Tnfsf13 MGI Mouse Gene Detail - MGI:1916833 - tumor necrosis factor (ligand) superfamily, member 13

Symbol

Tnfsf13
Name

tumor necrosis factor (ligand) superfamily, member 13
Synonyms

2310026N09Rik, APRIL, TALL2, TRDL1

Feature Type

protein coding gene
IDs

MGI:1916833
NCBI Gene: 69583
Alliance

gene page
Transcription Start Sites

14 TSS

Sequence Map

Chr11:69573672-69576610 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 11, 42.86 cM, cytoband B4
Mapping Data

2 experiments

SNPs within 2kb

35 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1916833	protein coding gene	Chr11:69573403-69576610 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0018549	protein coding gene	Chr11:70141858-70144796 (-)
A/J	MGP_AJ_G0018517	protein coding gene	Chr11:67499795-67502733 (-)
AKR/J	MGP_AKRJ_G0018486	protein coding gene	Chr11:69509539-69512477 (-)
BALB/cJ	MGP_BALBcJ_G0018489	protein coding gene	Chr11:67809221-67812159 (-)
C3H/HeJ	MGP_C3HHeJ_G0018302	protein coding gene	Chr11:69541324-69544262 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0018940	protein coding gene	Chr11:72262912-72265850 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0016585	protein coding gene	Chr11:64418614-64421572 (-)
CAST/EiJ	MGP_CASTEiJ_G0017857	protein coding gene	Chr11:69782625-69785563 (-)
CBA/J	MGP_CBAJ_G0018275	protein coding gene	Chr11:75499270-75502208 (-)
DBA/2J	MGP_DBA2J_G0018384	protein coding gene	Chr11:67082262-67085199 (-)
FVB/NJ	MGP_FVBNJ_G0018374	protein coding gene	Chr11:66725568-66728506 (-)
LP/J	MGP_LPJ_G0018454	protein coding gene	Chr11:70710421-70713359 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0018397	protein coding gene	Chr11:76089814-76092752 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0018982	protein coding gene	Chr11:69771165-69774103 (-)
PWK/PhJ	MGP_PWKPhJ_G0017631	protein coding gene	Chr11:67732142-67735079 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0017421	protein coding gene	Chr11:69591106-69594046 (-)
WSB/EiJ	MGP_WSBEiJ_G0017911	protein coding gene	Chr11:69443466-69446404 (-)

Human Ortholog

TNFSF13, TNF superfamily member 13

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

TNFSF13, TNF superfamily member 13
Synonyms

APRIL, CD256, TALL2, TALL-2, TNLG7B, TRDL-1, UNQ383/PRO715, ZTNF2
Links

HGNC:11928

NCBI Gene ID: 8741

neXtProt AC: NX_O75888

UniProt: O75888
Chr Location

17p13.1; chr17:7558282-7561608 (+) GRCh38

MGI Vertebrate Homology

Tnfsf13 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: TNFSF13
Gene Tree

Tnfsf13

Diseases

1 with human TNFSF13 associations

				Human Disease	Mouse Models
				B-lymphoblastic leukemia/lymphoma IDs B-lymphoblastic leukemia/lymphoma DOID:0080630 NCI:C8936 UMLS_CUI:C0862030

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

21 phenotypes from 3 alleles in 3 genetic backgrounds
32 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

7
Chemically induced (other)

1
Endonuclease-mediated

1
Targeted

5
Genomic Mutations

2 involving Tnfsf13
Incidental Mutations

APF
Find Mice (IMSR)

68 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Homozygous null mice are viable and fertile. No apparent defects of the immune system have been reported.

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All GO Annotations

17
GO References

8

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

781
Tissues

49
cDNA Data

8
Literature Summary

5

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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All Sequences

40
RefSeq

4
UniProt

4
CCDS

CCDS48827.1

Ensembl

ENSMUSG00000089669 (Evidence)
NCBI Gene

69583

			Length	Strain/Species	Flank
genomic	ENSMUSG00000089669	Ensembl Gene Model \| MGI Sequence Detail	2939	C57BL/6J	± kb
transcript	ENSMUST00000018896	Ensembl \| MGI Sequence Detail	1407	Not Applicable
polypeptide	ENSMUSP00000018896	Ensembl \| MGI Sequence Detail	240	Not Applicable

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UniProt

4 Sequences
Protein Ontology

PR:000001947 tumor necrosis factor ligand superfamily member 13

(term hierarchy)
PDB

1U5X, 1U5Y, 1U5Z, 1XU1, 1XU2, 3K48
InterPro Domains

IPR021184 Tumour necrosis factor, conserved site

IPR006052 Tumour necrosis factor domain

IPR008983 Tumour necrosis factor-like domain superfamily

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All nucleic 11

cDNA 9

Primer pair 1

Other 1

Microarray probesets 1

Summaries

All 70

Developmental Gene Expression 5

Gene Ontology 8

Phenotypes 32
Earliest

J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
Latest

J:326541 Cyagen Biosciences Inc., Cyagen Biosciences Website. 2022;

TSS for Tnfsf13:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr108794	Chr11:69578135-69578153 (-)	-1,534 bp
Tssr108793	Chr11:69578112-69578126 (-)	-1,509 bp
Tssr108792	Chr11:69577887-69577907 (-)	-1,287 bp
Tssr108791	Chr11:69577855-69577871 (-)	-1,253 bp
Tssr108790	Chr11:69577765-69577779 (-)	-1,162 bp
Tssr108789	Chr11:69577742-69577754 (-)	-1,138 bp
Tssr108788	Chr11:69577713-69577724 (-)	-1,109 bp
Tssr108787	Chr11:69577654-69577666 (-)	-1,050 bp
Tssr108786	Chr11:69577573-69577623 (-)	-988 bp
Tssr108785	Chr11:69577549-69577565 (-)	-947 bp
Tssr108784	Chr11:69576363-69576391 (-)	233 bp
Tssr108783	Chr11:69576346-69576362 (-)	256 bp
Tssr108782	Chr11:69576163-69576174 (-)	441 bp
Tssr108781	Chr11:69576101-69576161 (-)	479 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 04/16/2024 MGI 6.23