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Paics Gene Detail
Summary
  • Symbol
    Paics
  • Name
    phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoribosylaminoimidazole, succinocarboxamide synthetase
  • Synonyms
    2610511I09Rik, ADE2H1, AIRC, PAIS
  • Feature Type
    protein coding gene
  • IDs
    MGI:1914304
    NCBI Gene: 67054
  • Alliance
    genome feature page
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:77099154-77115356 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 5, 41.45 cM, cytoband E1
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    521 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1914304
 protein coding gene Chr5:77099149-77115356 (+)
129S1/SvImJ ENSMUSG00200000680
 protein coding gene Chr5:72789537-72805741 (+)
A/J ENSMUSG00195010220
 protein coding gene Chr5:72096144-72112356 (+)
AKR/J ENSMUSG00220014825
 protein coding gene Chr5:72207926-72224137 (+)
BALB/cJ ENSMUSG00180000042
 protein coding gene Chr5:71861335-71877539 (+)
C3H/HeJ ENSMUSG00175004138
 protein coding gene Chr5:73897218-73913428 (+)
C57BL/6NJ ENSMUSG00215000432
 protein coding gene Chr5:72675900-72692105 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0027322
 protein coding gene Chr5:69845979-69861896 (+)
CAST/EiJ ENSTCUG00005013193
 protein coding gene Chr5:71648581-71665056 (+)
CBA/J ENSMUSG00210000427
 protein coding gene Chr5:72835164-72851375 (+)
DBA/2J ENSMUSG00185015753
 protein coding gene Chr5:74665107-74681318 (+)
FVB/NJ ENSMUSG00205020931
 protein coding gene Chr5:71623422-71639635 (+)
JF1/MsJ ENSUMUG00000005885
 protein coding gene Chr5:79156710-79172916 (+)
LP/J ENSMUSG00230019904
 protein coding gene Chr5:79363493-79379696 (+)
NOD/ShiLtJ ENSMUSG00190007636
 protein coding gene Chr5:71786510-71802720 (+)
NZO/HlLtJ ENSMUSG00225033889
 protein coding gene Chr5:84410486-84426688 (+)
PWK/PhJ ENSLUMG00010007490
 protein coding gene Chr5:71730087-71746318 (+)
SPRET/EiJ no annotation
WSB/EiJ ENSIUOG00005017888
 protein coding gene Chr5:74632142-74648354 (+)



Homology
more
  • Human Ortholog
    PAICS, phosphoribosylaminoimidazole carboxylase and phosphoribosylaminoimidazolesuccinocarboxamide synthase
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PAICS, phosphoribosylaminoimidazole carboxylase and phosphoribosylaminoimidazolesuccinocarboxamide synthase
  • Synonyms
    ADE2, ADE2H1, AIRC, PAICSD, PAIS
  • Links
    NCBI Gene ID: 10606
    UniProt: P22234

  • Chr Location
    4q12; chr4:56410507-56464578 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with human PAICS associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    2 phenotypes from 1 allele in 1 genetic background
    14 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    62
  • Chemically induced (other)
    2
  • Endonuclease-mediated
    3
  • Gene trapped
    56
  • Spontaneous
    1
  • Genomic Mutations
    3 involving Paics
  • Incidental Mutations
    APF
  • Find Mice (IMSR)
    35 strains or lines available
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    32
  • GO References
    9
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    815
  • Tissues
    136
  • cDNA Data
    13
  • Literature Summary
    7
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000029247 Ensembl Gene Model | MGI Sequence Detail 16203 C57BL/6J ±  kb
transcript ENSMUST00000031160 Ensembl | MGI Sequence Detail 2482 Not Applicable  
polypeptide ENSMUSP00000031160 Ensembl | MGI Sequence Detail 425 Not Applicable  
For the selected sequence
Protein
Information
less
  • UniProt
    3 Sequences
  • Protein Ontology
    PR:000012235 bifunctional phosphoribosylaminoimidazole carboxylase/phosphoribosylaminoimidazole succinocarboxamide synthetase
    (term hierarchy)
  • EC
    4.1.1.21, 6.3.2.6
  • InterPro Domains
    IPR033626 Class II PurE
    IPR000031 PurE domain
    IPR028923 SAICAR synthetase/ADE2, N-terminal
    IPR018236 SAICAR synthetase, conserved site
  • GlyGen
    Q9DCL9 2 sites, 1 N-linked glycan (1 site), 1 O-linked glycan (1 site)
Molecular
Reagents
less
  • All nucleic 17
    cDNA 16
    Primer pair 1

    Microarray probesets 4
References
more
  • Summaries
    All 55
    Developmental Gene Expression 7
    Gene Ontology 9
    Phenotypes 14
  • Earliest
    J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
  • Latest
    J:385442 Li M, et al., SAICAR Drives T Regulatory Cell Differentiation and FOXP3 Maintenance to Promote Immunotherapy Resistance. Cancer Res. 2026 May 4;86(9):2218-2236
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/15/2026
MGI 6.29 		The Jackson Laboratory