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Tmem70 Gene Detail
Summary
  • Symbol
    Tmem70
  • Name
    transmembrane protein 70
  • Synonyms
    1110020A09Rik, 2210416J16Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1915068
    NCBI Gene: 70397
  • Alliance
    genome feature page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:16735431-16748499 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 1, 5.10 cM, cytoband A3
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    514 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1915068
 protein coding gene Chr1:16735415-16748501 (+)
129S1/SvImJ ENSMUSG00200018552
 protein coding gene Chr1:14125529-14138613 (+)
A/J ENSMUSG00195027203
 protein coding gene Chr1:13914416-13934626 (+)
AKR/J ENSMUSG00220008245
 protein coding gene Chr1:13969135-13982203 (+)
BALB/cJ ENSMUSG00180023265
 protein coding gene Chr1:13980772-14000983 (+)
C3H/HeJ ENSMUSG00175000238
 protein coding gene Chr1:13906827-13927036 (+)
C57BL/6NJ ENSMUSG00215010470
 protein coding gene Chr1:13949211-13962279 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0013970
 protein coding gene Chr1:12604243-12617073 (+)
CAST/EiJ ENSTCUG00005020633
 protein coding gene Chr1:14246666-14260088 (+)
CBA/J ENSMUSG00210002609
 protein coding gene Chr1:13772562-13792771 (+)
DBA/2J ENSMUSG00185003836
 protein coding gene Chr1:14836837-14857046 (+)
FVB/NJ ENSMUSG00205015912
 protein coding gene Chr1:14008600-14028810 (+)
JF1/MsJ ENSUMUG00000016647
 protein coding gene Chr1:14108011-14120613 (+)
LP/J ENSMUSG00230017644
 protein coding gene Chr1:14826867-14839945 (+)
NOD/ShiLtJ ENSMUSG00190027481
 protein coding gene Chr1:13882113-13902322 (+)
NZO/HlLtJ ENSMUSG00225004503
 protein coding gene Chr1:18223261-18243683 (+)
PWK/PhJ ENSLUMG00010020866
 protein coding gene Chr1:13697637-13710807 (+)
SPRET/EiJ ENSMSPG00010026803
 protein coding gene Chr1:14524306-14536985 (+)
WSB/EiJ ENSIUOG00005011642
 protein coding gene Chr1:13856673-13869736 (+)



Homology
more
  • Human Ortholog
    TMEM70, transmembrane protein 70
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TMEM70, transmembrane protein 70
  • Synonyms
    MC5DN2
  • Links
    NCBI Gene ID: 54968
    UniProt: Q9BUB7

  • Chr Location
    8q21.11; chr8:73972437-73982783 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with human TMEM70 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    27 phenotypes from 3 alleles in 3 genetic backgrounds
    10 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit complete embryonic lethality during organogenesis associated with severe growth delay, impaired biosynthesis and assembly of ATP synthase, decreased ATP production, oxidative stress, delayed heart development, and altered mitochondrial ultrastructure.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    30
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    835
  • Tissues
    26
  • cDNA Data
    82
  • Literature Summary
    2
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000025940 Ensembl Gene Model | MGI Sequence Detail 13069 C57BL/6J ±  kb
    transcript ENSMUST00000177501 Ensembl | MGI Sequence Detail 1636 Not Applicable  
    polypeptide ENSMUSP00000135483 Ensembl | MGI Sequence Detail 254 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 83
      cDNA 82
      Primer pair 1

      Microarray probesets 2
    Other
    Accession IDs
    less
    MGI:1917647
    References
    more
    • Summaries
      All 36
      Developmental Gene Expression 2
      Gene Ontology 8
      Phenotypes 10
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/01/2026
    MGI 6.24     		The Jackson Laboratory