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Daam1 Gene Detail
Summary
  • Symbol
    Daam1
  • Name
    dishevelled associated activator of morphogenesis 1
  • Synonyms
    1700066F09Rik, 2310028E21Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1914596
    NCBI Gene: 208846
  • Alliance
    gene page
  • Transcription Start Sites
    9 TSS
Location &
Maps
more
  • Sequence Map
    Chr12:71877852-72039107 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 12, 30.06 cM, cytoband C3
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1682 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1914596
 protein coding gene Chr12:71877724-72039150 (+)
129S1/SvImJ MGP_129S1SvImJ_G0019819
 protein coding gene Chr12:71638725-71801867 (+)
A/J MGP_AJ_G0019777
 protein coding gene Chr12:68972287-69129866 (+)
AKR/J MGP_AKRJ_G0019753
 protein coding gene Chr12:71040770-71203530 (+)
BALB/cJ MGP_BALBcJ_G0019757
 protein coding gene Chr12:69439451-69596824 (+)
C3H/HeJ MGP_C3HHeJ_G0019562
 protein coding gene Chr12:71505458-71663715 (+)
C57BL/6NJ MGP_C57BL6NJ_G0020209
 protein coding gene Chr12:73905052-74068523 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0017829
 protein coding gene Chr12:66452400-66609863 (+)
CAST/EiJ MGP_CASTEiJ_G0019114
 protein coding gene Chr12:66251822-66411583 (+)
CBA/J MGP_CBAJ_G0019532
 protein coding gene Chr12:76651429-76817297 (+)
DBA/2J MGP_DBA2J_G0019648
 protein coding gene Chr12:68875014-69035613 (+)
FVB/NJ MGP_FVBNJ_G0019635
 protein coding gene Chr12:67746477-67906754 (+)
LP/J MGP_LPJ_G0019720
 protein coding gene Chr12:71643606-71802951 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0019674
 protein coding gene Chr12:79851311-80013363 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0020244
 protein coding gene Chr12:70527261-70695163 (+)
PWK/PhJ MGP_PWKPhJ_G0018879
 protein coding gene Chr12:63169482-63369215 (+)
SPRET/EiJ MGP_SPRETEiJ_G0018674
 protein coding gene Chr12:64928754-65103151 (+)
WSB/EiJ MGP_WSBEiJ_G0019165
 protein coding gene Chr12:71144091-71305517 (+)



Homology
more
  • Human Ortholog
    DAAM1, dishevelled associated activator of morphogenesis 1
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    DAAM1, dishevelled associated activator of morphogenesis 1
  • Links
    NCBI Gene ID: 23002
    neXtProt AC: NX_Q9Y4D1
    UniProt: Q9Y4D1

  • Chr Location
    14q23.1; chr14:59188646-59371405 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with Daam1 mouse models

Human Disease Mouse Models
      
IDs
 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    30 phenotypes from 3 alleles in 4 genetic backgrounds
    22 phenotypes from multigenic genotypes
    22 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for a gene trap allele show reduced fetal size, partial embryonic and neonatal lethality, altered cytoskeletal structure, cardiac defects including ventricular noncompaction, double outlet right ventricles and ventricular septal defects, and impaired cell adhesion and wound healing.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    19
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    985
  • Tissues
    234
  • cDNA Data
    20
  • Literature Summary
    23
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000034574 Ensembl Gene Model | MGI Sequence Detail 161256 C57BL/6J ±  kb
    transcript ENSMUST00000085299 Ensembl | MGI Sequence Detail 5879 Not Applicable  
    polypeptide ENSMUSP00000082406 Ensembl | MGI Sequence Detail 1077 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 26
      cDNA 20
      Primer pair 6

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGI:1916850, MGI:2144851
    References
    more
    • Summaries
      All 74
      Developmental Gene Expression 23
      Diseases 1
      Gene Ontology 8
      Phenotypes 22
    • Earliest
      J:93290 Araki K, et al., Exchangeable gene trap using the Cre/mutated lox system. Cell Mol Biol (Noisy-Le-Grand). 1999 Jul;45(5):737-50
    • Latest
      J:343155 Colozza G, et al., Intestinal Paneth cell differentiation relies on asymmetric regulation of Wnt signaling by Daam1/2. Sci Adv. 2023 Nov 24;9(47):eadh9673
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/09/2024
    MGI 6.23     		The Jackson Laboratory