Automated description from the Alliance of Genome Resources (Release 8.3.0)
Enables lamin binding activity and transcription corepressor activity. Involved in negative regulation of cardiac muscle hypertrophy in response to stress. Acts upstream of or within negative regulation of cardiac muscle hypertrophy and negative regulation of transcription by RNA polymerase II. Located in PML body; nuclear envelope; and sarcolemma. Is expressed in frontal suture frontal osteogenic front. Human ortholog(s) of this gene implicated in myopathy with myalgia, increased serum creatine kinase, and with or without episodic rhabdomyolysis 1. Orthologous to human MLIP (muscular LMNA interacting protein).
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