mouse and its use in interpreting the nature of radiation-induced mutations. Mutat Res. 1971 Jan;11(1):107-23
    • Latest
      J:332534 Yan Y, et al., Cardiac ISL1-Interacting Protein, a Cardioprotective Factor, Inhibits the Transition From Cardiac Hypertrophy to Heart Failure. Front Cardiovasc Med. 2022;9:857049
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/16/2024
    MGI 6.23     		The Jackson Laboratory